Distribution of two distinct messenger ribonucleic acids encoding gastrin-releasing peptide in rat brain.

abstract：:The effect of synthetic human calcitonin gene-related peptide (hCGRP) on the isolated and electrically driven left atria of rats were investigated. The peptide at concentrations of 3 X 10(-9)-3 X 10(-7) M produced positive inotropic effects on the left atria in a dose-dependent manner. Verapamil (10(-5) M) and adenosi...

journal_title：Peptides

authors： Satoh M,Oku R,Maeda A,Fujii N,Otaka A,Funakoshi S,Yajima H,Takagi H

更新日期：1986-07-01 00:00:00

abstract：:A novel peptide hormone, atrial natriuretic factor (ANF), was recently isolated and characterized in mammalian atria. This hormone has potent natriuretic diuretic and vasorelaxant activities. Since ANF bioactivity was initially found in atria but not in ventricles, it was assumed that the ANF gene is specifically expr...

journal_title：Peptides

authors： Nemer M,Lavigne JP,Drouin J,Thibault G,Gannon M,Antakly T

更新日期：1986-11-01 00:00:00

abstract：:As a novel vasoactive peptide, plasma coupling factor 6 (CF6) was shown to be elevated in patients with diabetes mellitus, yet the mechanism involved is unknown. We studied CF6 protein release and its potential mechanism in human umbilical vein endothelial cells (HUVECs) incubated with high glucose levels. High glucos...

journal_title：Peptides

authors： Li X,Xing S,Zhang L,Xing Q,Yan S,Dai H,You S,Pang Y,Tang C

更新日期：2007-03-01 00:00:00

abstract：:The secretin receptor is a member of a large family of G-protein-coupled receptors that recognize polypeptide hormone and/or neuropeptides. Charged, conserved residues might play a key role in their function, either by interacting with the ligand or by stabilizing the receptor structure. Of the four charged amino acid...

journal_title：Peptides

authors： Di Paolo E,Vilardaga JP,Petry H,Moguilevsky N,Bollen A,Robberecht P,Waelbroeck M

更新日期：1999-01-01 00:00:00

abstract：:The objective of this study was to investigate absorption enhancing approaches for systemic delivery of methionine enkephalin via the nose. Absorption promotion of methionine enkephalin in the presence of protease inhibitors (bestatin, puromycin) and absorption enhancers (glycocholate, dimethyl-beta-cyclodextrin) were...

journal_title：Peptides

authors： Agu RU,Vu Dang H,Jorissen M,Kinget R,Verbeke N

更新日期：2004-04-01 00:00:00

abstract：:The detection of the prodynorphin gene in anuran amphibians and lungfishes may indicate that this gene arose as a result of the duplication of the proenkephalin gene early during the divergence of the Sarcopterygii, or that this gene may predate the divergence of the ray-finned fish and the lobe-finned fish. The cloni...

journal_title：Peptides

authors： Alrubaian J,Lecaude S,Barba J,Szynskie L,Jacobs N,Bauer D,Brown C,Kaminer I,Bagrosky B,Dores RM

更新日期：2006-04-01 00:00:00

abstract：:Effects of pentobarbital, chlordiazepoxide and ethanol were studied alone and in combination with thyrotropin-releasing hormone (TRH), IM, on punished behavior. Key-peck responses of pigeons were maintained by food presentation under a fixed-interval 3-min schedule in which every 30th response produced shock. Moderate...

journal_title：Peptides

authors： Witkin JM,Sickle J,Barrett JE

更新日期：1984-07-01 00:00:00

abstract：:Somatostatin has been proposed as a regulatory peptide of nutrient entry and fuel homeostasis because of its ability to inhibit the release of substances involved in food digestion and metabolism. The aim of the study was to evaluate the somatostatin response to a test meal in type I diabetics at the clinical onset of...

journal_title：Peptides

authors： Uccioli L,Ghirlanda G,Cotroneo P,Bianchini G,Manto A,Solini A,Annese V,Greco AV

更新日期：1986-01-01 00:00:00

abstract：:The effects of acute and subchronic administration of chlordiazepoxide (CDZ) on [3H][3-methyl-histidyl2]thyrotropin-releasing hormone binding to thyrotropin-releasing hormone (TRH) receptors in membrane preparations from various regions of rat brain were examined. Acute administration of CDZ (50 mg/kg x 3 within 24 h)...

journal_title：Peptides

authors： Shimoda K,Mason GA,Walker CH,Garbutt JC,Prange AJ Jr

更新日期：1991-01-01 00:00:00

abstract：:Antimicrobial peptides (AMP) have been widely described in several organisms from different kingdoms. We recently designed and evaluated a synthetic version of an AMP isolated and characterized from Argopecten purpuratus hemocytes. This study describes the generation of a chimaeric gene encoding for Ap-S, the use of t...

journal_title：Peptides

authors： Tapia E,Montes C,Rebufel P,Paradela A,Prieto H,Arenas G

更新日期：2011-09-01 00:00:00

abstract：:The localization of endozepine-like immunoreactivity in the brain of the frog Rana ridibunda was investigated by indirect immunofluorescence, using an antiserum against synthetic rat octadecaneuropeptide (ODN). A specific immunoreaction was detected in ependymal cells lining the ventricular system of the brain and in ...

journal_title：Peptides

authors： Malagon M,Vaudry H,Vallarino M,Gracia-Navarro F,Tonon MC

更新日期：1992-01-01 00:00:00

abstract：:The amidated beta-casomorphin morphiceptin Tyr-Pro-Phe-Pro-NH2 is an opioid peptide isolated from bovine milk beta-casein digests whose physiological significance remains unclear. Opiates are known to modify intestinal electrolyte transport by acting on receptors located on the serosal side of the intestine. The aim o...

journal_title：Peptides

authors： Mahe S,Tome D,Dumontier AM,Desjeux JF

更新日期：1989-01-01 00:00:00

abstract：:The ability of acute exercise to stimulate appetite and food intake depends on intensity, duration, and agouti-related protein (AGRP) levels. Fasting, as well as any negative energy balance, has been reported to increase AGRP expression in the arcuate nucleus (ARC) of the hypothalamus and other extra-hypothalamic tiss...

journal_title：Peptides

authors： Ghanbari-Niaki A,Nabatchian S,Hedayati M

更新日期：2007-05-01 00:00:00

abstract：:We have recently characterized bicarinalin as the most abundant peptide from the venom of the ant Tetramorium bicarinatum. This antimicrobial peptide is active against Staphylococcus and Enterobacteriaceae. To further investigate the antimicrobial properties of this cationic and cysteine-free peptide, we have studied ...

journal_title：Peptides

authors： Téné N,Bonnafé E,Berger F,Rifflet A,Guilhaudis L,Ségalas-Milazzo I,Pipy B,Coste A,Leprince J,Treilhou M

更新日期：2016-05-01 00:00:00

abstract：:As a class of peptides with 10 cysteine residues (-C-CC-C-CC-C-C-C-C-), D-superfamily conotoxins (D-conotoxins) can specifically act on nicotinic acetylcholine receptors (nAChRs). According to the conserved signal peptides of D-conotoxins, seven D-conotoxin precursor sequences with a previously undescribed Cys arrange...

journal_title：Peptides

authors： Lu J,Zhang K,Wang S,Sun T,Yu S,Dai Q,Liu Z

更新日期：2017-08-01 00:00:00

abstract：:VIP receptors on blood mononuclear leucocytes and plasma VIP concentrations were studied during a ranger training course lasting for five days with almost continuous physical activity, and energy deficiency. The maximum binding capacity (Bmax) for the high affinity receptor increased (p less than 0.0005) from 0.71 (SE...

journal_title：Peptides

authors： Wiik P,Opstad PK,Knardahl S,Bøyum A

更新日期：1988-01-01 00:00:00

abstract：:Activation of natriuretic peptide receptor-A (NPRA) produces the second messenger cGMP, which plays a pivotal role in maintaining blood pressure and cardiovascular homeostasis. In the present study, we have examined the role of trans-acting factor Ets-1 in transcriptional regulation of Npr1 gene (coding for NPRA). Usi...

journal_title：Peptides

authors： Kumar P,Arise KK,Pandey KN

更新日期：2006-07-01 00:00:00

abstract：:The effects of iontophoretically applied human pancreatic growth hormone-releasing factor (hpGRF), peptide histidine isoleucine (PHI-27), and somatostatin (SS) on the extracellular activity of single cells in the hypothalamus, thalamus, and cortex of the rat brain were studied in urethane-anesthetized, male rats. Neur...

journal_title：Peptides

authors： Twery MJ,Moss RL

更新日期：1985-07-01 00:00:00

abstract：:Concentrations of immunoreactive galanin were compared in eight gross brain regions of ovariectomized female rats treated with either estradiol, estradiol + progesterone, estradiol + norethisterone, or placebo. Higher concentrations with estradiol treatment compared with placebo were found in the pituitary (357%), fro...

journal_title：Peptides

authors： Rugarn O,Theodorsson A,Hammar M,Theodorsson E

更新日期：1999-01-01 00:00:00

abstract：:Irisin is a novel myokine and adipokine that has gained much attention recently due to its mechanisms of action. Irisin is secreted following proteolytic cleavage of its precursor fibronectin type III domain containing 5 (FNDC5). Following its release, irisin exerts its major action by increasing the expression of mit...

journal_title：Peptides

authors： Mahgoub MO,D'Souza C,Al Darmaki RSMH,Baniyas MMYH,Adeghate E

更新日期：2018-06-01 00:00:00

abstract：:The effect of EGF on the incorporation of [3H]TdR into DNA (DNA synthesis) was determined in the esophagus, liver, pancreas, and kidney in mice standardized to 12 hours (hr) of light alternating with 12 hr of darkness. A question asked was whether intraperitoneally administered EGF could alter the circadian patterns o...

journal_title：Peptides

authors： Scheving LA,Tsai TH,Scheving LE,Hoke WS

更新日期：1987-03-01 00:00:00

abstract：:Staphylococcal enterotoxins (SEs) are emetic toxins that cause food poisoning. SEs also function as powerful pyrogenic toxin superantigens that stimulate non-specific T-cell proliferation. Together with the hemolysins, SEs have been largely implicated as virulence factors in multiple infection models. Recent biochemic...

journal_title：Peptides

authors： Vieira-da-Motta O,Ribeiro PD,Dias da Silva W,Medina-Acosta E

更新日期：2001-10-01 00:00:00

abstract：:During a systemic search for peptides that possess the C-terminal amide structure, a novel heptapeptide with isoleucine amide was isolated from bovine serum by sequential steps of reversed phase HPLC. Microsequence and amino acid analyses revealed the structure: Asp-Thr-His-Lys-Ser-Glu-Ile-NH2. Since this peptide has ...

journal_title：Peptides

authors： Takamatsu K,Tatemoto K

更新日期：1991-03-01 00:00:00

abstract：:The levels of rat plasma beta-endorphin-like immunoreactivity following a 30 min exposure to (1) an unfamiliar operant chamber, (2) an unfamiliar operant chamber providing a VI-5 second schedule of 3 mA, 1 sec footshocks, or (3) a familiar chamber providing no shocks, but previously paired with unavoidable shocks were...

journal_title：Peptides

authors： Scallet AC

更新日期：1982-03-01 00:00:00

abstract：:A putative genome duplication event within the Silurana lineage has given rise to the tetraploid Cameroon clawed frog Silurana epitropicalis (Fischberg, Colombelli, and Picard, 1982). Peptidomic analysis of norepinephrine-stimulated skin secretions of S. epitropicalis led to identification of 10 peptides with varying ...

journal_title：Peptides

authors： Conlon JM,Mechkarska M,Prajeep M,Sonnevend A,Coquet L,Leprince J,Jouenne T,Vaudry H,King JD

更新日期：2012-09-01 00:00:00

abstract：:Host-defense peptides secreted by epithelial cells exhibit cytotoxic and immunoregulatory effects in order to protect the organism against invading microorganisms. Antimicrobial peptides derived from frog skin display both immunostimulatory and immunosuppressive actions as demonstrated by in vitro cytokine production ...

journal_title：Peptides

authors： Pantic JM,Radosavljevic GD,Jovanovic IP,Arsenijevic NN,Conlon JM,Lukic ML

更新日期：2015-09-01 00:00:00

abstract：:The use of protein A- and IgG-conjugated colloidal gold staining methods for the immuno-localisation of peptide hormones and neurotransmitters at light- and electron microscope level are described and discussed. Bright-field and dark-ground illumination modes have been used to visualise the gold-labelled antigenic sit...

journal_title：Peptides

authors： Varndell IM,Tapia FJ,Probert L,Buchan AM,Gu J,De Mey J,Bloom SR,Polak JM

更新日期：1982-05-01 00:00:00

abstract：:Kiss1 mRNA and its corresponding peptide products, kisspeptins, are expressed in two restricted brain areas of rodents, the anteroventral periventricular nucleus (AVPV) and the arcuate nucleus (ARC). The concentration of mature kisspeptins may not directly correlate with Kiss1 mRNA levels, because mRNA translation and...

journal_title：Peptides

authors： Overgaard A,Tena-Sempere M,Franceschini I,Desroziers E,Simonneaux V,Mikkelsen JD

更新日期：2013-07-01 00:00:00

abstract：:We labeled substance P (SP), neurokinin A (NKA), and [Lys0]gastrin-releasing peptide-27 (GRP) with cyanine 3.18 (cy3). Cy3-peptides purified by HPLC were fully active, determined by [Ca2+]i mobilization. Binding was specific because it was abolished by unlabeled peptides and receptor antagonists. Transfected cells yie...

journal_title：Peptides

authors： Bunnett NW,Dazin PF,Payan DG,Grady EF

更新日期：1995-01-01 00:00:00

abstract：:Endokinins are novel tachykinins encoded on the human TAC4 and consist of Endokinin A (EKA), B (EKB), C (EKC) and D (EKD). To date, the function of Endokinins in pain processing was not fully understood. Therefore the aim of this study was to investigate the effects of Endokinin A/B (EKA/B, the common C-terminal decap...

journal_title：Peptides

authors： Yang Y,Dong S

更新日期：2010-01-01 00:00:00