Unexpectedly high levels of opioid peptides in rat brain membranes.

abstract：:Urotensin II (UII), first identified from goby urophysis, is a potent vasoactive peptide hormone and an endogenous ligand for an orphan G protein-coupled receptor GPR14, now named urotensin II receptor (UT-R). In addition to its vascular actions, UII has been shown to have mitogenic effects on tumor growth and some re...

journal_title：Peptides

authors： Morimoto R,Satoh F,Murakami O,Totsune K,Arai Y,Suzuki T,Sasano H,Ito S,Takahashi K

更新日期：2008-05-01 00:00:00

abstract：:Arginine-vasopressin (AVP) is a hypothalamic hormone that, like CRH, stimulates the pituitary release of ACTH, thereby activating adrenal glucocorticoid secretion. Evidence indicates that rat adrenal medulla contains a CRH-ACTH system duplicating that existing at the hypothalamo-pituitary level and involved in the par...

journal_title：Peptides

authors： Mazzocchi G,Malendowicz LK,Rebuffat P,Tortorella C,Nussdorfer GG

更新日期：1997-01-01 00:00:00

abstract：:The aim of our study was to determine whether a meal modifies the antisecretory response induced by PYY and the structural requirements to elicit antisecretory effects of analogue PYY(22-36) for potential antidiarrhea therapy. The variations in short-circuit current (Isc) due to the modification of ionic transport acr...

journal_title：Peptides

authors： Eto B,Boisset M,Eden P,Balasubramaniam A,Desjeux JF

更新日期：1995-01-01 00:00:00

abstract：:To study structure-activity relationships of growth hormone-releasing hormone (GHRH), a competitive binding assay was developed using cloned porcine adenopituitary GHRH receptors expressed in human kidney 293 cells. Specific binding of [His1, 125I-Tyr10,Nle27]hGHRH(1-32)-NH2 increased linearly with protein concentrati...

journal_title：Peptides

authors： Hassan HA,Hsiung HM,Zhang XY,Smith DP,Smiley DL,Heiman ML

更新日期：1995-01-01 00:00:00

abstract：:A short neuropeptide F (sNPF) precursor and a sNPF receptor (sNPFR) were characterized for the mosquito, Anopheles gambiae. The sNPFR was expressed in CHO-K1 cells, and it exhibited high affinity binding, IC(50) approximately 3-5 nM, for specific sNPFs. sNPF1 potently inhibited forskolin-stimulated cAMP production by ...

journal_title：Peptides

authors： Garczynski SF,Crim JW,Brown MR

更新日期：2007-01-01 00:00:00

abstract：:We evaluated behavior and cognitive performance in a line of transgenic mice that overexpress the rat gene for vasopressin. Open field testing revealed greatest habituation in homozygous mice. Passive avoidance performance indicated equal learning and memory ability of transgenic compared to normal mice. Drinking beha...

journal_title：Peptides

authors： Miller M,Haroutunian V,Wiltshire-Clement M

更新日期：1995-01-01 00:00:00

abstract：:Kisspeptins are biologically active cleavage peptides of the KiSS-1 gene products with important roles in the suppression of tumor metastasis and in the reproduction. The aim of the present study is to clarify changes of the expression of kisspeptins and kisspeptin receptor in the kidney with and without chronic renal...

journal_title：Peptides

authors： Shoji I,Hirose T,Mori N,Hiraishi K,Kato I,Shibasaki A,Yamamoto H,Ohba K,Kaneko K,Morimoto R,Satoh F,Kohzuki M,Totsune K,Takahashi K

更新日期：2010-10-01 00:00:00

abstract：:Endocrine tumor cells in culture and in vitro cleavage assays have shown that PC1 and PC2 are capable of processing pro-CCK into smaller, intermediate and final, bioactive forms. Similar studies have shown that PC5 has the ability to process a number of propeptides. Here, we use GT1-7 (mouse hypothalamic) and SK-N-MC ...

journal_title：Peptides

authors： Cain BM,Vishnuvardhan D,Beinfeld MC

更新日期：2001-08-01 00:00:00

abstract：:The renin-angiotensin system (RAS) is now recognized as an important modulator of body metabolic processes. The discovery of angiotensin-converting enzyme 2 (ACE2) has renewed interest in the potential therapeutic role of RAS modulation. Recent studies have pointed out the importance of the local balance between ACE/A...

journal_title：Peptides

authors： Moreira de Macêdo S,Guimarães TA,Feltenberger JD,Sousa Santos SH

更新日期：2014-12-01 00:00:00

abstract：:CR 1409, a glutaramic acid derivative with competitive cholecystokinin-antagonistic activity, was administered IP and evaluated in comparison with proglumide (the model CCK-receptor antagonist), gabexate (protease inhibitor) and PGE2 (cytoprotective) on two different models of experimental pancreatitis. Acute pancreat...

journal_title：Peptides

authors： Makovec F,Bani M,Cereda R,Chistè R,Revel L,Rovati LC,Setnikar I,Rovati LA

更新日期：1986-11-01 00:00:00

abstract：:Dissociated neurointermediate lobe cells (75%) bound [biotinyl-Ser1]corticotropin releasing hormone (bio-CRH) and secreted adrenocorticotropin [ACTH(25-39)] in a reverse hemolytic plaque assay (RHPA). The bio-CRH was rapidly internalized (less than 1 min) in vesicles and scattered vacuoles. Plaque percentages increase...

journal_title：Peptides

authors： Childs GV

更新日期：1990-07-01 00:00:00

abstract：:The detection of the prodynorphin gene in anuran amphibians and lungfishes may indicate that this gene arose as a result of the duplication of the proenkephalin gene early during the divergence of the Sarcopterygii, or that this gene may predate the divergence of the ray-finned fish and the lobe-finned fish. The cloni...

journal_title：Peptides

authors： Alrubaian J,Lecaude S,Barba J,Szynskie L,Jacobs N,Bauer D,Brown C,Kaminer I,Bagrosky B,Dores RM

更新日期：2006-04-01 00:00:00

abstract：:Previously, calcitonin gene-related peptide (CGRP) decreased food intake when administered ICV but not when administered peripherally to rats. Amylin, which has a close structural homology to CGRP, reduced food intake administered IP at concentrations higher than those previously tested for CGRP. We examined the effec...

journal_title：Peptides

authors： Morley JE,Farr SA,Flood JF

更新日期：1996-01-01 00:00:00

abstract：:The purpose of this study was to examine the resting and exercise response patterns of plasma Peptide F immunoreactivity (ir) to altitude exposure (4300 m) and caffeine ingestion (4 mg.kg b.w.-1). Nine healthy male subjects performed exercise tests to exhaustion (80-85% VO2max) at sea level (50 m), during an acute alt...

journal_title：Peptides

authors： Kraemer WJ,Rock PB,Fulco CS,Gordon SE,Bonner JP,Cruthirds CD,Marchitelli LJ,Trad L,Cymerman A

更新日期：1988-09-01 00:00:00

abstract：:We examined the expressions of the prepro-orexin gene in the lateral hypothalamic area (LHA), the genes of the neuropeptide Y (NPY) and proopiomelanocortin (POMC) in the arcuate nucleus (ARC), the orexin type 1 receptor (OX1R) gene in the ventromedial hypothalamic nucleus (VMH) and the orexin type 2 receptor (OX2R) ge...

journal_title：Peptides

authors： Yamamoto Y,Ueta Y,Yamashita H,Asayama K,Shirahata A

更新日期：2002-09-01 00:00:00

abstract：:In the present study, the C-terminus of endomorphin (Tyr(1)-Pro(2)-Trp/Phe(3)-Phe(4)-NH(2), EMs) analogs [Xaa(4)-R]EMs, modified by substitution of a non-aromatic residue for Phe(4) and ending up with -NH-benzyl, were designed to generate an atypical conformationally constrained peptide set. We investigated the effect...

journal_title：Peptides

authors： Yu Y,Shao X,Wang CL,Liu HM,Cui Y,Fan YZ,Liu J,Wang R

更新日期：2007-04-01 00:00:00

abstract：:The purpose of this study is to elucidate the mechanism of action and site of action of calcitonin gene-related peptide (CGRP) and its effects on calcium concentrations in two types of cardiomyocytes, neonatal and adult, by employing real-time fluorescence imaging. CGRP caused an increase in intramyocytic calcium with...

journal_title：Peptides

authors： Bick RJ,Poindexter BJ,Davis RA,Schiess MC

更新日期：2005-11-01 00:00:00

abstract：:Glucocorticoids have been shown to decrease CRF receptor binding in the anterior pituitary. To determine whether glucocorticoids or CRF peptide modulate CRF-R1 gene expression, CRF-R1 mRNA levels in rat pituitary and brain were measured after administration of a synthetic glucocorticoid, dexamethasone (DEX) or rat/hum...

journal_title：Peptides

authors： Zhou Y,Spangler R,LaForge KS,Maggos CE,Ho A,Kreek MJ

更新日期：1996-01-01 00:00:00

abstract：:The effects of CCK-8s and desulfated CCK-8 at concentrations ranging from 10(-14) to 10(-6) M were studied in vitro on several functions of human peripheral neutrophils: adherence to substrate, mobility (spontaneous and directed by a chemical gradient or chemotaxis), ingestion of inert particles (latex beads) or cells...

journal_title：Peptides

authors： Carrasco M,Del Rio M,Hernanz A,De la Fuente M

更新日期：1997-01-01 00:00:00

abstract：:Hymenistatin I (HS-I), a cyclic octapeptide [c-(-Pro-Pro-Tyr-Val-Pro-Leu-Ile-Ile-)], was synthesized by the solid-phase peptide synthesis method and examined for its immunosuppressive activity in the humoral and cellular immune responses. The peptide activity was tested on cell lines producing various cytokines. The r...

journal_title：Peptides

authors： Cebrat M,Wieczorek Z,Siemion IZ

更新日期：1996-01-01 00:00:00

abstract：:Venoms from cone snails (genus Conus) can be seen as an untapped cocktail of biologically active compounds, being increasingly recognized as an emerging source of peptide-based therapeutics. Cone snails are considered to be specialized predators that have evolved the most sophisticated peptide chemistry and neuropharm...

journal_title：Peptides

authors： Peigneur S,Van Der Haegen A,Möller C,Waelkens E,Diego-García E,Marí F,Naudé R,Tytgat J

更新日期：2013-03-01 00:00:00

abstract：:Besides its well known endocrinological effects, thyrotropin-releasing hormone (TRH) has potential clinical value in the treatment of neurotrauma and various neurologic and psychiatric disorders. The aim of this study was to assess if transdermal delivery of TRH and its analogue, M-TRH, in the presence of enhancers, i...

journal_title：Peptides

authors： Magnusson BM,Koskinen LO,Koch M,Karlsson K

更新日期：2001-01-01 00:00:00

abstract：:One major cause for discrepancies in results from animal experimental studies is the use of different animal strains and suppliers. We have previously reported that Wistar rats from five different suppliers display profound differences in ethanol intake and behavior. One of the neurobiological processes that could be ...

journal_title：Peptides

authors： Palm S,Roman E,Nylander I

更新日期：2012-07-01 00:00:00

abstract：:Diapause pupae of the swallowtail butterfly Papilio xuthus L. exhibit diapause-green, orange and brownish-orange color polymorphism. Development of orange pupae involves a neuroendocrine factor inducing orange pupa (Orange-Pupa-Inducing Factor, OPIF), which is secreted from the head-thoracic region during late pharate...

journal_title：Peptides

authors： Yamanaka A,Adachi M,Imai H,Uchiyama T,Inoue M,Islam AT,Kitazawa C,Endo K

更新日期：2006-03-01 00:00:00

abstract：:To investigate possible influences of growth hormone-releasing hormone (GHRH) and somatostatin (SRIF) on auditory perceptional processes, 12 subjects received either placebo (sodium chloride 0.9%), GHRH (50 micrograms), or SRIF (100 micrograms) on different days. Late auditory evoked potentials (AEP) were computed and...

journal_title：Peptides

authors： Hartmann A,Dietl T,Krumrey K,Vogl L,Dirlich G,Holsboer F,Heuser-Link M

更新日期：1995-01-01 00:00:00

abstract：:Neurotensin exerts its actions in the central nervous system and the periphery through three identified receptors. Two of them, the NTS2 and NTS3, display unusual properties either because of their complex signal transduction mechanisms (NTS2) or because of their structural composition as a non-G-protein-coupled recep...

journal_title：Peptides

authors： Mazella J,Vincent JP

更新日期：2006-10-01 00:00:00

abstract：:Rats were injected IP with a 0.1 mg/kg dose of MIF-I, naloxone, dynorphin, [D-Phe4]-Met-enkephalin, [D-Ala2, F5Phe4]-Met-enkephalin-NH2, or the diluent vehicle, placed in their home cages for ten minutes, and then given ad lib access to either 20% sucrose, 10% sucrose, water, 0.01% quinine, or 0.02% quinine in a repea...

journal_title：Peptides

authors： Olson RD,Kastin AJ,Olson GA,King BM,Von Almen TK,Berzas MC,Ibanez ML,Coy DH

更新日期：1980-01-01 00:00:00

abstract：:Neurotensin (NT) produces behavioral and physiological effects, including analgesia and hypotheria, when administered into the CNS. Fischer and Lewis rats exhibit differential behavioral responses to central NT receptor activation. To further characterize these differences, we assessed central NT-induced analgesia and...

journal_title：Peptides

authors： Bauco P,Rompré PP

更新日期：2003-08-01 00:00:00

abstract：:Unilateral intracerebroventricular (ICV) injections of a high dose of CCK7 have been reported to elicit barrel rotations accompanied by contralateral postural asymmetry; there was no spontaneous locomotor activity other than barrel rolling. The aim of the present study was to investigate the effects of lower doses of ...

journal_title：Peptides

authors： Morency MA,Ross GM,Hesketh D,Mishra RK

更新日期：1987-11-01 00:00:00

abstract：:Neurotensin-like immunoreactive neuronal perikarya, fibers and terminals in in the rat hypothalamus were investigated by light and electron microscopic immunocytochemistry. Distributional density and pattern of these elements were clarified. Fine structure of immunoreactive neuronal perikarya with respect to developme...

journal_title：Peptides

authors： Ibata Y,Kawakami F,Fukui K,Okamura H,Obata-Tsuto HL,Tsuto T,Terubayashi H

更新日期：1984-01-01 00:00:00