Molecular identification of SGPP-5, a novel pacifastin-like peptide precursor in the desert locust.

abstract：:The presence of alpha-hANP immunoreactive material in human heart and plasma was investigated with a specific and sensitive radioimmunoassay and immunohistochemical method. It was found that alpha-hANP immunoreactive staining of specific atrial granules was located around the nucleus of atrial cardiocytes. No immunore...

journal_title：Peptides

authors： Tang J,Song DL,Suen MZ,Xie CW,Chang D,Chang JK

更新日期：1986-01-01 00:00:00

abstract：:ACTH-(1-24) inhibits the in vitro binding of the muscarinic antagonist [3H]QNB to membranes from rat brain. The magnitude of inhibition is dependent on the concentration of ACTH-(1-24). Kinetic analysis indicates a pure competitive inhibition which is suggestive of a reversible interaction of ACTH with muscarinic rece...

journal_title：Peptides

authors： Tonnaer JA,Van Vugt M,De Graaf JS

更新日期：1986-05-01 00:00:00

abstract：:The neuropharmacological basis for d-amphetamine induced paradoxical behavioral thermoregulation remains unclear. This study examined thermoregulatory behavior of rats in a runway device that housed a heat source at one end and in which locomotion along the length of the runway could be observed. Sprague Dawley rats w...

journal_title：Peptides

authors： Yehuda S,Sheleff P

更新日期：1985-03-01 00:00:00

abstract：:Purified mast cell carboxypeptidase cleaved the C-terminal leucines from Leu5-enkephalin (Leu-ENK), neurotensin (NT), and kinetensin (KT), with Km values of 36, 16, and 15 microM, and kcat values of 44, 51, and 53 s-1, respectively. To better predict potential in vivo hydrolysis products generated by mast cell proteas...

journal_title：Peptides

authors： Goldstein SM,Leong J,Bunnett NW

更新日期：1991-09-01 00:00:00

abstract：:To identify male-specific genes that could be involved in male development, we screened a subtracted male reproductive tract library and isolated a novel gene named Mar-Mrr (M. rosenbergii male reproduction-related gene). The Mar-Mrr cDNA sequence consists of 683 nucleotides with a 333 nucleotide open reading frame, e...

journal_title：Peptides

authors： Cao JX,Yin GL,Yang WJ

更新日期：2006-04-01 00:00:00

abstract：:Cardiac hypertrophy, an adaptive process to an increased hemodynamic overload, includes not only an increase in cell size but also qualitative changes in constituent proteins. Although swelling-activated chloride channels (I(Cl,swell)) chronically activate in hypertrophied atrial myocytes, the role of I(Cl,swell) in r...

journal_title：Peptides

authors： Bai GY,Yuan K,Park WH,Kim SZ,Kim SH

更新日期：2008-09-01 00:00:00

abstract：:Degradation of Boc CCK7 (Boc Tyr1 (SO3H)-Met2-Gly3-Trp4-Met5-Asp6-Phe7-NH2), a fully active analog of CCK8, by purified rabbit kidney neutral metalloendopeptidase (enkephalinase) was studied as a basis for the rational design of potent peptidases-resistant analogs of cholecystokinin. Characterization of the metabolite...

journal_title：Peptides

authors： Durieux C,Charpentier B,Fellion E,Gacel G,Pelaprat D,Roques BP

更新日期：1985-05-01 00:00:00

abstract：:Tardive dyskinesia, a clinical syndrome, is one of the major side effects of protracted treatment with neuroleptics in schizophrenic patients. Functional supersensitivity of striatal dopamine receptors is believed to contribute to the pathogenesis of schizophrenia and tardive dyskinesia. In a rodent model of neurolept...

journal_title：Peptides

authors： Rajakumar G,Naas F,Johnson RL,Chiu S,Yu KL,Mishra RK

更新日期：1987-09-01 00:00:00

abstract：:Synthetic peptides containing a phosphorylation site for protein kinase CK2 were used to investigate their binding properties to other peptides/proteins. The aim of this work was to find an efficient procedure to search for these peptide/protein ligands. The goal was successfully achieved through screening of random p...

journal_title：Peptides

authors： Cardellini E,Felici F,Gianfranceschi GL

更新日期：2004-02-01 00:00:00

abstract：:Substance P (SP) has been implicated in the pathophysiology of ulcerative colitis (UC) and it has been suggested that blocking of its effect would be advantageous in this disease. Eosinophils have also been implicated in the pathophysiology of UC. In the present study, specimens from the sigmoid colon of UC patients w...

journal_title：Peptides

authors： Jönsson M,Norrgård O,Forsgren S

更新日期：2005-05-01 00:00:00

abstract：:Somatostatin has been proposed as a regulatory peptide of nutrient entry and fuel homeostasis because of its ability to inhibit the release of substances involved in food digestion and metabolism. The aim of the study was to evaluate the somatostatin response to a test meal in type I diabetics at the clinical onset of...

journal_title：Peptides

authors： Uccioli L,Ghirlanda G,Cotroneo P,Bianchini G,Manto A,Solini A,Annese V,Greco AV

更新日期：1986-01-01 00:00:00

abstract：:The analysis of the spectrum of circular dichroism (CD) of methionine-oxidized bovine parathyroid hormone peptide, bPTH(1-34) revealed that approximately 43% of the orderly conformation (alpha-helix and beta-sheet) was converted into random coil structure. This peptide failed to elicit any hypotensive response in rats...

journal_title：Peptides

authors： Hong BS,Yang MC,Liang JN,Pang PK

更新日期：1986-11-01 00:00:00

abstract：:A putative genome duplication event within the Silurana lineage has given rise to the tetraploid Cameroon clawed frog Silurana epitropicalis (Fischberg, Colombelli, and Picard, 1982). Peptidomic analysis of norepinephrine-stimulated skin secretions of S. epitropicalis led to identification of 10 peptides with varying ...

journal_title：Peptides

authors： Conlon JM,Mechkarska M,Prajeep M,Sonnevend A,Coquet L,Leprince J,Jouenne T,Vaudry H,King JD

更新日期：2012-09-01 00:00:00

abstract：:The cDNAs encoding the preprohormones of the regulatory peptides cholecystokinin (CCK) and the related gastrin have been identified in a number of vertebrate species. However, from birds only chicken preprogastrin is known. In the present study preproCCK cDNA was identified in two species of birds, ostrich and chicken...

journal_title：Peptides

authors： Jønson L,Schoeman N,Saayman H,Naudé R,Jensen H,Johnsen AH

更新日期：2000-09-01 00:00:00

abstract：:Previous corticotropin releasing factor 1 (CRF1) receptor characterization has been performed using radiolabeled agonists, which bind predominantly the receptor-G-protein complex. The pharmacological profile of other receptor states, and their abundance, remain poorly characterized. Here we investigated the affinity s...

journal_title：Peptides

authors： Hoare SR,Sullivan SK,Pahuja A,Ling N,Crowe PD,Grigoriadis DE

更新日期：2003-12-01 00:00:00

abstract：:The discovery of several adipokines with diverse activities and their involvement in regulation of various pathophysiological functions of human body has challenged the researchers. In the family of adipokine, chemerin is a novel and unique addition. Ever since the first report on chemerin as a chemo-attractant protei...

journal_title：Peptides

authors： Fatima SS,Rehman R,Baig M,Khan TA

更新日期：2014-12-01 00:00:00

abstract：OBJECTIVES:The aim of the present studywas to examine the question of whether the atrial natriuretic peptide (ANP) system is altered by endothelial nitric-oxide synthase (eNOS). METHODS:Male eNOS-deficient mice (eNOS-/-) and wild type control mice (eNOS+/+, C57B1/6J) were used. Blood pressure was measured in anestheti...

journal_title：Peptides

authors： Yuan K,Kim SY,Oh YB,Yu J,Shah A,Park BH,Kim SH

更新日期：2010-07-01 00:00:00

abstract：:As an attempt to approach the pathogenesis of peptic ulcer disease, antral gastrin and somatostatin concentrations were studied in normal subjects, patients with duodenal ulcer and gastric ulcer. In the patients with peptic ulcer, antral somatostatin concentrations were significantly lower than those in normal subject...

journal_title：Peptides

authors： Sumii K,Fukushima T,Hirata K,Matsumoto Y,Sanuki E,Tsumaru S,Sumioka M,Miyoshi A,Miyachi Y

更新日期：1981-01-01 00:00:00

abstract：:Broad-spectrum antiviral drugs are urgently needed to treat individuals infected with new and re-emerging viruses, or with viruses that have developed resistance to antiviral therapies. Mammalian natural host defense peptides (mNHP) are short, usually cationic, peptides that have direct antimicrobial activity, and whi...

journal_title：Peptides

authors： Sample CJ,Hudak KE,Barefoot BE,Koci MD,Wanyonyi MS,Abraham S,Staats HF,Ramsburg EA

更新日期：2013-10-01 00:00:00

abstract：:Instability and proteolytic degradation limit the delivery options and in vivo efficacy of many therapeutic peptides. We previously generated a thioether stabilized angiotensin-(1-7) analog, cAng-(1-7), which is resistant against proteolytic degradation in the circulation. We here investigated oral and pulmonary deliv...

journal_title：Peptides

authors： de Vries L,Reitzema-Klein CE,Meter-Arkema A,van Dam A,Rink R,Moll GN,Akanbi MH

更新日期：2010-05-01 00:00:00

abstract：:This study was designed to test the possibility that antimicrobial peptides could be derived from the genomic sequences of phage lysins. Using two lysins (D3 and PhiKZ) we selected and produced two putative peptides (X and Z, respectively) believed to possess antimicrobial properties based on their physicochemical cha...

journal_title：Peptides

authors： Rotem S,Radzishevsky I,Inouye RT,Samore M,Mor A

更新日期：2006-01-01 00:00:00

abstract：:The extractability of neurotensin (NT) from porcine ileal mucosa was studied by comparison of eight extraction procedures. Tissue content of neurotensin-like immunoreactivity was quantitated and characterized by sequence-specific radioimmunoassays and gel filtration chromatography. Homogenization prior to boiling in e...

journal_title：Peptides

authors： Yamashita Y,Holst Pedersen J,Stadil F

更新日期：1987-07-01 00:00:00

abstract：:For clinical use, it is essential to develop potent endomorphin (EM) analogs with reduced antinociceptive tolerance. In the present study, the antinociceptive activities and tolerance development of four potent EM-1 analogs with C-terminal oligoarginine-conjugation was evaluated and compared in the radiant heat paw wi...

journal_title：Peptides

authors： Yuan BY,Liu WZ,Wang XF,Zhang YZ,Yang DJ,Wang CL

更新日期：2018-08-01 00:00:00

abstract：:Parathyroid hormone (PTH) has been shown to have actions within the brain, suggesting the presence of central PTH receptors. This possibility was examined by determining the binding of 125I-labeled [Nle8,18,Tyr34]bovine PTH to the plasma membranes of rat and rabbit brains. Specific binding of the tracer to membranes o...

journal_title：Peptides

authors： Harvey S,Hayer S

更新日期：1993-11-01 00:00:00

abstract：:Peptides may act through G protein-coupled receptors to influence cardiovascular performance; thus, delineating mechanisms involved in signaling is a molecular-based strategy to influence health. Molecular switches, often represented by conserved motifs, maintain a receptor in an inactive state. However, once the swit...

journal_title：Peptides

authors： Rasmussen M,Leander M,Ons S,Nichols R

更新日期：2015-09-01 00:00:00

abstract：:Neural input to distinct and separate populations of CRF-immunoreactive (ir) neurons in rat forebrain was investigated. The relationship of opiocortin and/or catecholamine fibers to different groups of CRF-containing neurons was elucidated using single and dual labeling immunocytochemical procedures. Antibodies to CRF...

journal_title：Peptides

authors： Hornby PJ,Piekut DT

更新日期：1989-11-01 00:00:00

abstract：:Glucagon-like-peptide-1 (GLP-1) is a proglucagon-derived peptide expressed in the intestinal enteroendocrine-L cells and released after meal ingestion. GLP-1 reduces postprandial glycemia not only by its hormonal effects, but also by its inhibitory effects on gastrointestinal motility. Recently, we showed that GLP-1 a...

journal_title：Peptides

authors： Rotondo A,Amato A,Lentini L,Baldassano S,Mulè F

更新日期：2011-01-01 00:00:00

abstract：:The melanocortin 4 receptor (MC4R) plays an essential role in weight regulation. Recently we could show that the MC4R is able to form receptor dimers. In the present study we investigated the role of extracellular cysteine residues and the structure of the third extracellular loop for receptor dimerization. None of th...

journal_title：Peptides

authors： Elsner A,Tarnow P,Schaefer M,Ambrugger P,Krude H,Grüters A,Biebermann H

更新日期：2006-02-01 00:00:00

abstract：:The neuropeptide oxytocin (OXT) contributes to the regulation of diverse cognitive and physiological functions including nociception. Indeed, OXT has been reported to be analgesic when administered directly into the brain, the spinal cord, or systemically. Although many authors have reported the analgesic effects of O...

journal_title：Peptides

authors： Russo R,D'Agostino G,Mattace Raso G,Avagliano C,Cristiano C,Meli R,Calignano A

更新日期：2012-11-01 00:00:00

abstract：:Although renin, the rate-limiting enzyme of the renin-angiotensin system (RAS), was first discovered by Robert Tigerstedt and Bergman more than a century ago, the research on the RAS still remains stronger than ever. The RAS, once considered to be an endocrine system, is now widely recognized as dual (circulating and ...

journal_title：Peptides

authors： Zhuo JL,Li XC

更新日期：2011-07-01 00:00:00