Abstract:
:Energy homeostasis is controlled by a complex neuroendocrine system consisting of peripheral signals like leptin and central signals, in particular, neuropeptides. Several neuropeptides with anorexigenic (POMC, CART, and CRH) as well as orexigenic (NPY, AgRP, and MCH) actions are involved in this complex (partly redundant) controlling system. Starvation as well as overfeeding lead to changes in expression levels of these neuropeptides, which act downstream of leptin, resulting in a physiological response. In this review the role of several anorexigenic and orexigenic (hypothalamic) neuropeptides on food intake and body weight regulation is summarized.
journal_name
Peptidesjournal_title
Peptidesauthors
Hillebrand JJ,de Wied D,Adan RAdoi
10.1016/s0196-9781(02)00269-3subject
Has Abstractpub_date
2002-12-01 00:00:00pages
2283-306issue
12eissn
0196-9781issn
1873-5169pii
S0196978102002693journal_volume
23pub_type
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