Evaluation of Enhanced Lipid Oxidation and Compensatory Suppression using Natriuretic Peptide in Patients with Cardiovascular Diseases.

abstract：:A novel protease inhibitor, designated mungoin, with both antifungal and antibacterial activities, and exhibiting a molecular mass of 10kDa in SDS-polyacrylamide gel electrophoresis, was isolated from mung bean (Phaseolus mungo) seeds. The isolation procedure involved a combination of extraction, ammonium sulfate prec...

journal_title：Peptides

authors： Wang S,Lin J,Ye M,Ng TB,Rao P,Ye X

更新日期：2006-12-01 00:00:00

abstract：:Endothelin-1 may contribute to bronchial smooth muscle constriction and airway remodelling in asthma, where bronchial epithelial cells represent an important source of this peptide. We report here that asthmatic bronchial epithelial cells exposed to allergens in vitro induce the differentiation of airway fibroblasts i...

journal_title：Peptides

authors： Sun G,Stacey MA,Bellini A,Marini M,Mattoli S

更新日期：1997-01-01 00:00:00

abstract：:Investigators studying the primary culprit responsible for Alzheimer disease have, for the past two decades, primarily focused on amyloid-beta (Abeta). Here, we put Abeta on trial and review evidence amassed by the prosecution that implicate Abeta and also consider arguments and evidence gathered by the defense team w...

journal_title：Peptides

authors： Rottkamp CA,Atwood CS,Joseph JA,Nunomura A,Perry G,Smith MA

更新日期：2002-07-01 00:00:00

abstract：:Solubilization of rat synaptic membranes by Triton X-100 followed by DEAE-cellulose chromatography allowed the separation of a phosphoramidon-sensitive endopeptidase that cleaved CCK-8. This enzymatic activity revealed similar if not identical to "enkephalinase A." A major cleavage point, at the Trp30-Met31 bond, and ...

journal_title：Peptides

authors： Deschodt-Lanckman M,Koulischer D,Przedborski S,Lauwereys M

更新日期：1984-05-01 00:00:00

abstract：:Neuropeptide FF (NPFF) has been shown to act as an endogenous anti-analgesic peptide. In this paper, several peptide analogs of the selective ligand dNP(NMe)AFLFQPQRF-NH(2) modified in the putative address segment, were designed to be selective NPFF(2) receptor probes, synthesized and assayed. One peptide dA(NMe)AAFLF...

journal_title：Peptides

authors： Mazarguil H,Mollereau C,Czaplicki G,Zajac JM

更新日期：2012-09-01 00:00:00

abstract：:For clinical use, it is essential to develop potent endomorphin (EM) analogs with reduced antinociceptive tolerance. In the present study, the antinociceptive activities and tolerance development of four potent EM-1 analogs with C-terminal oligoarginine-conjugation was evaluated and compared in the radiant heat paw wi...

journal_title：Peptides

authors： Yuan BY,Liu WZ,Wang XF,Zhang YZ,Yang DJ,Wang CL

更新日期：2018-08-01 00:00:00

abstract：:The functions of leptin receptors (LRs) are cell-type specific. At the blood-brain barrier, LRs mediate leptin transport that is essential for its CNS actions, and both endothelial and astrocytic LRs may be involved. To test this, we generated endothelia specific LR knockout (ELKO) and astrocyte specific LR knockout (...

journal_title：Peptides

authors： Hsuchou H,Kastin AJ,Tu H,Markadakis EN,Stone KP,Wang Y,Heymsfield SB,Chua SS Jr,Obici S,Magrisso IJ,Pan W

更新日期：2011-07-01 00:00:00

abstract：:Neuronostatin is a 13-amino acid amidated peptide widely distributed in various organs including gastrointestinal tract. However, the effect of neuronostatin on gastrointestinal motility has not been well characterized. In the present work, effects of central administration of neuronostatin on gastric emptying and gas...

journal_title：Peptides

authors： Su SF,Yang AM,Yang SB,Wang NB,Lu SS,Wang HH,Chen Q

更新日期：2012-05-01 00:00:00

abstract：:Effects of pentobarbital, chlordiazepoxide and ethanol were studied alone and in combination with thyrotropin-releasing hormone (TRH), IM, on punished behavior. Key-peck responses of pigeons were maintained by food presentation under a fixed-interval 3-min schedule in which every 30th response produced shock. Moderate...

journal_title：Peptides

authors： Witkin JM,Sickle J,Barrett JE

更新日期：1984-07-01 00:00:00

abstract：:Hymenochirin-1B (IKLSPETKDN(10)LKKVLKGAIK(20)GAIAVAKMV.NH2) is a cationic, amphipathic, α-helical, host-defense peptide, first isolated from skin secretions of the Congo clawed frog Hymenochirus boettgeri (Pipidae). Structure-activity relationships were investigated by synthesizing analogs in which the Pro(5), Glu(6) ...

journal_title：Peptides

authors： Mechkarska M,Prajeep M,Radosavljevic GD,Jovanovic IP,Al Baloushi A,Sonnevend A,Lukic ML,Conlon JM

更新日期：2013-12-01 00:00:00

abstract：:We employed a proteomic approach to search for peptides that have a physiological role in labor. Cervicovaginal secretions were collected at term from women in labor and women at term not in labor. Samples were spotted onto weak cation exchange chips (WCX-2) and analyzed using Surface-Enhanced Laser Desorption Ionizat...

journal_title：Peptides

authors： Brown AG,Leite RS,Engler AJ,Discher DE,Strauss JF 3rd

更新日期：2006-07-01 00:00:00

abstract：:Opiate alkaloids and opioid peptides have been shown to suppress plasma LH and FSH levels via a naloxone sensitive mechanism in several species including man. Three subtypes of opiate receptors have been characterized: mu, delta and kappa. The present study was designed to investigate their role in gonadotropin releas...

journal_title：Peptides

authors： Pfeiffer DG,Pfeiffer A,Shimohigashi Y,Merriam GR,Loriaux DL

更新日期：1983-09-01 00:00:00

abstract：:Effects of rat and human calcitonin gene-related peptide (r alpha CGRP and h beta CGRP, respectively) upon uterine contractile force were investigated using uterine horns from nonpregnant rats, r alpha CGRP and h beta CGRP were equipotent (pD2 = 8.85-9.09) in inhibiting spontaneous and electrically evoked uterine cont...

journal_title：Peptides

authors： Pennefather JN,Reynoldson NA,Handberg GM

更新日期：1990-09-01 00:00:00

abstract：:NPFF receptors are expressed in several brain regions directly or indirectly involved in cognition and behavior. However, the cognitive effects of the NPFF system have been poorly studied. Therefore, the aim of our study was to analyze the effects of i.c.v. injections of 1 DMe, a stable agonist of NPFF receptors, on b...

journal_title：Peptides

authors： Betourne A,Marty V,Ceccom J,Halley H,Lassalle JM,Zajac JM,Frances B,Mouledous L

更新日期：2010-02-01 00:00:00

abstract：:Activation of natriuretic peptide receptor-A (NPRA) produces the second messenger cGMP, which plays a pivotal role in maintaining blood pressure and cardiovascular homeostasis. In the present study, we have examined the role of trans-acting factor Ets-1 in transcriptional regulation of Npr1 gene (coding for NPRA). Usi...

journal_title：Peptides

authors： Kumar P,Arise KK,Pandey KN

更新日期：2006-07-01 00:00:00

abstract：:Two novel peptides, neuromedin U-8 and U-25, eliciting a potent uterus stimulating activity, have been purified and identified in porcine spinal cord. Sequence analyses and syntheses revealed that neuromedin U-8 is a novel octapeptide with a C-terminal amide structure, while U-25 contains the U-8 sequence at its C-ter...

journal_title：Peptides

authors： Minamino N,Sudoh T,Kangawa K,Matsuo H

更新日期：1985-01-01 00:00:00

abstract：:Antibodies directed against amyloid beta protein (AssP) have been suggested to be effective in the treatment of Alzheimer's disease (AD). Here, we used in vivo and in vitro models to test some of the mechanisms by which antibodies may produce their effects. We found that the blood-to-brain uptake of murine AssP1-42 wa...

journal_title：Peptides

authors： Banks WA,Pagliari P,Nakaoke R,Morley JE

更新日期：2005-02-01 00:00:00

abstract：:The effect of synthetic human calcitonin gene-related peptide (hCGRP) on the isolated and electrically driven left atria of rats were investigated. The peptide at concentrations of 3 X 10(-9)-3 X 10(-7) M produced positive inotropic effects on the left atria in a dose-dependent manner. Verapamil (10(-5) M) and adenosi...

journal_title：Peptides

authors： Satoh M,Oku R,Maeda A,Fujii N,Otaka A,Funakoshi S,Yajima H,Takagi H

更新日期：1986-07-01 00:00:00

abstract：:Binding studies have shown that [125I]NKA is a selective ligand of tachykinin septide-sensitive binding sites from membranes of the rat submaxillary gland. Indeed, this ligand bound with high affinity to a single population of sites. In addition, competition studies indicated that natural tachykinins and tachykinin-re...

journal_title：Peptides

authors： Beaujouan JC,Saffroy M,Torrens Y,Sagan S,Glowinski J

更新日期：1999-11-01 00:00:00

abstract：:The roles of thyrotropin releasing hormone (TRH) and oxytocin as central regulators of gastric motility were investigated. Picomolar (4 picomoles) quantities of TRH injected into the dorsal motor nucleus of the vagus (DMN) elicited a significant increase in gastric motility while the same quantity of oxytocin elicited...

journal_title：Peptides

authors： Rogers RC,Hermann GE

更新日期：1987-05-01 00:00:00

abstract：:An antifungal peptide with a molecular mass of 9412 and an N-terminal sequence exhibiting notable homology to those of lipid transfer proteins was isolated from seeds of the vegetable Brassica campestris. The purification protocol entailed ion exchange chromatography on Q-Sepharose, affinity chromatography on Affi-gel...

journal_title：Peptides

authors： Lin P,Xia L,Ng TB

更新日期：2007-08-01 00:00:00

abstract：:Insulin has been detected by ELISA in the vitreous of the normal and streptozotocin-diabetic rat at levels for both about 1% of those in serum. 131I-labeled insulin, administered to conscious rats via an indwelling cannula in the right atrium, was found to cross the blood-ocular barrier into the vitreous. Autoradiogra...

journal_title：Peptides

authors： Shires TK,Braddock KJ,Pulido JS

更新日期：1992-07-01 00:00:00

abstract：:Heat-stable enterotoxin b (STb) of Escherichia coli is a 48-amino acid basic, disulfide-bonded peptide that causes intestinal secretion in experimental animal models. Recent evidence suggests that the in vivo mechanism of STb action involves release of 5-hydroxytryptamine (5-HT) and production of prostaglandin E2 (PGE...

journal_title：Peptides

authors： Harville BA,Dreyfus LA

更新日期：1996-01-01 00:00:00

abstract：:Tardive dyskinesia, a clinical syndrome, is one of the major side effects of protracted treatment with neuroleptics in schizophrenic patients. Functional supersensitivity of striatal dopamine receptors is believed to contribute to the pathogenesis of schizophrenia and tardive dyskinesia. In a rodent model of neurolept...

journal_title：Peptides

authors： Rajakumar G,Naas F,Johnson RL,Chiu S,Yu KL,Mishra RK

更新日期：1987-09-01 00:00:00

abstract：:Heparin-binding EGF-like growth factor (HB-EGF), a member of the epidermal growth factor (EGF) family, can protect intestinal epithelial cells from various forms of injury in vitro and attenuate intestinal ischemia/reperfusion damage in vivo. With the goal of eventual clinical use of HB-EGF to protect the intestines f...

journal_title：Peptides

authors： Feng J,Mehta VB,El-Assal ON,Wu D,Besner GE

更新日期：2006-06-01 00:00:00

abstract：:Acute and chronic effects of gamma-butyrolactone-gamma-carbonyl-histidyl-prolinamide (DN-1417) were investigated on motor activity, dopamine (DA) metabolites and DA receptors in various brain regions of rats. The motor activity, as measured with Automex recorder, was enhanced after a single injection with DN-1417 (20 ...

journal_title：Peptides

authors： Nakahara T,Matsumoto T,Hirano M,Uchimura H,Yokoo H,Nakamura K,Ishibashi K,Hirano H

更新日期：1985-11-01 00:00:00

abstract：:We investigated the effect of synthetic antimicrobial decapeptide KSL-W (KKVVFWVKFK) on normal human gingival fibroblast growth, migration, collagen gel contraction, and α-smooth muscle actin protein expression. Results show that in addition to promoting fibroblast adhesion by increasing F-actin production, peptide KS...

journal_title：Peptides

authors： Park HJ,Salem M,Semlali A,Leung KP,Rouabhia M

更新日期：2017-07-01 00:00:00

abstract：:In recent years our knowledge of the nervous control of the cerebral circulation has increased. The use of denervations and retrograde tracing in combination with immunohistochemical techniques has demonstrated that cerebral vessels are supplied with sympathetic, parasympathetic, and sensory nerve fibers and possibly ...

journal_title：Peptides

authors： Gulbenkian S,Uddman R,Edvinsson L

更新日期：2001-06-01 00:00:00

abstract：:Orexin is one of the orexigenic neuropeptides in the hypothalamus. Orexin neurons in the lateral hypothalamus (LH) project into the cerebral cortex and hippocampus in which the receptors are distributed in high concentrations. Therefore, to elucidate the actions of orexin in the cerebral cortex, we examined its effect...

journal_title：Peptides

authors： Yamada N,Katsuura G,Tatsuno I,Asaki T,Kawahara S,Ebihara K,Saito Y,Nakao K

更新日期：2008-09-01 00:00:00

abstract：:Obestatin is purported to be a peptide hormone encoded in preproghrelin. We studied the metabolic effects of continuous infusion of obestatin via subcutaneously implanted osmotic mini-pumps. Administration of up to 500nmol/kg body weight/day obestatin did not change 24h cumulative food intake or body weight in rats. S...

journal_title：Peptides

authors： Unniappan S,Speck M,Kieffer TJ

更新日期：2008-08-01 00:00:00