The synthesis of an analogue of the locust CRF-like diuretic peptide, and the biological activities of this and some C-terminal fragments.

abstract：:High performance-gel permeation chromatography (HP-GPC) evaluation of human plasma and serum incubated at 37 degrees C up to 24 h after the addition of long-acting natriuretic peptide (LANP) revealed a 25% decrease in LANP's peak at 2 h followed by an increase in plasma without EDTA at 8 h (p < 0.001). Vessel dilator'...

journal_title：Peptides

authors： Overton RM,Vesely DL

更新日期：1996-01-01 00:00:00

abstract：:Although enterostatin (VPDPR) inhibited morphine-induced analgesia, it had no affinity for mu-opioid receptors. VPDPR administration was reported to elevate serum corticosterone levels. We found that corticosterone exhibited a similar anti-analgesic effect selective for mu-opioid. Furthermore, the anti-analgesic effec...

journal_title：Peptides

authors： Takenaka Y,Nakamura F,Usui H,Lipkowski AW,Toth G,Yoshikawa M

更新日期：2003-05-01 00:00:00

abstract：:In the epileptic brain, hippocampal dentate granule cells become synaptically interconnected through the sprouting of mossy fibers. This new circuitry is expected to facilitate epileptiform discharge. Prolonged seizures induce the long-lasting neoexpression of neuropeptide Y (NPY) in mossy fibers. NPY is released spon...

journal_title：Peptides

authors： Nadler JV,Tu B,Timofeeva O,Jiao Y,Herzog H

更新日期：2007-02-01 00:00:00

abstract：:Bacillus thuringiensis subsp. israelensis (Bti) produces at least four different crystal proteins that are specifically toxic to different mosquito species and that belong to two non-related family of toxins, Cry and Cyt named Cry4Aa, Cry4Ba, Cry11Aa and Cyt1Aa. Cyt1Aa enhances the activity of Cry4Aa, Cry4Ba or Cry11A...

journal_title：Peptides

authors： Cantón PE,Zanicthe Reyes EZ,Ruiz de Escudero I,Bravo A,Soberón M

更新日期：2011-03-01 00:00:00

abstract：:C-type natriuretic peptide (CNP) stimulates endochondrial ossification by activating the transmembrane guanylyl cyclase, natriuretic peptide receptor-B (NPR-B). Recently, a spontaneous autosomal recessive mutation that causes severe dwarfism in mice was identified. The mutant, called long bone abnormality (lbab), cont...

journal_title：Peptides

authors： Yoder AR,Kruse AC,Earhart CA,Ohlendorf DH,Potter LR

更新日期：2008-09-01 00:00:00

abstract：:Dissociated neurointermediate lobe cells (75%) bound [biotinyl-Ser1]corticotropin releasing hormone (bio-CRH) and secreted adrenocorticotropin [ACTH(25-39)] in a reverse hemolytic plaque assay (RHPA). The bio-CRH was rapidly internalized (less than 1 min) in vesicles and scattered vacuoles. Plaque percentages increase...

journal_title：Peptides

authors： Childs GV

更新日期：1990-07-01 00:00:00

abstract：:The insect kinin neuropeptides have been implicated in the regulation of water balance, digestive organ contraction, and energy mobilization in a number of insect species. A previous solution conformation study of an active, restricted-conformation cyclic analog, identified two possible turn conformations as the likel...

journal_title：Peptides

authors： Nachman RJ,Zabrocki J,Olczak J,Williams HJ,Moyna G,Ian Scott A,Coast GM

更新日期：2002-04-01 00:00:00

abstract：:Somatostatin has been proposed as a regulatory peptide of nutrient entry and fuel homeostasis because of its ability to inhibit the release of substances involved in food digestion and metabolism. The aim of the study was to evaluate the somatostatin response to a test meal in type I diabetics at the clinical onset of...

journal_title：Peptides

authors： Uccioli L,Ghirlanda G,Cotroneo P,Bianchini G,Manto A,Solini A,Annese V,Greco AV

更新日期：1986-01-01 00:00:00

abstract：:On attempts to identify toxins showing original profile of activity among K+ channels, we purified Kbot1, a scorpion toxin that blocks Kv1 and SK potassium channels. With 28 amino-acid residues, Kbot1 is the shortest toxin sequenced in Buthus occitanus scorpion. It is linked by three disulfide bridges and its primary ...

journal_title：Peptides

authors： Mahjoubi-Boubaker B,Crest M,Khalifa RB,El Ayeb M,Kharrat R

更新日期：2004-04-01 00:00:00

abstract：:The binding and internalization of a cytotoxic analogue of luteinizing hormone-releasing hormone (LH-RH), T-98 (agonist [D-Lys6]LH-RH linked to glutaryl-2-(hydroxymethyl)anthraquinone), by rat anterior pituitary cells was investigated. Analogue T-98 was bound to pituitary membrane binding sites for LH-RH with a high a...

journal_title：Peptides

authors： Szöke B,Horváth J,Halmos G,Rékási Z,Groot K,Nagy A,Schally AV

更新日期：1994-01-01 00:00:00

abstract：:We have recently characterized bicarinalin as the most abundant peptide from the venom of the ant Tetramorium bicarinatum. This antimicrobial peptide is active against Staphylococcus and Enterobacteriaceae. To further investigate the antimicrobial properties of this cationic and cysteine-free peptide, we have studied ...

journal_title：Peptides

authors： Téné N,Bonnafé E,Berger F,Rifflet A,Guilhaudis L,Ségalas-Milazzo I,Pipy B,Coste A,Leprince J,Treilhou M

更新日期：2016-05-01 00:00:00

abstract：:Gastrin-releasing peptide (GRP) has been implicated in the itch-scratch cycle. We investigated if this gut-brain-skin peptide plays a role in the compulsive, hindleg scratching of the neck of mice by 5'-guanidinonaltrindole (GNTI), the kappa opioid receptor antagonist, and in the antipruritic activity of nalfurafine, ...

journal_title：Peptides

authors： Inan S,Dun NJ,Cowan A

更新日期：2011-02-01 00:00:00

abstract：:A new series of analogues of the potent opiate-like peptides dermorphins (mainly tetra- and pentapeptides) were synthesized in order to better evaluate the structure-activity relationships. Relative potencies were referred to dermorphin (H-Tyr-D-Ala-Phe-Gly-Tyr-Pro-Ser-NH2), the prototype of this class of frog skin pe...

journal_title：Peptides

authors： Melchiorri P,Erspamer GF,Erspamer V,Guglietta A,De Castiglione R,Faoro F,Perseo G,Piani S,Santangelo F

更新日期：1982-09-01 00:00:00

abstract：:The experiments reported here investigate the conditionability, using taste aversion conditioning, of the antagonistic effects of alpha-MSH on the thermoregulatory changes associated with injection of bacterial endotoxin lipopolysaccharide (LPS) in rats. Animals were administered LPS and then given alpha-MSH, as an un...

journal_title：Peptides

authors： Bull DF,Husband AJ,Munro KI,Exton MS,Pfister HP,King MG

更新日期：1994-01-01 00:00:00

abstract：:In the rat small intestine, neurotrophin-3 immunoreactivity was identified in ganglion cells and in processes mostly innervating the mucosa and occasionally the muscle layer and vasculature. The vast majority of neurotrophin-3 immunoreactive neurons contained vasoactive intestinal polypeptide (VIP), but not substance ...

journal_title：Peptides

authors： De Giorgio R,Arakawa J,Wetmore CJ,Sternini C

更新日期：2000-09-01 00:00:00

abstract：:Gastric inhibitory polypeptide (GIP) is a 42-amino acid peptide, belonging to the VIP-secretin-glucagon superfamily, some members of this group are able to regulate adrenocortical function. GIP-receptor mRNA has been detected in the rat adrenal cortex, but investigations on the effect of GIP on steroid-hormone secreti...

journal_title：Peptides

authors： Mazzocchi G,Rebuffat P,Meneghelli V,Malendowicz LK,Tortorella C,Gottardo G,Nussdorfer GG

更新日期：1999-01-01 00:00:00

abstract：:The roles of thyrotropin releasing hormone (TRH) and oxytocin as central regulators of gastric motility were investigated. Picomolar (4 picomoles) quantities of TRH injected into the dorsal motor nucleus of the vagus (DMN) elicited a significant increase in gastric motility while the same quantity of oxytocin elicited...

journal_title：Peptides

authors： Rogers RC,Hermann GE

更新日期：1987-05-01 00:00:00

abstract：:Intestinal levels of immunoreactive neurotensin (iNT) and neuromedin N (iNMN), as well as mRNA for the NT/NMN precursor, were elevated during the suckling period in rats. While transient expression of NT/NMN was observed at 1-5 days of age in the proximal small intestine and colon, NT/NMN levels in the ileum increased...

journal_title：Peptides

authors： Muraki K,Mitra SP,Dobner PR,Carraway RE

更新日期：1993-11-01 00:00:00

abstract：:Sex pheromone biosynthesis in many moth species is controlled by a cerebral neuropeptide, termed pheromone biosynthesis activating neuropeptide (PBAN). PBAN is a 33 amino acid C-terminally amidated neuropeptide that is produced by neuroendocrine cells of the subesophageal ganglion (SEG). Studies of the regulation of s...

journal_title：Peptides

authors： Altstein M

更新日期：2004-09-01 00:00:00

abstract：:CRF injected into the third cerebral ventricle (0.5-2.5 micrograms) caused dose-related reductions in fever induced in rabbits by IV administration of leukocytic pyrogen. Control injections of CRF when the same animals were afebrile did not alter normal body temperature. Intravenous injections of 5 and 20 micrograms C...

journal_title：Peptides

authors： Bernardini GL,Richards DB,Lipton JM

更新日期：1984-01-01 00:00:00

abstract：:Atriopeptins are circulating peptide hormones which are secreted by atrial tissue and act at the kidney. Because the atriopeptins survive passage through the pulmonary circulation, they also may be involved in the modulation of airway or pulmonary vascular smooth muscle tone. Using in vitro organ bath techniques, atri...

journal_title：Peptides

authors： O'Donnell M,Garippa R,Welton AF

更新日期：1985-07-01 00:00:00

abstract：:We recently reported the direct inhibitory effect of adrenomedullin on caecal circular smooth muscle cells via cAMP system. This study was designed to determine whether the structurally related peptides to adrenomedullin (i.e.; calcitonin gene-related peptide (CGRP), calcitonin, and amylin) can inhibit the cholecystok...

journal_title：Peptides

authors： Ochiai T,Chijiiwa Y,Motomura Y,Yasuda O,Harada N,Nawata H

更新日期：2001-06-01 00:00:00

abstract：:The aim was to study the effects of C-type natriuretic peptide (CNP) on mean arterial pressure (MAP) and the cardiovascular nitric oxide (NO) system in spontaneously hypertensive rats (SHR), and to investigate the signaling pathways involved in this interaction. SHR and WKY rats were infused with saline or CNP. MAP an...

journal_title：Peptides

authors： Caniffi C,Elesgaray R,Gironacci M,Arranz C,Costa MA

更新日期：2010-07-01 00:00:00

abstract：:In the crayfish Astacus leptodactylus, as in several crustacean species, the crustacean hyperglycemic hormone is present as two isoforms differing by the chirality of the third residue, a phenylalanine. In the present work, isoforms synthesized full length by solid-phase peptide synthesis have been purified, refolded,...

journal_title：Peptides

authors： Lebaupain F,Boscameric M,Pilet E,Soyez D,Kamech N

更新日期：2012-03-01 00:00:00

abstract：:Urotensin II (U-II) is a vasoactive peptide with many potent effects in the cardiorenovascular system. U-II activates a G-protein-coupled receptor termed UT. UT and U-II are highly expressed in the cardiovascular and renal system. Patients with various cardiovascular diseases show high U-II plasma levels. It was demon...

journal_title：Peptides

authors： Tölle M,van der Giet M

更新日期：2008-05-01 00:00:00

abstract：:Antibiotic therapy for methicillin-resistant Staphylococcus aureus (MRSA) infections is becoming more difficult in hospitals and communities because of strong biofilm-forming properties and multidrug resistance. Biofilm-associated MRSA is not affected by therapeutically achievable concentrations of antibiotics. Theref...

journal_title：Peptides

authors： Dosler S,Mataraci E

更新日期：2013-11-01 00:00:00

abstract：:The amino acid sequence of the vasoactive intestinal polypeptide (VIP) is well conserved between species. Thus, all mammalian VIPs isolated so far, except that of the guinea pig, have the same amino acid sequence. This study describes the isolation and primary structure of sheep brain VIP. The purification was followe...

journal_title：Peptides

authors： Gafvelin G

更新日期：1990-07-01 00:00:00

abstract：:Obestatin is a recently discovered peptide hormone that appears to be involved in reducing food intake, gut motility and body weight. Obestatin is a product of the preproghrelin gene and appears to oppose several physiological actions of ghrelin. This study investigated the acute effects of obestatin (1-23) and the tr...

journal_title：Peptides

authors： Green BD,Irwin N,Flatt PR

更新日期：2007-05-01 00:00:00

abstract：:Alzheimer's disease is one of the most common dementia among elderly worldwide. There is no therapeutic drugs until now to treat effectively this disease. One main reason is due to the poorly understood mechanism of Aβ peptide aggregation, which plays a crucial role in the development of Alzheimer's disease. It remain...

journal_title：Peptides

authors： Tran L,Ha-Duong T

更新日期：2015-07-01 00:00:00

abstract：:Neurotensin (NT) is a tridecapeptide (less than Glu-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Tyr-Ile-Leu-OH). It has been suggested that the naturally occurring neurotensin in (Gln4)-NT and that it can be hydrolysed to (Glu4)-NT during extraction. The aim of the present study was to determine whether the neurotensin found ...

journal_title：Peptides

authors： Theodorsson-Norheim E

更新日期：1983-07-01 00:00:00