Abstract:
:The double-stranded RNA dependent protein kinase (PKR) is a negative regulator of cell proliferation and thus itself a target for modulation. We show that a cell-permeable peptide (PRI), containing a conserved double-stranded RNA binding motif found in PKR, inhibits activation of the kinase and activity to phosphorylate its substrate. Further, the PRI-peptide localizes to the cytoplasm of murine embryonic fibroblasts and ablates cellular PKR activation. The PRI-peptide enhances cell proliferation compared to treatment with a variant control peptide, resulting in cultures with increased cell density. We conclude that peptides that interfere with PKR may be useful tools for regulating cell proliferation.
journal_name
Peptidesjournal_title
Peptidesauthors
Nekhai S,Bottaro DP,Woldehawariat G,Spellerberg A,Petryshyn Rdoi
10.1016/s0196-9781(00)00297-7subject
Has Abstractpub_date
2000-10-01 00:00:00pages
1449-56issue
10eissn
0196-9781issn
1873-5169pii
S0196-9781(00)00297-7journal_volume
21pub_type
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