Abstract:
:Tardive dyskinesia, a clinical syndrome, is one of the major side effects of protracted treatment with neuroleptics in schizophrenic patients. Functional supersensitivity of striatal dopamine receptors is believed to contribute to the pathogenesis of schizophrenia and tardive dyskinesia. In a rodent model of neuroleptic-induced dopamine receptor supersensitivity, we investigated the efficacy of structurally modified analogues of PLG to down-regulate the striatal dopamine receptor supersensitivity as determined by alterations in [3H]spiroperidol binding to striatal membranes in vitro. The PLG analogue, L-prolyl-L-leucyl-(+)-thiazolidine-2-carboxamide-HCl, when given at the dose of 10 mg/kg IP for 5 days prior to haloperidol (3 mg/kg IP 21 days) significantly prevented the up-regulation of striatal dopamine receptor supersensitivity, thus demonstrating a prophylactic effect. Two other analogues, L-prolyl-L-leucyl-5-aminomethyltetrazole and L-prolyl-L-leucyl-glycine-dimethylamide at a dose of 10 mg/kg IP when given concurrently with haloperidol for 21 days, suppressed the development of dopamine receptor supersensitivity. None of the analogues tested in the post-haloperidol session reversed the haloperidol-induced increase in the density of striatal dopamine receptors. Active PLG analogues hold promise as potential therapeutic agents for the amelioration of tardive dyskinesia.
journal_name
Peptidesjournal_title
Peptidesauthors
Rajakumar G,Naas F,Johnson RL,Chiu S,Yu KL,Mishra RKdoi
10.1016/0196-9781(87)90072-6subject
Has Abstractpub_date
1987-09-01 00:00:00pages
855-61issue
5eissn
0196-9781issn
1873-5169pii
0196-9781(87)90072-6journal_volume
8pub_type
杂志文章相关文献
PEPTIDES文献大全abstract::Antimicrobial peptides (AMP) have been widely described in several organisms from different kingdoms. We recently designed and evaluated a synthetic version of an AMP isolated and characterized from Argopecten purpuratus hemocytes. This study describes the generation of a chimaeric gene encoding for Ap-S, the use of t...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2011.07.007
更新日期:2011-09-01 00:00:00
abstract::Endothelial neutral endopeptidase (EC 3.4.24.11, NEP) contributes to the inactivation of vasoactive and inflammatory peptides such as f-Met-Leu-Phe, substance P, atrial natriuretic peptide, and bradykinin. The aim of the present study was to investigate the cellular regulation of NEP expression in human endothelial ce...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(95)00077-w
更新日期:1995-01-01 00:00:00
abstract::In order to elucidate the relationship between secretory pathway and processing for precursor molecule of peptide hormones, we performed immunoelectron microscopic studies to localize POMC-derived peptides in mouse cultured L cells (fibroblasts without secretory granules) and in mouse AtT20 cells (ACTH secreting pitui...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(91)90092-4
更新日期:1991-05-01 00:00:00
abstract::Angiotensin-(1-7) [Ang-(1-7)] develops its functions interacting with Mas receptor. Mas receptor was recently identified in the DRG and its activation by Ang-(1-7) resulted in peripheral antinociception against PGE2 hyperalgesia in an opioid-independent pathway. Nevertheless, the mechanism by which Ang-(1-7) induce pe...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2015.04.011
更新日期:2015-07-01 00:00:00
abstract::We compared the in vitro and in vivo biological activities of PG-KII (pGlu-Pro-Asn-Pro-Asp-Glu-Phe-Val-Gly-Leu-Met-NH2), a new peptide belonging to the tachykinin family, related to kassinin, isolated and sequenced from extracts of the skin of the Australian myobatrachid frog Pseudophryne güntheri, with those of the w...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(96)00140-4
更新日期:1996-01-01 00:00:00
abstract::Subpopulations of dopamine (DA) neurons in the ventral mesencephalon have been reported to contain cholecystokinin (CCK) and neurotensin (NT), giving rise to DA, DA/NT, NT/CCK and DA/CCK/NT projections. More precisely, colocalized DA/CCK neurons project mainly to the caudal part of the medial nucleus accumbens, wherea...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(92)90073-c
更新日期:1992-05-01 00:00:00
abstract::Diapause pupae of the swallowtail butterfly Papilio xuthus L. exhibit diapause-green, orange and brownish-orange color polymorphism. Development of orange pupae involves a neuroendocrine factor inducing orange pupa (Orange-Pupa-Inducing Factor, OPIF), which is secreted from the head-thoracic region during late pharate...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2005.06.025
更新日期:2006-03-01 00:00:00
abstract::Opioid receptor analyses of deltorphin A (H-Tyr-D-Met-Phe-His-Leu-Met-Asp-NH2) analogues indicated the following: (a) increased negativity differentially affected affinities (Ki) and selectivity (Ki mu/Ki delta); (b) shifted sequence heptapeptides, [Asp5,Leu6,Met-NH2(7)] and [Asp4,His5,Leu6,Met-NH2(7)], reversed selec...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(93)90006-3
更新日期:1993-01-01 00:00:00
abstract::To investigate possible influences of growth hormone-releasing hormone (GHRH) and somatostatin (SRIF) on auditory perceptional processes, 12 subjects received either placebo (sodium chloride 0.9%), GHRH (50 micrograms), or SRIF (100 micrograms) on different days. Late auditory evoked potentials (AEP) were computed and...
journal_title:Peptides
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/0196-9781(95)00024-e
更新日期:1995-01-01 00:00:00
abstract::Kallikrein-related peptidases (KLKs) are a group of serine proteases, expressed in several tissues. Their activity is regulated by inhibitors including members of the serine protease of Kazal-type (SPINK) family. Recently, we discovered that SPINK6 is expressed in human skin and inhibits KLK5, KLK7, KLK14 but not KLK8...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2011.03.009
更新日期:2011-06-01 00:00:00
abstract::We have investigated the effect of amyloid beta-peptide (Abeta) in rat pheochromocytoma PC 12h and murine C 1300 neuroblastoma cells by using MTT ¿3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) reduction assay. Exposure of the cells to Abeta peptides, Abeta1-40 and its fragment Abeta25-35, induced a con...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(97)00377-x
更新日期:1998-01-01 00:00:00
abstract::In the present study, the C-terminus of endomorphin (Tyr(1)-Pro(2)-Trp/Phe(3)-Phe(4)-NH(2), EMs) analogs [Xaa(4)-R]EMs, modified by substitution of a non-aromatic residue for Phe(4) and ending up with -NH-benzyl, were designed to generate an atypical conformationally constrained peptide set. We investigated the effect...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2007.01.002
更新日期:2007-04-01 00:00:00
abstract::Intravenous (IV) infusions of neurotensin (NT) in anesthetized guinea pigs elicited dose-dependent pressor effects and tachycardia. Both effects were significantly reduced or abolished in guinea pigs given a chronic treatment with the neurotoxin capsaicin. In guinea pig isolated atria NT evoked a positive inotropic an...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(87)90140-9
更新日期:1987-11-01 00:00:00
abstract::Binding of [125I]PACAP-38 to rat liver membranes was investigated. It was rapid at 37 degrees C, reversible, and saturable, and it was time, concentration, and temperature dependent. Scatchard plots showed that [125I]PACAP-38 bound to single noninteracting site(s), and [125I]VIP bound to high- and low-affinity binding...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(94)90206-2
更新日期:1994-01-01 00:00:00
abstract::Pituitary adenylate cyclase-activating peptide (PACAP) is a neuropeptide with strong bronchodilator capacity, present in the human airways. There is recent evidence that PACAP decreases the release of proinflammatory cytokines. We have previously shown that PACAP inhibits neutrophil chemotaxis, but altogether little i...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(02)00149-3
更新日期:2002-10-01 00:00:00
abstract::Deltorphin, a heptapeptide that selectively binds to delta receptors, was intracerebroventricularly administered to mice belonging to the strains C57BL/6 and DBA/2 immediately after training in a one-trial inhibitory avoidance task. The retention performance of both strains was improved by the peptide administration, ...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(90)90063-b
更新日期:1990-05-01 00:00:00
abstract::Mastoparan (MP) peptides, distributed in insect venoms, induce a local inflammatory response post envenomation. Most endogenous MPs share common structural elements within a tetradecapeptide sequence that adopts an amphipathic helix whilst traversing biological membranes and when bound to an intracellular protein targ...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2018.01.007
更新日期:2018-03-01 00:00:00
abstract::A sparse to moderate supply of nerve fibers containing neuropeptide Y-like immunoreactivity (NPY-LI), vasoactive intestinal polypeptide (VIP-LI), substance P (SP-LI), and calcitonin gene-related peptide (CGRP-LI) was demonstrated in the walls of human middle meningeal arteries. Comparison with similar studies on human...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(92)90084-g
更新日期:1992-05-01 00:00:00
abstract::Quantitative receptor autoradiography using Bolton-Hunter iodinated substance P (SP) was used to localize specific sites in the rat hypothalamus. The amount of SP and neurokinin A (NkA) in extracts from discrete areas of the hypothalamus was measured using specific radioimmunoassays. A high density of SP binding sites...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(92)90176-4
更新日期:1992-07-01 00:00:00
abstract::To determine if insulin-like growth factor (IGF)-1 and -2, FSH, or leptin alter IGF-binding protein (IGFBP)-2, -3, -4, and -5 mRNA levels in bovine granulosa and (or) theca cells, granulosa and theca cells were collected from bovine ovarian follicles, plated for 48 h in 10% FCS and then treated for 24 h in serum-free ...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2004.07.008
更新日期:2004-12-01 00:00:00
abstract::The cDNAs encoding the preprohormones of the regulatory peptides cholecystokinin (CCK) and the related gastrin have been identified in a number of vertebrate species. However, from birds only chicken preprogastrin is known. In the present study preproCCK cDNA was identified in two species of birds, ostrich and chicken...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(00)00276-x
更新日期:2000-09-01 00:00:00
abstract::Hypothalamic orexin neurons project to many brain areas, including hindbrain structures such as the nucleus of the solitary tract (NTS) and area postrema (AP), where orexin 1 receptors (OX1Rs) are expressed. Hindbrain administration of orexin-A increases feeding and meal size, and blockade of hindbrain OX1Rs with the ...
journal_title:Peptides
pub_type: 杂志文章,评审
doi:10.1016/j.peptides.2020.170351
更新日期:2020-11-01 00:00:00
abstract::The localization of endozepine-like immunoreactivity in the brain of the frog Rana ridibunda was investigated by indirect immunofluorescence, using an antiserum against synthetic rat octadecaneuropeptide (ODN). A specific immunoreaction was detected in ependymal cells lining the ventricular system of the brain and in ...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(92)90146-t
更新日期:1992-01-01 00:00:00
abstract::C-type natriuretic peptide (CNP) was recently found in the myocardium, but possible insights into differences between atrium and ventricle production are so far lacking. Our aim was to evaluate, in an experimental model of pacing-induced heart failure (HF), plasma and tissue levels of CNP and mRNA expression of the pe...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2008.09.005
更新日期:2008-12-01 00:00:00
abstract::We have isolated TDVDHVFLRFamide (DMS), FDDYGHMRFamide (DSK), and DPKQDFMRFamide from Drosophila melanogaster. These peptides, structurally related by a common C-terminus -XRFamide, where X = L or M, are encoded by three different genes. To determine cellular expression, we have generated antisera to multiple antigeni...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(96)00279-3
更新日期:1997-01-01 00:00:00
abstract::Alzheimer's disease is one of the most common dementia among elderly worldwide. There is no therapeutic drugs until now to treat effectively this disease. One main reason is due to the poorly understood mechanism of Aβ peptide aggregation, which plays a crucial role in the development of Alzheimer's disease. It remain...
journal_title:Peptides
pub_type: 杂志文章,评审
doi:10.1016/j.peptides.2015.04.009
更新日期:2015-07-01 00:00:00
abstract::Apamin is a neurotoxic octadecapeptide from bee venom, which has been shown to inhibit the non-adrenergic, non-cholinergic inhibitory innervation of the smooth muscle of the gut. Since vasoactive intestinal polypeptide (VIP) has been proposed as a possible inhibitory neurotransmitter, the effect of apamin on the recep...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(83)90102-x
更新日期:1983-03-01 00:00:00
abstract::An antifungal protein was isolated from the mushroom Tricholoma giganteum var. golden blessings. The protocol included ion exchange chromatography on DEAE-cellulose, affinity chromatography on Affi-gel blue gel, ion exchange chromatography on CM-cellulose, and gel filtration by fast protein liquid chromatography on Su...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2004.11.009
更新日期:2005-04-01 00:00:00
abstract:BACKGROUND:Since short bowel syndrome (SBS) patients face life-threatening conditions, the development of therapeutic strategies to induce intestinal adaptation has been investigated. Ghrelin, a ligand of growth hormone (GH) secretagogue-receptor that stimulates the release of GH and insulin like growth factor-1 (IGF-1...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2018.06.009
更新日期:2018-08-01 00:00:00
abstract::A lectin was isolated from extracts of fruiting bodies of the mushroom Xerocomus spadiceus using a procedure that involved ion exchange chromatography on DEAE-cellulose, affinity chromatography on Affi-gel blue gel, ion exchange chromatography on CM-cellulose, and gel filtration by fast protein liquid chromatography o...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2003.11.013
更新日期:2004-01-01 00:00:00