Antimicrobial peptide KSL-W promotes gingival fibroblast healing properties in vitro.

abstract：:As a novel vasoactive peptide, plasma coupling factor 6 (CF6) was shown to be elevated in patients with diabetes mellitus, yet the mechanism involved is unknown. We studied CF6 protein release and its potential mechanism in human umbilical vein endothelial cells (HUVECs) incubated with high glucose levels. High glucos...

journal_title：Peptides

authors： Li X,Xing S,Zhang L,Xing Q,Yan S,Dai H,You S,Pang Y,Tang C

更新日期：2007-03-01 00:00:00

abstract：:The striatum is richly innervated by both enkephalinergic and dopaminergic neurons, providing an anatomic framework from which intimate functional interrelationships between these neuronal systems may be postulated. Accordingly, many functional processes within dopamine neurons have been shown to be modulated by opioi...

journal_title：Peptides

authors： George SR,Kertesz M

更新日期：1987-05-01 00:00:00

abstract：:The heptadecapeptide, orphanin FQ or nociceptin (Phe-Gly-Phe-Thr-Gly-Ala-Arg-Lys-Ser-Ala-Arg-Lys-Leu-Ala-Asn-Gln), originally isolated from rat brain has been identified as an endogenous ligand for the orphan opioid-like receptor. Although orphanin FQ shares some sequence and structural homology with kappa-opioid pept...

journal_title：Peptides

authors： Kavaliers M,Choleris E,Saucier DM

更新日期：1997-01-01 00:00:00

abstract：:Pituitary Adenylate-Cyclase Activating Polypeptide (PACAP) and Tac1 gene-encoded tachykinins (substance P: SP, neurokinin A: NKA) are expressed in capsaicin-sensitive nerves, but their role in nociception, inflammation and vasoregulation is unclear. Therefore, we investigated the function of these neuropeptides and th...

journal_title：Peptides

authors： Botz B,Imreh A,Sándor K,Elekes K,Szolcsányi J,Reglődi D,Quinn JP,Stewart J,Zimmer A,Hashimoto H,Helyes Z

更新日期：2013-05-01 00:00:00

abstract：:Methods have been developed for the microsurgical interruption of nerve pathways in the wall of the intestine and for the immunohistochemical localization of antigens in whole mounts. These methods have made it possible to determine accurately the distributions and projections of neurons containing different putative ...

journal_title：Peptides

authors： Furness JB,Costa M,Llewellyn-Smith IJ

更新日期：1981-01-01 00:00:00

abstract：:Besides its well known endocrinological effects, thyrotropin-releasing hormone (TRH) has potential clinical value in the treatment of neurotrauma and various neurologic and psychiatric disorders. The aim of this study was to assess if transdermal delivery of TRH and its analogue, M-TRH, in the presence of enhancers, i...

journal_title：Peptides

authors： Magnusson BM,Koskinen LO,Koch M,Karlsson K

更新日期：2001-01-01 00:00:00

abstract：:Recent studies have provided evidence for the dense localization of atrial natriuretic factor (ANF) in the anteroventral third ventricle (AV3V) region of the rat brain. This area is currently thought to be involved in the regulation of blood pressure and fluid and electrolyte balance. To investigate whether ANF may pl...

journal_title：Peptides

authors： Sills MA,Nguyen KQ,Jacobowitz DM

更新日期：1985-11-01 00:00:00

abstract：:Atrial natriuretic peptide (ANP) is increasingly expressed on airway and inhibits pulmonary arterial remodeling. However, the role of ANP in remodeling of respiratory system is still unclear. The role of ANP on airway remodeling and the possible mechanism was explored in this study. Both human bronchial epithelial 16H...

journal_title：Peptides

authors： Chu S,Zhang X,Sun Y,Yu Y,Liang Y,Jiang M,Huang J,Ma L

更新日期：2017-04-01 00:00:00

abstract：:Acute and chronic effects of gamma-butyrolactone-gamma-carbonyl-histidyl-prolinamide (DN-1417) were investigated on motor activity, dopamine (DA) metabolites and DA receptors in various brain regions of rats. The motor activity, as measured with Automex recorder, was enhanced after a single injection with DN-1417 (20 ...

journal_title：Peptides

authors： Nakahara T,Matsumoto T,Hirano M,Uchimura H,Yokoo H,Nakamura K,Ishibashi K,Hirano H

更新日期：1985-11-01 00:00:00

abstract：:Atriopeptins are circulating peptide hormones which are secreted by atrial tissue and act at the kidney. Because the atriopeptins survive passage through the pulmonary circulation, they also may be involved in the modulation of airway or pulmonary vascular smooth muscle tone. Using in vitro organ bath techniques, atri...

journal_title：Peptides

authors： O'Donnell M,Garippa R,Welton AF

更新日期：1985-07-01 00:00:00

abstract：:Vasoactive intestinal peptide (VIP) enhances angiogenesis in rats with focal cerebral ischemia. In the present study, we investigated the molecular mechanism of the proangiogenic action of VIP using an in vitro ischemic model, in which rat brain microvascular endothelial cells (RBMECs) are subjected to oxygen and gluc...

journal_title：Peptides

authors： Yang J,Shi QD,Song TB,Feng GF,Zang WJ,Zong CH,Chang L

更新日期：2013-04-01 00:00:00

abstract：:Insulin-like peptides (ILPs) affect a wide variety of biological events, such as metabolism, lifespan, growth and reproduction. Two ILPs (Spoli-ILP1 and Spoli-ILP2) were identified in the cotton leafworm, Spodoptera littoralis, while the functions and developmental characters are not fully understood. In the present s...

journal_title：Peptides

authors： Iga M,Smagghe G

更新日期：2011-03-01 00:00:00

abstract：:Given the importance of G-protein coupled receptors in the regulation of many physiological functions, deciphering the relationships between genotype and phenotype in past and present hominin GPCRs is of main interest to understand the evolutionary process that contributed to the present-day variability in human trait...

journal_title：Peptides

authors： Mata X,Renaud G,Mollereau C

更新日期：2019-12-01 00:00:00

abstract：:Neuropeptide S (NPS), the endogenous ligand of NPS receptor (NPSR), regulates many biological functions, including arousal, anxiety, locomotion and food intake. NPSR mRNA is expressed in several regions of central autonomic network through which the brain controls visceromotor and other responses essential for surviva...

journal_title：Peptides

authors： Han RW,Chang M,Peng YL,Qiao LY,Yin XQ,Li W,Wang R

更新日期：2009-07-01 00:00:00

abstract：:A large body of evidence suggests a relationship between depression and coronary heart disease (CHD). Angiotensin-Ⅱ (Ang-Ⅱ) and angiotensin-(1-7) [Ang-(1-7)] are considered to exert biological effects in both conditions. Here, we aimed to determine the role of Ang-Ⅱ and Ang-(1-7) in the occurrence of comorbid depressi...

journal_title：Peptides

authors： Han W,Wei Z,Dang R,Guo Y,Zhang H,Geng C,Wang C,Feng Q,Jiang P

更新日期：2020-09-01 00:00:00

abstract：:The amidated beta-casomorphin morphiceptin Tyr-Pro-Phe-Pro-NH2 is an opioid peptide isolated from bovine milk beta-casein digests whose physiological significance remains unclear. Opiates are known to modify intestinal electrolyte transport by acting on receptors located on the serosal side of the intestine. The aim o...

journal_title：Peptides

authors： Mahe S,Tome D,Dumontier AM,Desjeux JF

更新日期：1989-01-01 00:00:00

abstract：:Diadenosine polyphosphates (APnAs) are endogenous compounds and exert diverse cardiovascular functions. However, the effects of APnAs on atrial ANP release and contractility have not been studied. In this study, the effects of diadenosine tetraphosphate (AP4A) on atrial ANP release and contractility, and their mechani...

journal_title：Peptides

authors： Yuan K,Cao C,Bai GY,Kim SZ,Kim SH

更新日期：2007-07-01 00:00:00

abstract：:Antimicrobial peptides produced by multicellular organisms protect against pathogenic microorganisms, whereas such peptides produced by bacteria provide an ecological advantage over competitors. Certain antimicrobial peptides of metazoan origin are also toxic to eukaryotic cells, with preference for a variety of cance...

journal_title：Peptides

authors： Sand SL,Oppegård C,Ohara S,Iijima T,Naderi S,Blomhoff HK,Nissen-Meyer J,Sand O

更新日期：2010-07-01 00:00:00

abstract：:Cholecystokinin induces a reduction in exploratory behaviors which could reflect an underlying behavioral state of either satiety or malaise. To investigate these alternative hypotheses, the effects of CCK were compared to the effects of (a) consumption of an extra quantity of palatable food, of (b) bombesin at doses ...

journal_title：Peptides

authors： Crawley JN

更新日期：1983-07-01 00:00:00

abstract：:Gastrin-releasing peptide (GRP) has been implicated in the itch-scratch cycle. We investigated if this gut-brain-skin peptide plays a role in the compulsive, hindleg scratching of the neck of mice by 5'-guanidinonaltrindole (GNTI), the kappa opioid receptor antagonist, and in the antipruritic activity of nalfurafine, ...

journal_title：Peptides

authors： Inan S,Dun NJ,Cowan A

更新日期：2011-02-01 00:00:00

abstract：:A comparison of the conformational characteristics of the related hormones [Nle(15)] gastrin-17 and [Tyr(9)-SO(3)] cholecystokinin-15, in membrane-mimetic solutions of dodecylphosphocholine micelles and water, was undertaken using NMR spectroscopy to investigate the possibility of a structural motif responsible for th...

journal_title：Peptides

authors： Stone SR,Giragossian C,Mierke DF,Jackson GE

更新日期：2007-11-01 00:00:00

abstract：:The effect and mode of action of pituitary adenylate cyclase activating polypeptide (PACAP) were studied in rat ileal strips. PACAP relaxed, concentration dependently, rat ileum and was 50 times more potent than the structurally related vasoactive intestinal polypeptide (VIP). The inhibitory action of PACAP was not mo...

journal_title：Peptides

authors： Katsoulis S,Clemens A,Schwörer H,Creutzfeldt W,Schmidt WE

更新日期：1993-05-01 00:00:00

abstract：:A study was made of the effect of adrenalectomy over different periods of time (6, 15 and 21 days) on exocrine pancreatic secretion in the rat in basal conditions and under stimulation with CCK. It was observed that adrenalectomy does not alter the rate of pancreatic flow but the response capacity to CCK is depressed....

journal_title：Peptides

authors： Manso MA,De Dios I,Garcia AM,Calvo JJ

更新日期：1988-05-01 00:00:00

abstract：:Rats were injected IP with a 0.1 mg/kg dose of MIF-I, naloxone, dynorphin, [D-Phe4]-Met-enkephalin, [D-Ala2, F5Phe4]-Met-enkephalin-NH2, or the diluent vehicle, placed in their home cages for ten minutes, and then given ad lib access to either 20% sucrose, 10% sucrose, water, 0.01% quinine, or 0.02% quinine in a repea...

journal_title：Peptides

authors： Olson RD,Kastin AJ,Olson GA,King BM,Von Almen TK,Berzas MC,Ibanez ML,Coy DH

更新日期：1980-01-01 00:00:00

abstract：:The relaxant effect of a novel VIP analog, [Arg15,20,21Leu17]-VIP-Gly-Lys-Arg-NH2 was compared with that of the original VIP in the same guinea pig trachea precontracted by carbachol in vitro. The VIP analog caused significantly and concentration-dependent relaxation similarly to the original VIP. In contrast to the o...

journal_title：Peptides

authors： Yoshihara S,Lindén A,Kashimoto K,Watanabe S

更新日期：1998-01-01 00:00:00

abstract：:The hypocretins (1 and 2) have emerged as key regulators of sleep and wakefulness. We developed a high-throughput enzyme immunoassay (EIA) to measure total brain hypocretin levels from large numbers of mice. Hypocretin levels were not altered by circadian time or age. However, significant differences in one or both hy...

journal_title：Peptides

authors： Lin L,Wisor J,Shiba T,Taheri S,Yanai K,Wurts S,Lin X,Vitaterna M,Takahashi J,Lovenberg TW,Koehl M,Uhl G,Nishino S,Mignot E

更新日期：2002-12-01 00:00:00

abstract：:Antimicrobial peptides (AMPs) are believed to be a promising class of antimicrobial agents against bacteria and fungi. To promote the clinical use of AMPs, their antimicrobial activity and susceptibility to protease degradation should be further improved. The antimicrobial peptide Jelleine-I was originally isolated fr...

journal_title：Peptides

authors： Jia F,Zhang Y,Wang J,Peng J,Zhao P,Zhang L,Yao H,Ni J,Wang K

更新日期：2019-02-01 00:00:00

abstract：:In this study, we evaluated the bradykinin potentiating activity and ACE inhibitory activity of several Ang-(1-7)-related peptides: Ang-(2-7), Ang-(3-7), Ang-(4-7), Ang-(1-6), Ang-(1-5) and the selective antagonist of Ang-(1-7): D-[Ala7]Ang-(1-7) (A-779). In vivo experiments were performed in freely moving Wistar rats...

journal_title：Peptides

authors： Paula RD,Lima CV,Britto RR,Campagnole-Santos MJ,Khosla MC,Santos RA

更新日期：1999-01-01 00:00:00

abstract：:To investigate possible influences of growth hormone-releasing hormone (GHRH) and somatostatin (SRIF) on auditory perceptional processes, 12 subjects received either placebo (sodium chloride 0.9%), GHRH (50 micrograms), or SRIF (100 micrograms) on different days. Late auditory evoked potentials (AEP) were computed and...

journal_title：Peptides

authors： Hartmann A,Dietl T,Krumrey K,Vogl L,Dirlich G,Holsboer F,Heuser-Link M

更新日期：1995-01-01 00:00:00

abstract：:Cholecystokinin (CCK) is widely distributed in the brain and is known to affect behavioral and physiological functions including anxiety and pain. The expression of CCK has been shown to be regulated by estrogen and to vary during the estrous cycle in rat brain. In the present study CCK was determined in plasma from 2...

journal_title：Peptides

authors： Lundberg K,Hilke S,Nordin C,Theodorsson E,Josefsson A

更新日期：2010-08-01 00:00:00