Abstract：
:Alzheimer's disease is one of the most common dementia among elderly worldwide. There is no therapeutic drugs until now to treat effectively this disease. One main reason is due to the poorly understood mechanism of Aβ peptide aggregation, which plays a crucial role in the development of Alzheimer's disease. It remains challenging to experimentally or theoretically characterize the secondary and tertiary structures of the Aβ monomer because of its high flexibility and aggregation propensity, and its conformations that lead to the aggregation are not fully identified. In this review, we highlight various structural ensembles of Aβ peptide revealed and characterized by computational approaches in order to find converging structures of Aβ monomer. Understanding how Aβ peptide forms transiently stable structures prior to aggregation will contribute to the design of new therapeutic molecules against the Alzheimer's disease.
journal_name
Peptidesjournal_title
Peptidesauthors
Tran L,Ha-Duong Tdoi
10.1016/j.peptides.2015.04.009subject
Has Abstractpub_date
2015-07-01 00:00:00pages
86-91eissn
0196-9781issn
1873-5169pii
S0196-9781(15)00128-Xjournal_volume
69pub_type
杂志文章,评审相关文献
PEPTIDES文献大全abstract：:Dendroaspis natriuretic peptide (DNP) is one of four members of the natriuretic peptide family sharing functional and structural properties. The purpose of the present study was to elucidate the physiological role of DNP on renal functions and its cellular mechanism in the rabbit kidney. DNP (5 μg/kg/min) infused intr...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2011.12.006
更新日期：2012-01-01 00:00:00
abstract：:Pituitary Adenylate-Cyclase Activating Polypeptide (PACAP) and Tac1 gene-encoded tachykinins (substance P: SP, neurokinin A: NKA) are expressed in capsaicin-sensitive nerves, but their role in nociception, inflammation and vasoregulation is unclear. Therefore, we investigated the function of these neuropeptides and th...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2013.03.003
更新日期：2013-05-01 00:00:00
abstract：:Although many studies have demonstrated the action of motilin on migrating motor complex by using human subjects and relatively large animals, the precise physiological mechanisms of motilin remain obscure. One reason for the lack of progress in this research field is that large animals are generally not suitable for ...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2008.10.006
更新日期：2009-02-01 00:00:00
abstract：:The in vitro activity of six polycationic peptides, buforin II, cecropin P1, indolicidin, magainin II, nisin, and ranalexin, were evaluated against several clinical isolates of gram-positive and gram-negative aerobic bacteria, yeasts, Pneumocystis carinii and Cryptosporidium parvum, by using microbroth dilution method...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/s0196-9781(99)00131-x
更新日期：1999-11-01 00:00:00
abstract：:Phylloseptins are antimicrobial peptides of 19-20 residues which are found in the skin secretions of the Phyllomedusa frogs that inhabit the tropical forests of South and Central Americas. The peptide sequences of PS-1, -2, and -3 carry an amidated C-terminus and they exhibit 74% sequence homology with major variation...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2008.06.022
更新日期：2008-10-01 00:00:00
abstract：:Copeptin can reflect individual's stress state and are correlated with poor outcome of critical illness. The occurrence of postoperative delirium (POD) and cognitive dysfunction (POCD) is associated with worse outcome after coronary artery bypass graft (CABG) surgery. The present study aimed to investigate the ability...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2014.06.016
更新日期：2014-09-01 00:00:00
abstract：:Neuropeptide FF (NPFF) has been shown to act as an endogenous anti-analgesic peptide. In this paper, several peptide analogs of the selective ligand dNP(NMe)AFLFQPQRF-NH(2) modified in the putative address segment, were designed to be selective NPFF(2) receptor probes, synthesized and assayed. One peptide dA(NMe)AAFLF...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2012.07.008
更新日期：2012-09-01 00:00:00
abstract：:We assessed the plasma acyl ghrelin (AG), unacyl ghrelin (UAG), and total ghrelin (TGhr) levels in Chinese adults with pre-diabetes and newly diagnosed diabetes mellitus (NDDM) after an oral glucose tolerance test (OGTT), and abdominal subcutaneous fat area and visceral fat area (VFA) were measured. Fasting AG level w...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2014.07.022
更新日期：2014-10-01 00:00:00
abstract：:The somatostatin analogs D-Phe-Cys-D-Trp-Lys-Thr-Cys-Thr and the corresponding penicillamine compounds have been prepared and tested for their ability to displace [3H]naloxone and [3H] [D-Ala2, D-Leu5]enkephalin from rat brain receptors. While somatostatin and the cystine containing peptide displayed little or no pref...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(85)90026-9
更新日期：1985-01-01 00:00:00
abstract：:WH1fungin, a surfactin cyclopeptide from Bacillus amyloliquefaciens WH1, is firstly reported as a novel immunoadjuvant, which can markedly enhance the immune response when given in mixture with antigens. After intramuscular or subcutaneous immunization, WH1fungin can help to induce both of durable humoral and cellular...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2012.08.021
更新日期：2012-11-01 00:00:00
abstract：:Immunocytochemistry using an antiserum to the C-terminal octapeptide of synenkephalin, proenkephalin(63-70), was performed throughout the rat brain and revealed numerous immunopositive fibers and some cell bodies. The morphology and distribution of synenkephalin immunoreactivity was extremely similar to that of a comm...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(89)90018-1
更新日期：1989-11-01 00:00:00
abstract：:Heat-stable enterotoxin b (STb) of Escherichia coli is a 48-amino acid basic, disulfide-bonded peptide that causes intestinal secretion in experimental animal models. Recent evidence suggests that the in vivo mechanism of STb action involves release of 5-hydroxytryptamine (5-HT) and production of prostaglandin E2 (PGE...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(96)00033-2
更新日期：1996-01-01 00:00:00
abstract：:TRH and PS-24 (a TRH peptidase resistant analogue) induce different effects on body temperature and motor activity in rats kept at 4 degrees C. PS-24 induced hypothermia, but TRH did not. PS-24 induced hypermotility, while TRH induced slight hypomotility. The thermal effect of TRH in hypophysectomized rats was similar...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/s0196-9781(81)80024-1
更新日期：1981-07-01 00:00:00
abstract：:HPLC characterization of tilapia pituitary endorphins using an antibody specific for N-terminally acetylated endorphins yielded three major peaks in the neurointermediate lobe, but none in the pars distalis. The melanotropes secreted two of the immunoreactive products in vitro, one of which coeluted with Xenopus laevi...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(94)00204-j
更新日期：1995-01-01 00:00:00
abstract：:The effect of vasoactive intestinal peptide (VIP) on the nerve-stimulated contraction, tissue oxygenation, lipid peroxidation and antioxidant enzymes activities-superoxide dismutase and catalase was investigated in the rat gastrocnemius muscle exposed to 4 h ischemia-4hr reperfusion. Ischemia caused significant decrea...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/s0196-9781(96)00289-6
更新日期：1997-01-01 00:00:00
abstract：:Modification to the structure of glucagon has provided a number of glucagon receptor antagonists with possible therapeutic application for diabetes. These novel peptide analogs include desHis(1)Pro(4)Glu(9)-glucagon and desHis(1)Pro(4)Glu(9)(Lys(30)PAL)-glucagon. This study has evaluated the metabolic benefits of once...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2014.08.002
更新日期：2014-10-01 00:00:00
abstract：:Binding sites in the rat forebrain were characterized using (125I-Tyr4)bombesin as a receptor probe. Pharmacology experiments indicate that gastrin releasing peptide (GRP) and the GRP fragments GRP as well as Ac-GRP inhibited radiolabeled (Tyr4)bombesin binding with high affinity. Biochemistry experiments indicated th...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(85)90018-x
更新日期：1985-01-01 00:00:00
abstract：:The effects of intracerebroventricular (ICV) and intravenous injections of bombesin (BBS) on food intake were investigated in turkeys. Adult turkey hens were injected ICV with 50 to 1000 ng of BBS. In addition, the effect of pretreatment with the BBS antagonist [d-Arg1, D-Phe5, D-Trp7,9, Leu11]-substance P was investi...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(89)90030-2
更新日期：1989-03-01 00:00:00
abstract：:The relaxant effect of a novel VIP analog, [Arg15,20,21Leu17]-VIP-Gly-Lys-Arg-NH2 was compared with that of the original VIP in the same guinea pig trachea precontracted by carbachol in vitro. The VIP analog caused significantly and concentration-dependent relaxation similarly to the original VIP. In contrast to the o...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/s0196-9781(97)00457-9
更新日期：1998-01-01 00:00:00
abstract：:Hypothalamic orexin neurons project to many brain areas, including hindbrain structures such as the nucleus of the solitary tract (NTS) and area postrema (AP), where orexin 1 receptors (OX1Rs) are expressed. Hindbrain administration of orexin-A increases feeding and meal size, and blockade of hindbrain OX1Rs with the ...
journal_title：Peptides
pub_type： 杂志文章,评审
doi：10.1016/j.peptides.2020.170351
更新日期：2020-11-01 00:00:00
abstract：:Antimicrobial peptides (AMPs) are believed to be a promising class of antimicrobial agents against bacteria and fungi. To promote the clinical use of AMPs, their antimicrobial activity and susceptibility to protease degradation should be further improved. The antimicrobial peptide Jelleine-I was originally isolated fr...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2018.11.006
更新日期：2019-02-01 00:00:00
abstract：:Angiotensin II binding sites were localized and quantified in individual brain nuclei from single rats by incubation of tissue sections with 1 nM 125I-[Sar1]-angiotensin II, [3H]-Ultrofilm autoradiography, computerized microdensitometry and comparison with 125I-standards. High angiotensin II binding was present in the...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(86)90044-6
更新日期：1986-07-01 00:00:00
abstract：:The experiments reported here investigate the conditionability, using taste aversion conditioning, of the antagonistic effects of alpha-MSH on the thermoregulatory changes associated with injection of bacterial endotoxin lipopolysaccharide (LPS) in rats. Animals were administered LPS and then given alpha-MSH, as an un...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(94)90182-1
更新日期：1994-01-01 00:00:00
abstract：:We tested the effects of intra-lateral septal infusions of neuropeptide Y (NPY) combined with systemic injections of topiramate in the DRL-72s paradigm and the elevated plus-maze test in male Wistar rats. Intra-lateral septal infusions of desipramine (5.0 microg/microl; P<0.05) or intra-lateral septal infusions of NPY...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2010.03.012
更新日期：2010-06-01 00:00:00
abstract：:A new series of analogues of the potent opiate-like peptides dermorphins (mainly tetra- and pentapeptides) were synthesized in order to better evaluate the structure-activity relationships. Relative potencies were referred to dermorphin (H-Tyr-D-Ala-Phe-Gly-Tyr-Pro-Ser-NH2), the prototype of this class of frog skin pe...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(82)90009-2
更新日期：1982-09-01 00:00:00
abstract：:This study was performed to identify the efferents of the dorsal raphe nucleus (DRN), particularly in regard to nociception. Phaseolus vulgaris leucoagglutinin (PHA-L) was microiontophoresed into the DRN and visualized immunocytochemically; PHA-L-immunoreactive (-IR) fibers and terminals were identified in the forebra...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(93)90013-7
更新日期：1993-01-01 00:00:00
abstract：:In this study, we evaluated the bradykinin potentiating activity and ACE inhibitory activity of several Ang-(1-7)-related peptides: Ang-(2-7), Ang-(3-7), Ang-(4-7), Ang-(1-6), Ang-(1-5) and the selective antagonist of Ang-(1-7): D-[Ala7]Ang-(1-7) (A-779). In vivo experiments were performed in freely moving Wistar rats...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/s0196-9781(99)00031-5
更新日期：1999-01-01 00:00:00
abstract：:Intracerebroventricular injections of rat hypothalamic growth hormone-releasing factor (rhGRF) were examined for effects on food intake in free-feeding rats. It was found that, in picomole doses, rhGRF had a stimulatory effect on food intake. Examination of higher doses of rhGRF revealed a decrease in the facilitatory...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(88)90220-3
更新日期：1988-01-01 00:00:00
abstract：:The major amyloid-beta (Abeta) peptides found in the brain of familial and late onset Alzheimer's disease include the full-length Abeta1-42 and N-terminally truncated, pyroglutamylated peptides Abetap3-42 and Abetap11-42. The biophysical properties of Abeta1-42 have been extensively studied, yet little is known about ...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2009.01.027
更新日期：2009-05-01 00:00:00
abstract：:In non-pregnant goats, ovariectomy on day 12 of oestrous cycle resulted in parallel decrease of oxytocin and progesterone jugular concentration. Similarly, luteolysis, indicated by decreasing progesterone concentration, was accompanied by simultaneous release of oxytocin and oxytocin-associated neurophysins (mean of n...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(87)90063-5
更新日期：1987-09-01 00:00:00
