Ablation of glucagon receptor signaling by peptide-based glucagon antagonists improves glucose tolerance in high fat fed mice.

abstract：:We have attempted to demonstrate a pancreatic secretory response to intraduodenal amino acids in the anesthetized cat. In four cats stimulated with supramaximal doses of secretin, protein concentrations in pancreatic juice were measured after intraduodenal bolus injection of various amino acids, IV CCK, or electrical ...

journal_title：Peptides

authors： Johnson C,Jeanningros R,Sarles H

更新日期：1982-03-01 00:00:00

abstract：:In this study, antimicrobial peptide S-thanatin (Ts) was chemically synthesized and linked to keyhole limpet hemocyanin (KLH) and bovine serum albumin (BSA) by carbodiimide reagent. Rabbits were immunized with Ts-KLH and polyclonal antibody against Ts was purified by fractional precipitation of ammonium sulfate, coupl...

journal_title：Peptides

authors： Wu G,Wang S,Wang X,Li X,Deng X,Shen Z,Xi T

更新日期：2011-07-01 00:00:00

abstract：:Morphologic and immunohistochemical studies were conducted to ascertain whether pumiliotoxin-B (PTX-B), an indolizine alkaloid from the skin of the Neotropical dendrobatid frog, Dendrobates pumilio, affects the anatomic and immunohistochemical features of the electrically stimulated mouse vas deferens preparations. PT...

journal_title：Peptides

authors： D'Este L,Falconieri-Erspamer G,Severini C,Erspamer V,Renda TG

更新日期：1999-01-01 00:00:00

abstract：:Cone snails have evolved an assortment of venom peptides as an evolutionary strategy for rapid prey immobilization and defence. Earlier studies estimated approximately 100 conopeptides per species. In this study we optimized liquid chromatography and electrospray ionization mass spectrometry for the detection of conop...

journal_title：Peptides

authors： Davis J,Jones A,Lewis RJ

更新日期：2009-07-01 00:00:00

abstract：:The cross-immunoreactivity, topography, and fiber projections of the alpha MSH-immunoreactive specific neurons in the forebrain of the rat appear to be distinctly different from that of the neurons in the hypothalamic arcuate opiocortin system. The cell bodies, immunoreactive only to alpha-MSH, have a specific pattern...

journal_title：Peptides

authors： Piekut DT,Knigge KM

更新日期：1984-11-01 00:00:00

abstract：:We administered prolactin-releasing peptide (PrRP) or anti-PrRP antiserum to goldfish in fresh water and analyzed their effects on prolactin and osmoregulatory mechanisms. The pituitary mRNA level of prolactin increased by PrRP but decreased by anti-PrRP. The rate of water inflow in the gills decreased by PrRP and inc...

journal_title：Peptides

authors： Fujimoto M,Sakamoto T,Kanetoh T,Osaka M,Moriyama S

更新日期：2006-05-01 00:00:00

abstract：:Several considerations led us to directly measure, using radioimmunoassay, the levels of dynorphin-A(1-8), cholecystokinin-8, and Met5-enkephalin-Arg6-Gly7-Leu8 (MERGL) in lysed-P2 membranes, membranes incubated 60 min at 25 degrees C in 50 mM TRIS-HCl at pH 7.4, and membranes preincubated 60 min at 25 degrees C in TR...

journal_title：Peptides

authors： Rothman RB,Danks JA,Iadarola MJ

更新日期：1987-07-01 00:00:00

abstract：:An antifungal protein was isolated from the mushroom Tricholoma giganteum var. golden blessings. The protocol included ion exchange chromatography on DEAE-cellulose, affinity chromatography on Affi-gel blue gel, ion exchange chromatography on CM-cellulose, and gel filtration by fast protein liquid chromatography on Su...

journal_title：Peptides

authors： Guo Y,Wang H,Ng TB

更新日期：2005-04-01 00:00:00

abstract：:Despite its wide distribution in the central nervous system, the presence of Neuropeptide Y (NPY) in peripheral tissues has been detected. White adipose tissue (WAT) is a new site of NPY synthesis and secretion. The development of brown-like adipocytes in WAT is controlled by hypothalamic NPY neurons through interacti...

journal_title：Peptides

authors： Wan Y,Xue R,Wang Y,Zhang Q,Huang S,Wu W,Ye H,Zhang Z,Li Y

更新日期：2015-01-01 00:00:00

abstract：:The functional role of the C-terminal amide group (-CONH2) of the molluscan regulatory peptide FMRFamide has been examined in two sets of analogues based on FnLKFamide and FnLRFamide (nL = norleucine). In each series the amide group was replaced by -CONHCH3, -CON(CH3)2, -CONHNH2, -COOCH3, -CH2OH, and -COOH. The analog...

journal_title：Peptides

authors： Geraghty RF,Irvine GB,Williams CH,Cottrell GA

更新日期：1994-01-01 00:00:00

abstract：:Tissue inhibitor of metalloproteinases-2 (TIMP-2) inhibits angiogenesis by several mechanisms involving either MMP inhibition or direct endothelial cell binding. The primary aim of this study was to identify the TIMP-2 region involved in binding to the previously identified receptor integrin α3β1, and to determine whe...

journal_title：Peptides

authors： Seo DW,Saxinger WC,Guedez L,Cantelmo AR,Albini A,Stetler-Stevenson WG

更新日期：2011-09-01 00:00:00

abstract：:We previously demonstrated that intracerebroventricular (i.c.v.) administration of the substance P (SP) aminoterminal fragment SP(1-7) attenuates the expression of morphine withdrawal in the male rat. In this study we have used a synthetic analogue of this peptide, i.e. the SP(1-7) amide showing higher binding potency...

journal_title：Peptides

authors： Zhou Q,Carlsson A,Botros M,Fransson R,Sandström A,Gordh T,Hallberg M,Nyberg F

更新日期：2009-12-01 00:00:00

abstract：:Endokinins are novel tachykinins encoded on the human TAC4 and consist of Endokinin A (EKA), B (EKB), C (EKC) and D (EKD). To date, the function of Endokinins in pain processing was not fully understood. Therefore the aim of this study was to investigate the effects of Endokinin A/B (EKA/B, the common C-terminal decap...

journal_title：Peptides

authors： Yang Y,Dong S

更新日期：2010-01-01 00:00:00

abstract：:A newly developed system of isolated rat colonic epithelial cells was utilized for a comprehensive study of protein synthesis influenced by gastrin. We found that synthetic human gastrin (0.01-100 nM) increased the incorporation of [35S]methionine into proteins within 2 hours. Peak incorporation was observed with 10 n...

journal_title：Peptides

authors： Yassin RR,Clearfield HR,Katz SM,Murthy SN

更新日期：1991-01-01 00:00:00

abstract：:Obestatin is a 23-amino-acid peptide originally regarded as an anorexigenic factor. However, most of the subsequent studies failed to confirm the initially reported anorexigenic properties of obestatin. Obestatin is incapable of crossing the blood brain barrier (BBB), which may affect its biological function. Here, we...

journal_title：Peptides

authors： Ren G,He Z,Cong P,Chen H,Guo Y,Yu J,Liu Z,Ji Q,Song Z,Chen Y

更新日期：2013-04-01 00:00:00

abstract：:Recent refinements in methodology now permit the study of endogenous peptide hormones in their individual target cells. The investigations reported here deal with the question of whether endogenous ACTH can be detected in its target cells in the highly active adrenal gland of the normally lactating rat. This question ...

journal_title：Peptides

authors： Nolin JM

更新日期：1980-10-01 00:00:00

abstract：:The major amyloid-beta (Abeta) peptides found in the brain of familial and late onset Alzheimer's disease include the full-length Abeta1-42 and N-terminally truncated, pyroglutamylated peptides Abetap3-42 and Abetap11-42. The biophysical properties of Abeta1-42 have been extensively studied, yet little is known about ...

journal_title：Peptides

authors： Sanders HM,Lust R,Teller JK

更新日期：2009-05-01 00:00:00

abstract：:The effect of melanin-concentrating hormone (MCH) on the release of alpha-melanocyte stimulating hormone (alpha-MSH) from the tilapia pituitary gland was studied in vitro. In a superfusion set up, 10 nM to 1 microM synthetic salmon MCH caused a concentration-dependent inhibition of alpha-MSH release from tilapia neuro...

journal_title：Peptides

authors： Gröneveld D,Balm PH,Wendelaar Bonga SE

更新日期：1995-01-01 00:00:00

abstract：:Endocrine regulation in vertebrates is critical for the adaptation and regulation of homeostasis. The G protein-coupled receptor (GPCR) signaling transduction system represents one of the most ancient forms of cell surface signaling. Recently, comparative sequence analysis has aided in the identification and pairing o...

journal_title：Peptides

authors： Chang CL,Roh J,Hsu SY

更新日期：2004-10-01 00:00:00

abstract：:Vestibular compensation is a process of CNS plasticity that is correlated to a return of resting activity in medial vestibular nucleus (MVN) neurons ipsilateral to a peripheral vestibular deafferentation. Systemic administration of melanocortin peptides accelerates the compensation process; the ACTH/MSH(4-9) analogue,...

journal_title：Peptides

authors： Gilchrist DP,Darlington CL,Smith PF

更新日期：1996-01-01 00:00:00

abstract：:Bacillus thuringiensis Cry toxins recognizes their target cells in part by the binding to glycosyl-phosphatidyl-inositol (GPI) anchored proteins such as aminopeptidase-N (APN) or alkaline phosphatases (ALP). Treatment of Tenebrio molitor brush border membrane vesicles (BBMV) with phospholipase C that cleaves out GPI-a...

journal_title：Peptides

authors： Zúñiga-Navarrete F,Gómez I,Peña G,Bravo A,Soberón M

更新日期：2013-03-01 00:00:00

abstract：:Neurotensin-like immunoreactive neuronal perikarya, fibers and terminals in in the rat hypothalamus were investigated by light and electron microscopic immunocytochemistry. Distributional density and pattern of these elements were clarified. Fine structure of immunoreactive neuronal perikarya with respect to developme...

journal_title：Peptides

authors： Ibata Y,Kawakami F,Fukui K,Okamura H,Obata-Tsuto HL,Tsuto T,Terubayashi H

更新日期：1984-01-01 00:00:00

abstract：:Recent reports suggest that arginine vasopressin (AVP) may be an endogenous antipyretic peptide and a mediator of febrile convulsions [10,12]. The spontaneously seizing Mongolian gerbil was used to investigate the thermoregulatory, behavioral and seizure modulatory effects of AVP. Injection of AVP (1.0 and 5.0 microgr...

journal_title：Peptides

authors： Lee RJ,Lomax P

更新日期：1983-11-01 00:00:00

abstract：:A novel protease inhibitor, designated mungoin, with both antifungal and antibacterial activities, and exhibiting a molecular mass of 10kDa in SDS-polyacrylamide gel electrophoresis, was isolated from mung bean (Phaseolus mungo) seeds. The isolation procedure involved a combination of extraction, ammonium sulfate prec...

journal_title：Peptides

authors： Wang S,Lin J,Ye M,Ng TB,Rao P,Ye X

更新日期：2006-12-01 00:00:00

abstract：:HP-1 is the most abundant human representative of a recently discovered class of neutrophil cystine- and arginine-rich peptides. These peptides have many potentially regulatory activities expressed at nanomolar concentrations. To establish the levels of HP-1 that can accumulate in human lung tumors and nondiseased lun...

journal_title：Peptides

authors： Bateman A,Singh A,Jothy S,Fraser R,Esch F,Solomon S

更新日期：1992-01-01 00:00:00

abstract：:The heptadecapeptide, orphanin FQ or nociceptin (Phe-Gly-Phe-Thr-Gly-Ala-Arg-Lys-Ser-Ala-Arg-Lys-Leu-Ala-Asn-Gln), originally isolated from rat brain has been identified as an endogenous ligand for the orphan opioid-like receptor. Although orphanin FQ shares some sequence and structural homology with kappa-opioid pept...

journal_title：Peptides

authors： Kavaliers M,Choleris E,Saucier DM

更新日期：1997-01-01 00:00:00

abstract：:The incretin hormones, glucose dependent insulinotropic polypeptide (GIP) and glucagon-like peptide 1 (GLP-1), potentiate insulin secretion and are responsible for the majority of insulin secretion that occurs after a meal. They may also, however, have a fundamental role in pancreatic beta cell development and functio...

journal_title：Peptides

authors： Omar B,Ahlkvist L,Yamada Y,Seino Y,Ahrén B

更新日期：2016-05-01 00:00:00

abstract：:Due to recent emergence of fungal pathogens resistant to current antifungal therapies, several studies have been focused on screening of plant peptides to find novel compounds having antifungal activities. Here, a novel antifungal plant peptide, with molecular mass of 1230 Da was purified from fruits of Trapa natans b...

journal_title：Peptides

authors： Mandal SM,Migliolo L,Franco OL,Ghosh AK

更新日期：2011-08-01 00:00:00

abstract：:Neural input to distinct and separate populations of CRF-immunoreactive (ir) neurons in rat forebrain was investigated. The relationship of opiocortin and/or catecholamine fibers to different groups of CRF-containing neurons was elucidated using single and dual labeling immunocytochemical procedures. Antibodies to CRF...

journal_title：Peptides

authors： Hornby PJ,Piekut DT

更新日期：1989-11-01 00:00:00

abstract：:To confirm and extend the results of previous studies which demonstrated central cardiovascular effects of vasopressin in anesthetized rats, we determined blood pressure and heart rate changes for 30 minutes after intracerebroventricular injections of arginine vasopressin, arginine vasotocin and oxytocin in conscious ...

journal_title：Peptides

authors： Zerbe RL,Kirtland S,Faden AI,Feuerstein G

更新日期：1983-09-01 00:00:00