Exploiting endogenous opioids: Lessons learned from endomorphin 2 in the female rat.

Abstract:

:Effective management of chronic pain is demanded by ethical as well as medical considerations. Although opioid analgesics remain among the most effective pharmacotherapies for ameliorating many types of pain, their use is clouded by concerns regarding their addictive properties, underscored by the current epidemic of prescription opioid abuse and attendant deaths. Medicinal harnessing of endogenous opioid antinociception could provide a strategy for continuing to take advantage of the powerful antinociceptive properties of opioids while avoiding their abuse potential. Based on our studies of endogenous mechanism that suppress and facilitate spinal endomorphin 2 antinociception over the rat reproductive cycle, we identified multiple signaling molecules that could serve as targets for activating endogenous opioid analgesia for chronic pain management in women. Our findings emphasize the need for a precision medicine approach that includes stage of menstrual cycle as an important determinant of drug targets for (activating/harnessing) endogenous opioid antinociceptive systems/ capabilities. Utilization of drugs that harness endogenous opioid antinociception in accordance with varying physiological states represents a novel approach for effective pain management.

journal_name

Peptides

journal_title

Peptides

authors

Gintzler AR,Liu NJ,Storman EM,Wessendorf MW

doi

10.1016/j.peptides.2018.12.002

subject

Has Abstract

pub_date

2019-02-01 00:00:00

pages

133-138

eissn

0196-9781

issn

1873-5169

pii

S0196-9781(18)30244-4

journal_volume

112

pub_type

杂志文章,评审

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