Abstract:
:To determine whether centrally released vasopressin influences thirst, observations of osmotic thirst threshold, osmotic load excretion and postloading restitution of plasma osmolality were made in dogs in control experiments and during infusion of AVP antagonists into the third ventricle. Significant elevation of osmotic thirst threshold was elicited by infusion of d(CH2)5AVP at a rate of 0.2-2.0 micrograms.min-1 and of d(Et2)AVP at a rate of 0.3 micrograms.min-1 (V1 antagonists, weak V2 agonists) as well as by administration of d(CH2)5[D-Ile2,Abu4]AVP at a rate of 0.4 micrograms.min-1 (potent V2 antagonist, weak V1 antagonist). Administration of d(CH2)5AVP at a rate of 2.0 micrograms.min-1 was associated with a significant suppression of the postloading water intake and osmotic load excretion and with a delay in restitution of plasma osmolality. These findings indicate that centrally released vasopressin may participate in the control of thirst.
journal_name
Peptidesjournal_title
Peptidesauthors
Szczepanska-Sadowska E,Sobocinska J,Kozłowski Sdoi
10.1016/0196-9781(87)90128-8subject
Has Abstractpub_date
1987-11-01 00:00:00pages
1003-9issue
6eissn
0196-9781issn
1873-5169pii
0196-9781(87)90128-8journal_volume
8pub_type
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