Abstract:
:Pretreatment with opioid antagonists enhances acquisition of Pavlovian fear conditioning. The present experiments attempted to characterize the type of opioid receptor responsible for this effect using a procedure that assessed the fear of rats to a chamber previously associated with electric shock (1 mA, 0.75 s). Freezing, a species-typical immobility, was employed as an index of fear. Two mu opioid antagonists, CTOP (40 ng) and naloxonazine (10 micrograms), enhanced conditioning. On the other hand, the kappa antagonist nor-binaltorphimine reduced conditioning. Two delta antagonist treatments (16-methyl cyprenorphine and naltrindole) had no reliable effect on acquisition. Thus the enhancement of conditioning appears to be mediated by mu receptors. Previous research has shown that the conditional fear produced by these procedures caused an analgesia that is also mediated by mu receptors. It is argued that the enhancement effect occurs because of an antagonism of this analgesia and that the analgesia normally acts to regulate the level of fear conditioning.
journal_name
Peptidesjournal_title
Peptidesauthors
Fanselow MS,Kim JJ,Young SL,Calcagnetti DJ,DeCola JP,Helmstetter FJ,Landeira-Fernandez Jdoi
10.1016/0196-9781(91)90056-usubject
Has Abstractpub_date
1991-09-01 00:00:00pages
1033-7issue
5eissn
0196-9781issn
1873-5169pii
0196-9781(91)90056-Ujournal_volume
12pub_type
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