Abstract:
:The roles of thyrotropin releasing hormone (TRH) and oxytocin as central regulators of gastric motility were investigated. Picomolar (4 picomoles) quantities of TRH injected into the dorsal motor nucleus of the vagus (DMN) elicited a significant increase in gastric motility while the same quantity of oxytocin elicited a reduction in phasic contractile activity and tone. The action of these peptides mimics the excitatory and inhibitory effects of stimulating the paraventricular nucleus of the hypothalamus (PVN); it is likely that this hypothalamic structure regulates gastric function through its peptidergic connections with medullary vagal structures. This hypothesis is supported by our observations that injections of an oxytocin antagonist into the DMN produced a disinhibition of gastric motility and an increase in the motility evoked by subsequent PVN stimulation. Vagotomy eliminated all subsequent central effects on motility of these peptides.
journal_name
Peptidesjournal_title
Peptidesauthors
Rogers RC,Hermann GEdoi
10.1016/0196-9781(87)90017-9subject
Has Abstractpub_date
1987-05-01 00:00:00pages
505-13issue
3eissn
0196-9781issn
1873-5169pii
0196-9781(87)90017-9journal_volume
8pub_type
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