Abstract：
:The presence of alpha-hANP immunoreactive material in human heart and plasma was investigated with a specific and sensitive radioimmunoassay and immunohistochemical method. It was found that alpha-hANP immunoreactive staining of specific atrial granules was located around the nucleus of atrial cardiocytes. No immunoreactive staining was found in the ventricle. The content of immunoreactive hANP was 0.5 pmol/mg protein in the atria and 0.11 +/- 0.01 pmol/ml in the plasma of 26 normal volunteers. In 16 patients with congestive heart failure and 26 patients with essential hypertension, the plasma level of immunoreactive alpha-hANP was significantly lower than that in normal humans. The above evidence indicate that alpha-hANP is a putative hormone secreted by human atrium. A relative shortage of alpha-hANP in the circulatory system may be involved in the mechanism of heart failure and hypertension.
journal_name
Peptidesjournal_title
Peptidesauthors
Tang J,Song DL,Suen MZ,Xie CW,Chang D,Chang JKdoi
10.1016/0196-9781(86)90057-4subject
Has Abstractpub_date
1986-01-01 00:00:00pages
33-7issue
1eissn
0196-9781issn
1873-5169pii
0196-9781(86)90057-4journal_volume
7pub_type
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