Immunohistochemical localization of Met-enkephalin, Met-enkephalin-Arg6-Gly7-Leu8, Met-enkephalin-Arg6-Phe7 and Leu-enkephalin in human adrenal medulla and pheochromocytomas.

abstract：:Large species differences have been previously observed in the pharmacology of bradykinin (BK) B2 receptor antagonists. We investigated the effect of two novel non-peptide antagonists, compound 9 (a benzodiazepine peptidomimetic related to icatibant) and the thiosemicarbazide bradyzide on the rabbit B2 receptor (contr...

journal_title：Peptides

authors： Marceau F,Houle S,Bouthillier J,Said NB,Garratt PJ,Dziadulewicz EK

更新日期：2001-09-01 00:00:00

abstract：:The role of neuropeptides in cardiomyopathy-associated heart failure has been garnering more attention. Several neuropeptides--Neuropeptide Y (NPY), vasoactive intestinal peptide (VIP), calcitonin gene related peptide (CGRP), substance P (SP) and their receptors have been studied in the various types of cardiomyopathi...

journal_title：Peptides

authors： Dvorakova MC,Kruzliak P,Rabkin SW

更新日期：2014-11-01 00:00:00

abstract：:The central effect of cholecystokinin-octapeptide (CCK), SQ 19,844 or sincalide, on the intake of food and water and on colonic temperature (Tc) was investigated using the broiler cockerel. Four-week old chicks were maintained in a thermoneutral environment of 23-24 degrees C. After food was removed for a 24 hr interv...

journal_title：Peptides

authors： Denbow DM,Myers RD

更新日期：1982-09-01 00:00:00

abstract：:We have developed a specific and sensitive radioimmunoassay for the hydra head activator neuropeptide (HHAP). The antibody recognizes the C-terminal portion of HHAP and shows no cross-reactivity with other neuropeptides. The assay allows measurement of HHAP-like material in tissue extracts with a minimum detectable co...

journal_title：Peptides

authors： Ekman R,Salford L,Brun A,Larsson I

更新日期：1990-03-01 00:00:00

abstract：:The decapeptide from the frog Hyla caerulea, caerulein (caerulein diethylammonium hydrate, ceruletide, CER) is chemically closely related to the C-terminal octapeptide of cholecystokinin (CCK-8). Like CCK-8, CER and some of its analogues produce many behavioural effects in mammals: inhibition of intake of food and wat...

journal_title：Peptides

authors： Zetler G

更新日期：1985-01-01 00:00:00

abstract：:A novel antimicrobial peptide, with molecular mass of 1602.0469Da, produced by Brevibacillus laterosporus strain A60 was isolated and purified from the soil of mango plants. The purification procedure consisted of ammonium sulfate precipitation, cation exchange chromatography on an HiTrap SP HP column, thin layer chro...

journal_title：Peptides

authors： Zhao J,Guo L,Zeng H,Yang X,Yuan J,Shi H,Xiong Y,Chen M,Han L,Qiu D

更新日期：2012-02-01 00:00:00

abstract：:The synthesis is described of an analogue of the locust CRF-like diuretic peptide in which methionine in positions 1,3, and 13 is replaced by isosteric methyl-homoserine residues. This analogue has been tested for biological activity on Malpighian tubules in vitro, and feeding behavior in vivo. It is highly active in ...

journal_title：Peptides

authors： Goldsworthy GJ,Chung JS,Simmonds MS,Tatari M,Varouni S,Poulos CP

更新日期：2003-10-01 00:00:00

abstract：:The prothoracicotropic hormones (PTTH) are cerebral peptides that control insect postembryonic development by stimulating the prothoracic glands to synthesize ecdysteroids. Using immunoaffinity chromatography and SDS-PAGE, a 25.5 kDa big PTTH has been purified from Manduca sexta. Based upon SDS-PAGE and Western blot a...

journal_title：Peptides

authors： Muehleisen DP,Gray RS,Katahira EJ,Thomas MK,Bollenbacher WE

更新日期：1993-05-01 00:00:00

abstract：:Alzheimer's disease is one of the most common dementia among elderly worldwide. There is no therapeutic drugs until now to treat effectively this disease. One main reason is due to the poorly understood mechanism of Aβ peptide aggregation, which plays a crucial role in the development of Alzheimer's disease. It remain...

journal_title：Peptides

authors： Tran L,Ha-Duong T

更新日期：2015-07-01 00:00:00

abstract：:Opiate binding sites in five brain regions were labeled with the mu and delta markers, 3H-morphine and 3H-[D-Ala2,D-leu5]enkephalin, respectively. The highest densities of both 3H-morphine and 3H-DADLE labeled sites are found in striatum and frontal cortex. Hypothalamus and midbrain contain predominantly 3H-morphine l...

journal_title：Peptides

authors： Hewlett WA,Barchas JD

更新日期：1983-11-01 00:00:00

abstract：:We examined the expressions of the prepro-orexin gene in the lateral hypothalamic area (LHA), the genes of the neuropeptide Y (NPY) and proopiomelanocortin (POMC) in the arcuate nucleus (ARC), the orexin type 1 receptor (OX1R) gene in the ventromedial hypothalamic nucleus (VMH) and the orexin type 2 receptor (OX2R) ge...

journal_title：Peptides

authors： Yamamoto Y,Ueta Y,Yamashita H,Asayama K,Shirahata A

更新日期：2002-09-01 00:00:00

abstract：:The melanocortin system has been implicated in a multitude of physiological pathways including obesity, satiety, energy homeostasis, sexual behavior, pigmentation, sodium regulation, hypertension, and many others. Based upon studies of the endogenous melanocortin receptor agonists at the cloned human melanocortin rece...

journal_title：Peptides

authors： Joseph CG,Yao H,Scott JW,Sorensen NB,Marnane RN,Mountjoy KG,Haskell-Luevano C

更新日期：2010-12-01 00:00:00

abstract：:I.c.v. injection for 9 days of either naltexone (NTX) (5, 10, 20, 40 micrograms/rat) or a selective mu peptide (CTOP) (0.125, 0.25, 0.5, 1, 3, 6 micrograms/rat) or delta (naltrindole) (NLT) (5, 10, 20 micrograms/rat) subtype opioid receptor antagonist affected sensitization to cocaine (COC) (50 mg/kg, i.p.) administer...

journal_title：Peptides

authors： Braida D,Paladini E,Gori E,Sala M

更新日期：1997-01-01 00:00:00

abstract：:Arginine vasopressin (AVP), which is synthesized and secreted in the hypothalamic paraventricular nucleus (PVN), is the most important bioactive substance in the pain modulation. Our pervious study had shown that AVP plays an important role in pain modulation in caudate nucleus (CdN). The experiment was designed to in...

journal_title：Peptides

authors： Yang J,Li P,Zhang XY,Zhang J,Hao F,Pan YJ,Lu GZ,Lu L,Wang DX,Wang G,Yan FL

更新日期：2011-01-01 00:00:00

abstract：:The aim of the present study was to investigate how suckling influences the plasma levels of oxytocin and vasoactive intestinal peptide in lactating dogs. Blood-samples were drawn from ten lactating beagles during suckling, in week one and week three of the five week long lactation period and the levels of vasoactive ...

journal_title：Peptides

authors： Eriksson M,Lindén A,Stock S,Uvnäs-Moberg K

更新日期：1987-05-01 00:00:00

abstract：:We compared the effects of three micro-(DAMGO, DALDA, TNPO) and three delta-(DPDPE, DELT, SNC-80) opioid agonists on arterial blood gas after IV administration in awake sheep. None of the mu agonists altered pO2, pCO2 or pH. All three mu agonists decreased pO2 increased pCO2 and decreased pO2, and this effect was not ...

journal_title：Peptides

authors： Szeto HH,Soong Y,Wu D,Olariu N,Kett A,Kim H,Clapp JF

更新日期：1999-01-01 00:00:00

abstract：:Instability and proteolytic degradation limit the delivery options and in vivo efficacy of many therapeutic peptides. We previously generated a thioether stabilized angiotensin-(1-7) analog, cAng-(1-7), which is resistant against proteolytic degradation in the circulation. We here investigated oral and pulmonary deliv...

journal_title：Peptides

authors： de Vries L,Reitzema-Klein CE,Meter-Arkema A,van Dam A,Rink R,Moll GN,Akanbi MH

更新日期：2010-05-01 00:00:00

abstract：:While neuropeptides of the allatostatin family inhibit in vitro production of juvenile hormone, which modulates aspects of development and reproduction in the cockroach, Diploptera punctata, they are susceptible to inactivation by peptidases in the hemolymph, gut, and bound to internal tissues. Patterns of peptidase c...

journal_title：Peptides

authors： Nachman RJ,Garside CS,Tobe SS

更新日期：1999-01-01 00:00:00

abstract：:Double-labeling immunofluorescence of guinea pig tracheobronchial lymph nodes revealed complete coincidence of SP and CGRP immunoreactivities in perivascular nerves and axons of the medullary lymphatic tissue. Additional dynorphin A or cholecystokinin immunoreactivity was seen only in some of the medullary fibers. Ult...

journal_title：Peptides

authors： Kurkowski R,Kummer W,Heym C

更新日期：1990-01-01 00:00:00

abstract：:The effect of synthetic human calcitonin gene-related peptide (hCGRP) on the isolated and electrically driven left atria of rats were investigated. The peptide at concentrations of 3 X 10(-9)-3 X 10(-7) M produced positive inotropic effects on the left atria in a dose-dependent manner. Verapamil (10(-5) M) and adenosi...

journal_title：Peptides

authors： Satoh M,Oku R,Maeda A,Fujii N,Otaka A,Funakoshi S,Yajima H,Takagi H

更新日期：1986-07-01 00:00:00

abstract：:Venoms from cone snails (genus Conus) can be seen as an untapped cocktail of biologically active compounds, being increasingly recognized as an emerging source of peptide-based therapeutics. Cone snails are considered to be specialized predators that have evolved the most sophisticated peptide chemistry and neuropharm...

journal_title：Peptides

authors： Peigneur S,Van Der Haegen A,Möller C,Waelkens E,Diego-García E,Marí F,Naudé R,Tytgat J

更新日期：2013-03-01 00:00:00

abstract：:The role of the D-Trp residues in the sequence of the NK2-selective tachykinin antagonist, MEN 10207 (Asp-Tyr-D-Trp-Val-D-Trp-D-Trp-Arg-NH2). has been examined by replacement of each D-Trp with either the L-isomer or the residue naturally occurring in the same position of neurokinin A(4-10). The biological activity of...

journal_title：Peptides

authors： Rovero P,Astolfi M,Renzetti AR,Patacchini R,Giachetti A,Maggi CA

更新日期：1991-09-01 00:00:00

abstract：:Staphylococcal enterotoxins (SEs) are emetic toxins that cause food poisoning. SEs also function as powerful pyrogenic toxin superantigens that stimulate non-specific T-cell proliferation. Together with the hemolysins, SEs have been largely implicated as virulence factors in multiple infection models. Recent biochemic...

journal_title：Peptides

authors： Vieira-da-Motta O,Ribeiro PD,Dias da Silva W,Medina-Acosta E

更新日期：2001-10-01 00:00:00

abstract：:We previously demonstrated that intracerebroventricular (i.c.v.) administration of the substance P (SP) aminoterminal fragment SP(1-7) attenuates the expression of morphine withdrawal in the male rat. In this study we have used a synthetic analogue of this peptide, i.e. the SP(1-7) amide showing higher binding potency...

journal_title：Peptides

authors： Zhou Q,Carlsson A,Botros M,Fransson R,Sandström A,Gordh T,Hallberg M,Nyberg F

更新日期：2009-12-01 00:00:00

abstract：:The presence of alpha-hANP immunoreactive material in human heart and plasma was investigated with a specific and sensitive radioimmunoassay and immunohistochemical method. It was found that alpha-hANP immunoreactive staining of specific atrial granules was located around the nucleus of atrial cardiocytes. No immunore...

journal_title：Peptides

authors： Tang J,Song DL,Suen MZ,Xie CW,Chang D,Chang JK

更新日期：1986-01-01 00:00:00

abstract：:We studied circulating levels of endothelin-1, catecholamines and nitric oxide after a mental arithmetic test in 14 patients with early ischemic lesions of the extremities due to systemic sclerosis and slightly impaired peripheral vascular flow. The test induced an increase (P<0.01) in blood pressure, heart rate, endo...

journal_title：Peptides

authors： Fontana F,Bernardi P,Lanfranchi G,Conti E,Spampinato S,Di Toro R,Bonafè F,Coccheri S

更新日期：2005-12-01 00:00:00

abstract：:Immunocytochemistry using an antiserum to the C-terminal octapeptide of synenkephalin, proenkephalin(63-70), was performed throughout the rat brain and revealed numerous immunopositive fibers and some cell bodies. The morphology and distribution of synenkephalin immunoreactivity was extremely similar to that of a comm...

journal_title：Peptides

authors： Song DD,Rossier J,Harlan RE

更新日期：1989-11-01 00:00:00

abstract：:Peptides may act through G protein-coupled receptors to influence cardiovascular performance; thus, delineating mechanisms involved in signaling is a molecular-based strategy to influence health. Molecular switches, often represented by conserved motifs, maintain a receptor in an inactive state. However, once the swit...

journal_title：Peptides

authors： Rasmussen M,Leander M,Ons S,Nichols R

更新日期：2015-09-01 00:00:00

abstract：:Angiotensin II (Ang II) is an oligopeptide of the renin-angiotensin system, and Ang II-induced vascular smooth muscle cell (VSMC) proliferation is an important pathophysiological process involved in atherosclerosis; however, the underlying mechanism remains unclear. Orai1 and Stim1 are the main components of store-ope...

journal_title：Peptides

authors： Liu B,Zhang B,Roos CM,Zeng W,Zhang H,Guo R

更新日期：2020-11-01 00:00:00

abstract：:Mastoparan (MP) peptides, distributed in insect venoms, induce a local inflammatory response post envenomation. Most endogenous MPs share common structural elements within a tetradecapeptide sequence that adopts an amphipathic helix whilst traversing biological membranes and when bound to an intracellular protein targ...

journal_title：Peptides

authors： Howl J,Howl L,Jones S

更新日期：2018-03-01 00:00:00