Abstract:
:The in vitro activity of six polycationic peptides, buforin II, cecropin P1, indolicidin, magainin II, nisin, and ranalexin, were evaluated against several clinical isolates of gram-positive and gram-negative aerobic bacteria, yeasts, Pneumocystis carinii and Cryptosporidium parvum, by using microbroth dilution methods. The peptides exhibited different antibacterial activities and rapid time-dependent killing. The gram-negative organisms were more susceptible to buforin II and cecropin P1, whereas buforin II and ranalexin were the most active compounds against the gram-positive strains. Similarly, ranalexin showed the highest activity against Candida spp., whereas magainin II exerted the highest anticryptococcal activity. Finally, the peptides showed high anti-Pneumocystis activity, whereas no compound had strong inhibitory effect on C. parvum.
journal_name
Peptidesjournal_title
Peptidesauthors
Giacometti A,Cirioni O,Barchiesi F,Del Prete MS,Scalise Gdoi
10.1016/s0196-9781(99)00131-xsubject
Has Abstractpub_date
1999-11-01 00:00:00pages
1265-73issue
11eissn
0196-9781issn
1873-5169pii
S0196-9781(99)00131-Xjournal_volume
20pub_type
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