Neurotrophic effects of PACAP in the cerebellar cortex.

abstract：:Prolactin releasing peptide (PrRP) was originally reported to act in the anterior lobe of the pituitary gland to stimulate prolactin (PRL) release; however, numerous other pharmacologic actions of PrRP have been described. In the central nervous system PrRP inhibits food intake, stimulates sympathetic tone, and activa...

journal_title：Peptides

authors： Samson WK,Taylor MM

更新日期：2006-05-01 00:00:00

abstract：:Unilateral intracerebroventricular (ICV) injections of a high dose of CCK7 have been reported to elicit barrel rotations accompanied by contralateral postural asymmetry; there was no spontaneous locomotor activity other than barrel rolling. The aim of the present study was to investigate the effects of lower doses of ...

journal_title：Peptides

authors： Morency MA,Ross GM,Hesketh D,Mishra RK

更新日期：1987-11-01 00:00:00

abstract：:Kallikrein-related peptidases (KLKs) are a group of serine proteases, expressed in several tissues. Their activity is regulated by inhibitors including members of the serine protease of Kazal-type (SPINK) family. Recently, we discovered that SPINK6 is expressed in human skin and inhibits KLK5, KLK7, KLK14 but not KLK8...

journal_title：Peptides

authors： Kantyka T,Fischer J,Wu Z,Declercq W,Reiss K,Schröder JM,Meyer-Hoffert U

更新日期：2011-06-01 00:00:00

abstract：:In the cephalopod mollusk Octopus vulgaris, the gonadotropic hormone released by the optic gland controls sexual maturity. Several lobes of the central nervous system control the activity of this gland. In one of these lobes, the olfactory lobe, a gonadotropin releasing hormone (GnRH) neuronal system has been describe...

journal_title：Peptides

authors： Di Cristo C,De Lisa E,Di Cosmo A

更新日期：2009-03-01 00:00:00

abstract：:In the crayfish Astacus leptodactylus, as in several crustacean species, the crustacean hyperglycemic hormone is present as two isoforms differing by the chirality of the third residue, a phenylalanine. In the present work, isoforms synthesized full length by solid-phase peptide synthesis have been purified, refolded,...

journal_title：Peptides

authors： Lebaupain F,Boscameric M,Pilet E,Soyez D,Kamech N

更新日期：2012-03-01 00:00:00

abstract：:The aim of this study was to investigate peripheral and central roles of corticotropin-releasing factor (CRF) in endocrinological and behavioral changes. Plasma adrenocorticotropin (ACTH) concentration was measured as an activity of hypothalamic-pituitary-adrenal (HPA) axis. As behavioral changes, locomotion and anxie...

journal_title：Peptides

authors： Tanaka M,Tomimatsu Y,Sakimura K,Ootani Y,Sako Y,Kojima T,Aso K,Yano T,Hirai K

更新日期：2017-09-01 00:00:00

abstract：:Bradykinin-potentiating peptides from Bothrops jararaca (Bj) discovered in the early 1960s, were the first natural inhibitors of the angiotensin-converting enzyme (ACE). These peptides belong to a large family of snake venom proline-rich oligopeptides (PROs). One of these peptides, Bj-PRO-9a, was essential for definin...

journal_title：Peptides

authors： Morais KL,Ianzer D,Miranda JR,Melo RL,Guerreiro JR,Santos RA,Ulrich H,Lameu C

更新日期：2013-10-01 00:00:00

abstract：:The objective of this study was to explore the effects of the endogenous opioid peptide dynorphin A(1-13) on the CNS regulation of blood pressure and heart rate. Wistar rats, anesthetized with pentobarbital and halothane, received dynorphin A(1-13) microinjected into the anterior hypothalamus area (AHA), the posterior...

journal_title：Peptides

authors： Rabkin SW

更新日期：1993-11-01 00:00:00

abstract：:Oxyntomodulin (OXM), a 37-amino acid glucagon-containing peptide produced mainly in intestine and endocrine pancreas, is present in rat plasma and inhibits pentagastrin-stimulated gastric acid secretion in both the anesthetized and the conscious rat. In order to investigate the modifications in acid and water secretio...

journal_title：Peptides

authors： Jarrousse C,Niel H,Audousset-Puech MP,Martinez J,Bataille D

更新日期：1986-01-01 00:00:00

abstract：:We have developed a semi-intact preparation-consisting of an isolated oviduct with abdominal ganglia VII and VIII intact and attached-with which to characterize the effects on oviduct contraction, of peptides that are bath applied to CNS tissues. The work presented here offers a qualitative analysis of the central eff...

journal_title：Peptides

authors： Kwok R,Orchard I

更新日期：2002-11-01 00:00:00

abstract：:We examined the effects of tumor necrosis factor (TNF)-alpha on the expression and functionality of adrenomedullin (AM) receptors in cultured human coronary artery smooth muscle cells. Analysis of real-time quantitative polymerase chain reactions showed that these cells abundantly express two AM receptors comprised of...

journal_title：Peptides

authors： Nagoshi Y,Kuwasako K,Cao YN,Imamura T,Kitamura K,Eto T

更新日期：2004-07-01 00:00:00

abstract：:ACTH/MSH(4-10) (10 micrograms/kg/b.i.d.; IP), administered to pregnant Sprague-Dawley rats during gestational days (GD) 3 to 12, significantly increased the metabolic activity of extensor digitorum longus (EDL) muscle at postnatal day 14. ACTH/MSH peptide, administered from day of birth to postnatal day 13, had no eff...

journal_title：Peptides

authors： Rose KJ,Strand FL

更新日期：1990-01-01 00:00:00

abstract：:Adrenomedullin (ADM) is a hypotensive peptide, originally isolated from human pheochromocytomas, and then found to be widely distributed in the various body systems. ADM derives from preproadrenomedullin, a 185-amino acid residue prohormone, containing at its N-terminal a 20-amino acid sequence, named proadrenomedulli...

journal_title：Peptides

authors： Nussdorfer GG,Rossi GP,Mazzocchi G

更新日期：1997-01-01 00:00:00

abstract：:Animal behavioral and neurochemical studies implicate dopaminergic systems in the neurological sequelae induced by estrogen. In the present study, we demonstrated for the first time that MIF-1, a neuropeptide unrelated to classical dopamine agonists, when given prior to, concurrently with, and after 17 beta-estradiol,...

journal_title：Peptides

authors： Rajakumar G,Chiu P,Chiu S,Johnson RL,Mishra RK

更新日期：1987-11-01 00:00:00

abstract：:A newly developed system of isolated rat colonic epithelial cells was utilized for a comprehensive study of protein synthesis influenced by gastrin. We found that synthetic human gastrin (0.01-100 nM) increased the incorporation of [35S]methionine into proteins within 2 hours. Peak incorporation was observed with 10 n...

journal_title：Peptides

authors： Yassin RR,Clearfield HR,Katz SM,Murthy SN

更新日期：1991-01-01 00:00:00

abstract：:Recent reports suggest that arginine vasopressin (AVP) may be an endogenous antipyretic peptide and a mediator of febrile convulsions [10,12]. The spontaneously seizing Mongolian gerbil was used to investigate the thermoregulatory, behavioral and seizure modulatory effects of AVP. Injection of AVP (1.0 and 5.0 microgr...

journal_title：Peptides

authors： Lee RJ,Lomax P

更新日期：1983-11-01 00:00:00

abstract：:Immunohistochemical localization of Met-enkephalin, Met-enkephalin-Arg6-Gly7-Leu8, Met-enkephalin-Arg6-Phe7 and Leu-enkephalin was studied in human adrenal medulla and pheochromocytomas at the light and electron microscopic levels. Both adrenal medulla and pheochromocytomas (4 adrenal, 1 extra-adrenal) showed scattere...

journal_title：Peptides

authors： Osamura RY,Watanabe K,Yoshimasa T,Nakao K,Imura H

更新日期：1984-09-01 00:00:00

abstract：:The multifunctional arthropod 'insect kinins' share the evolutionarily conserved C-terminal pentapeptide motif Phe-X1-X2-Trp-Gly-NH2, where X1=His, Asn, Ser, or Tyr and X2=Ser, Pro, or Ala. Eight different analogs of the insect kinin C-terminal pentapeptide active core in which the critical residues Phe 1, Pro3 and Tr...

journal_title：Peptides

authors： Taneja-Bageshwar S,Strey A,Zubrzak P,Williams H,Reyes-Rangel G,Juaristi E,Pietrantonio P,Nachman RJ

更新日期：2008-02-01 00:00:00

abstract：:Obestatin regulates fluid and electrolyte homeostasis mainly by opposing the action of vasopressin (AVP). We measured plasma concentration of obestatin and AVP in patients with cardiorenal syndrome (CRS). Plasma AVP and obestatin concentration were measured in 34 patients with type II CRS. The data were compared to th...

journal_title：Peptides

authors： Shi JB,Guo ZF,Zheng X,Wang ZB,Ma YJ

更新日期：2012-12-01 00:00:00

abstract：:Central nervous systems of the pond snail Lymnaea stagnalis were incubated in vitro in different concentrations of ORG 2766 (10(-9)-2.5 x 10(-4) M) for 10 and 20 h. Quantitative ultrastructural study of cross sections of the cerebral commissure showed that the number of microtubules in large axons had increased after ...

journal_title：Peptides

authors： Müller LJ,Moorer-van Delft CM,Boer HH

更新日期：1992-07-01 00:00:00

abstract：:The in vitro interaction between five polycationic peptides, buforin II, cecropin P1, indolicidin, magainin II, and ranalexin, and several clinically used antimicrobial agents was evaluated against several clinical isolates of Gram-positive and Gram-negative aerobic bacteria, using the microbroth dilution method. The ...

journal_title：Peptides

authors： Giacometti A,Cirioni O,Del Prete MS,Paggi AM,D'Errico MM,Scalise G

更新日期：2000-08-01 00:00:00

abstract：:Short cell penetrating peptides (CPP) are widely used in vitro to transduce agents into cells. But their systemic effect has not been yet studied in detail. We studied the systemic effect of the cell penetrating peptides, penetratin, transportan and pro-rich, on rat hemodynamic functions. Intra-arterial monitoring of ...

journal_title：Peptides

authors： Basheer M,Schwalb H,Shefler I,Levdansky L,Mekori YA,Gorodetsky R

更新日期：2011-12-01 00:00:00

abstract：:We investigated the effect of synthetic antimicrobial decapeptide KSL-W (KKVVFWVKFK) on normal human gingival fibroblast growth, migration, collagen gel contraction, and α-smooth muscle actin protein expression. Results show that in addition to promoting fibroblast adhesion by increasing F-actin production, peptide KS...

journal_title：Peptides

authors： Park HJ,Salem M,Semlali A,Leung KP,Rouabhia M

更新日期：2017-07-01 00:00:00

abstract：:PACAP-27 and PACAP-38 are the exclusive physiological ligands for the mammalian PAC1 receptor. The role of C-terminal amidation of these ligands at that receptor was examined in neuroendocrine cells expressing the PAC1 receptor endogenously and in non-neuroendocrine cells in which the human and rat PAC1 receptors were...

journal_title：Peptides

authors： Emery AC,Alvarez RA,Abboud P,Xu W,Westover CD,Eiden MV,Eiden LE

更新日期：2016-05-01 00:00:00

abstract：:To determine the functional role for and the pharmacological specificity of developing gastrointestinal CCK receptors, in vitro pyloric contractility and autoradiographic CCK receptor binding were examined in pups aged 1-20 days. CCK contracted the gastroduodenal junction at all ages, while nonsulfated CCK-8 (d-CCK) w...

journal_title：Peptides

authors： Schwartz GJ,Moran TH,McHugh PR

更新日期：1990-11-01 00:00:00

abstract：:Humanin (HN) and HN-derivatives are a family of peptides first reported in the last decade with potent in vitro and in vivo neuroprotective activity, which is mediated through a not completely elucidated mechanism. Recently, our group has evaluated the effect of various HN-derivatives on the 3-quinuclidinyl benzilate ...

journal_title：Peptides

authors： Evangelou A,Zikos C,Benaki D,Pelecanou M,Bouziotis P,Papadopoulos M,Borovickova L,Vesela I,Elbert T,Kunesová G,Pirmettis I,Paravatou-Petsotas M,Slaninová J,Livaniou E

更新日期：2009-12-01 00:00:00

abstract：:Four potent angiotensin converting enzyme (ACE) inhibitory peptides, IY, RIY, VW and VWIS, were isolated from subtilisin digest of rapeseed protein. Among them RIY and VWIS are new peptides with IC(50) 28 and 30 microM, respectively. All isolated peptides lowered blood pressure of spontaneously hypertensive rats (SHR)...

journal_title：Peptides

authors： Marczak ED,Usui H,Fujita H,Yang Y,Yokoo M,Lipkowski AW,Yoshikawa M

更新日期：2003-06-01 00:00:00

abstract：:Opioid-like immunoreactive material was extracted from the pituitary and brain of the Spiny Dogfish Shark Squalus acanthias. The immunoreactive material in the pituitary extracts was purified to apparent homogeneity by reverse phase high performance liquid chromatography and subsequently characterized by amino acid an...

journal_title：Peptides

authors： Lorenz RG,Tyler AN,Faull KF,Makk G,Barchas JD,Evans CJ

更新日期：1986-01-01 00:00:00

abstract：:The gut tissues and associated nervous system of the African migratory locust, Locusta migratoria, were found to contain FMRFamide-like immunoreactive (FLI) material throughout the five larval instars and 2 weeks into the adult stage in both males and females. FMRFamide-like immunoreactivity associated with the locust...

journal_title：Peptides

authors： Hill SR,Orchard I

更新日期：2003-10-01 00:00:00

abstract：:Although previous studies have implicated NPY in the etiology of experimental cancer anorexia, the results have been difficult to interpret. Studies have suggested that although NPY level and message were decreased in the dorsomedial hypothalamic area (DMA), they were elevated in the ventromedial hypothalamic area (VM...

journal_title：Peptides

authors： Chance WT,Xiao C,Dayal R,Sheriff S

更新日期：2007-02-01 00:00:00