Abstract:
:Recent reports suggest that arginine vasopressin (AVP) may be an endogenous antipyretic peptide and a mediator of febrile convulsions [10,12]. The spontaneously seizing Mongolian gerbil was used to investigate the thermoregulatory, behavioral and seizure modulatory effects of AVP. Injection of AVP (1.0 and 5.0 micrograms IV and 0.01-1.0 mg/kg SC) caused dose-related falls in body temperature. Stereotypic scratching, terminated by a body shake, was observed after AVP (1.0-5.0 micrograms IV). However, such behavior was not observed after subcutaneous injection of AVP. AVP did not potentiate seizure induction in the gerbils but rather reduced the seizure incidence. The data demonstrate that AVP can reduce body temperature and cause specific behaviors, but it does not appear to play a role in the pathogenesis of seizures in the seizure sensitive strain of Mongolian gerbil.
journal_name
Peptidesjournal_title
Peptidesauthors
Lee RJ,Lomax Pdoi
10.1016/0196-9781(83)90070-0subject
Has Abstractpub_date
1983-11-01 00:00:00pages
801-5issue
6eissn
0196-9781issn
1873-5169pii
0196-9781(83)90070-0journal_volume
4pub_type
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