Abstract:
:The effects of dipeptide cyclo-[His-Pro] (CHP), known to participate in the appetite behavior and food intake control, have been investigated using PC12 cells in culture as model system. We found that only in the presence of experimental conditions that cause cellular stress the cyclic dipeptide affect cellular proliferation and protects from apoptosis. It greatly enhances the phosphorylation of hsp27, alpha-B-crystallin, Cdc2, and p-38 MAPK, whereas it decreases the phosphorylation of MEK1, Cav 2, GSK3a, PKB/Akt, PKCdelta, PKCgamma, and Erk2. PKA and PKG are involved in ERK1/2 deactivation via a receptor that appears to be dually coupled to Gs and Gq protein subfamilies.
journal_name
Peptidesjournal_title
Peptidesauthors
Minelli A,Bellezza I,Grottelli S,Pinnen F,Brunetti L,Vacca Mdoi
10.1016/j.peptides.2005.07.010subject
Has Abstractpub_date
2006-01-01 00:00:00pages
105-13issue
1eissn
0196-9781issn
1873-5169pii
S0196-9781(05)00345-1journal_volume
27pub_type
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