Abstract：
:CR 1409, a glutaramic acid derivative with competitive cholecystokinin-antagonistic activity, was administered IP and evaluated in comparison with proglumide (the model CCK-receptor antagonist), gabexate (protease inhibitor) and PGE2 (cytoprotective) on two different models of experimental pancreatitis. Acute pancreatitis was induced in mice by six IP injections of 50 micrograms/kg caerulein at hourly intervals. The drugs were administered 30 minutes before each caerulein administration. Blood samples and pancreata were collected 3 hours after the last caerulein injection. In the second experiment, pancreatitis was induced in rats by injecting 0.3 ml 6% sodium taurocholate interstitially into the pancreas. The drugs were administered twice, 30 minutes before and 3 hours after taurocholate. The animals were killed 6 hours after laparotomy and blood samples and pancreata were collected. CR 1409 exhibited on both pancreatitis models a protective effect in a dose range of 0.3-10 mg/kg. Proglumide exhibited a protective activity at higher doses (200-400 mg/kg). Gabexate and PGE2 were effective only in pancreatitis induced by taurocholate in a dose range of 30-60 mg/kg and 60-130 micrograms/kg respectively. These results, showing a high protective effect of CR 1409 on different models of acute pancreatitis, suggest an important role of CCK in the pathogenesis of pancreatitis.
journal_name
Peptidesjournal_title
Peptidesauthors
Makovec F,Bani M,Cereda R,Chistè R,Revel L,Rovati LC,Setnikar I,Rovati LAdoi
10.1016/0196-9781(86)90147-6subject
Has Abstractpub_date
1986-11-01 00:00:00pages
1159-64issue
6eissn
0196-9781issn
1873-5169pii
0196-9781(86)90147-6journal_volume
7pub_type
杂志文章相关文献
PEPTIDES文献大全abstract：:The aim of the present study was to correlate the development of the renin angiotensin system (RAS) in the kidney of the rat with the development of genetic hypertension. Immature (1-week-old) and adult (12-week-old) normotensive Wistar-Kyoto (WKY) and spontaneously hypertensive kidney rats (SHR) were used for quantif...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(94)00150-5
更新日期：1995-01-01 00:00:00
abstract：:Diapause pupae of the swallowtail butterfly Papilio xuthus L. exhibit diapause-green, orange and brownish-orange color polymorphism. Development of orange pupae involves a neuroendocrine factor inducing orange pupa (Orange-Pupa-Inducing Factor, OPIF), which is secreted from the head-thoracic region during late pharate...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2005.06.025
更新日期：2006-03-01 00:00:00
abstract：:This review is part of a special issue dedicated to Opioid addiction, and examines the influential role of opioid peptides, opioid receptors and opiate drugs in mediating food intake and body weight control in rodents. This review postulates that opioid mediation of food intake was an example of "positive addictive" p...
journal_title：Peptides
pub_type： 杂志文章,评审
doi：10.1016/j.peptides.2019.04.008
更新日期：2019-06-01 00:00:00
abstract：:Liver-expressed antimicrobial peptide 2 (LEAP-2) is a 40-residue cationic peptide originally purified from human blood ultrafiltrate. The native peptide contains two disulfide bonds and is unique regarding its primary structure. Its biological role is not known but a previous study showed that chemically synthesized L...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2009.10.006
更新日期：2010-01-01 00:00:00
abstract：:Trefoil factors (TFFs) 1, 2 and 3 are small polypeptides that are co-secreted with mucin throughout the body. They are up-regulated in cancer and inflammatory processes in the gastrointestinal system, where they are proposed to be involved in tissue regeneration, proliferation and protection. Our aim was to explore th...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2014.09.026
更新日期：2015-01-01 00:00:00
abstract：:Endothelin-1 may contribute to bronchial smooth muscle constriction and airway remodelling in asthma, where bronchial epithelial cells represent an important source of this peptide. We report here that asthmatic bronchial epithelial cells exposed to allergens in vitro induce the differentiation of airway fibroblasts i...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/s0196-9781(97)00194-0
更新日期：1997-01-01 00:00:00
abstract：:Pituitary adenylate cyclase-activating peptide (PACAP) is a neuropeptide with strong bronchodilator capacity, present in the human airways. There is recent evidence that PACAP decreases the release of proinflammatory cytokines. We have previously shown that PACAP inhibits neutrophil chemotaxis, but altogether little i...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/s0196-9781(02)00149-3
更新日期：2002-10-01 00:00:00
abstract：:Mussels have diverse groups of cysteine rich, cationic antimicrobial peptides (AMPs) (defensins, mytilins, myticins, and mytimycin) that constitute an important component of their innate immune defence. Despite the identification and characterization of these AMPs in mussels, the underlying genetic mechanisms that mai...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2008.03.007
更新日期：2008-07-01 00:00:00
abstract：:The effects of dipeptide cyclo-[His-Pro] (CHP), known to participate in the appetite behavior and food intake control, have been investigated using PC12 cells in culture as model system. We found that only in the presence of experimental conditions that cause cellular stress the cyclic dipeptide affect cellular prolif...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2005.07.010
更新日期：2006-01-01 00:00:00
abstract：:We screened nearly 1000 synthetic peptides and found that JAL-AK22 (KYEGHWYPEKPYKGSGFRCIHI), which is derived from the BoxA domain in the Tob1 protein, activates both unfolded and folded proMMP-7. Interestingly, the smaller derivative of JAL-AK22, termed JAL-TA9 (YKGSGFRMI) possessed auto-proteolytic activity and clea...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2019.03.005
更新日期：2019-06-01 00:00:00
abstract：:To determine the functional role for and the pharmacological specificity of developing gastrointestinal CCK receptors, in vitro pyloric contractility and autoradiographic CCK receptor binding were examined in pups aged 1-20 days. CCK contracted the gastroduodenal junction at all ages, while nonsulfated CCK-8 (d-CCK) w...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(90)90152-u
更新日期：1990-11-01 00:00:00
abstract：:As the frequent emergence of the resistant bacteria, the development of new agents with a new action mode attracts a great deal of interest. It is now widely accepted that antimicrobial peptides (AMPs) are promising alternatives to conventional antibiotics. In this study, antimicrobial peptide polybia-MPI and its anal...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2012.11.002
更新日期：2013-01-01 00:00:00
abstract：:Members of the neprilysin family of neutral endopeptidases (M13) are typically membrane-bound enzymes known to be involved in the extra-cellular metabolism of signalling peptides and have important roles during mammalian embryogenesis. In this study we show that membranes prepared from embryos of Drosophila melanogast...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2006.08.032
更新日期：2007-01-01 00:00:00
abstract：:Although a great deal is published on the MCH neurons, very few works were devoted to the study of their development. However, existing literature points out two important traits: first, these neurons differentiate a MCH phenotype very early in all species studied so far, which might suggest a role for the MCH peptide...
journal_title：Peptides
pub_type： 杂志文章,评审
doi：10.1016/j.peptides.2009.07.016
更新日期：2009-11-01 00:00:00
abstract：:A newly developed system of isolated rat colonic epithelial cells was utilized for a comprehensive study of protein synthesis influenced by gastrin. We found that synthetic human gastrin (0.01-100 nM) increased the incorporation of [35S]methionine into proteins within 2 hours. Peak incorporation was observed with 10 n...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(91)90168-o
更新日期：1991-01-01 00:00:00
abstract：:Phalloidin staining F-actin was used to image muscle fiber arrangements present in the reproductive system of the adult female Rhodnius prolixus. A mesh of muscle fibers encircles the ovaries whereas a criss-cross pattern of finer muscle fibers covers each ovariole. Two layers of muscle fibers (arranged longitudinally...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2013.04.003
更新日期：2014-03-01 00:00:00
abstract：:The prothoracicotropic hormones (PTTH) are cerebral peptides that control insect postembryonic development by stimulating the prothoracic glands to synthesize ecdysteroids. Using immunoaffinity chromatography and SDS-PAGE, a 25.5 kDa big PTTH has been purified from Manduca sexta. Based upon SDS-PAGE and Western blot a...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(93)90142-4
更新日期：1993-05-01 00:00:00
abstract：:Somatostatin is reported in a new population of human sweat duct cells. The epithelial content of somatostatin-like immunoreactivity in normal human skin from various sites of the body was investigated using indirect immunofluorescence. With this methodology we found round-to-oval somatostatin-immunoreactive cells sit...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(93)90058-o
更新日期：1993-03-01 00:00:00
abstract：:Glucagon is a peptide hormone secreted from the pancreatic alpha cells in response to hypoglycemia but in some patients with type 2 diabetes a paradoxical hypersecretion results from the intake of glucose. In rodent, antagonizing the actions of glucagon have been shown to be effective for lowering blood glucose levels...
journal_title：Peptides
pub_type： 杂志文章,评审
doi：10.1016/j.peptides.2017.11.016
更新日期：2018-02-01 00:00:00
abstract：:Originally characterized in terms of its gastric acid inhibitory properties, GIP (gastric inhibitory polypeptide) expressed in the upper small intestine, was subsequently shown to exert strong glucose-dependent insulin-releasing properties. This action is generally attributed to GIP(1-42) and, so far, no evidence for ...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(95)00090-7
更新日期：1995-01-01 00:00:00
abstract：:Atriopeptins are circulating peptide hormones which are secreted by atrial tissue and act at the kidney. Because the atriopeptins survive passage through the pulmonary circulation, they also may be involved in the modulation of airway or pulmonary vascular smooth muscle tone. Using in vitro organ bath techniques, atri...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(85)90159-7
更新日期：1985-07-01 00:00:00
abstract：:In recent years our knowledge of the nervous control of the cerebral circulation has increased. The use of denervations and retrograde tracing in combination with immunohistochemical techniques has demonstrated that cerebral vessels are supplied with sympathetic, parasympathetic, and sensory nerve fibers and possibly ...
journal_title：Peptides
pub_type： 杂志文章,评审
doi：10.1016/s0196-9781(01)00408-9
更新日期：2001-06-01 00:00:00
abstract：:Calcification-associated peptide (CAP)-1 is considered to play an important role in calcification of the exoskeleton of the crayfish, Procambarus clarkii. In this study, in order to clarify the molecular mechanism of calcification, we constructed expression systems of recombinant molecules of CAP-1 and its related pep...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2006.12.005
更新日期：2007-03-01 00:00:00
abstract：:Spinal cords of rats, cats and monkeys were transected; the animals were perfused at varying times. Other rats were injected with morphine and perfused 10 days later. Immunocytochemistry shows substance P (SP) present in control animals primarily in the substantia gelatinosa (SG) of the dorsal horn of the spinal cord....
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(81)90057-7
更新日期：1981-01-01 00:00:00
abstract：:Receptors for neuropeptide Y (NPY) and peptide YY (PYY) have been extensively characterized in the brain. Less is known about NPY receptor subtypes in the spleen, though it is well established that NPY produces vascular contraction in this tissue. In the present study, we found an unusually high density of Y1 receptor...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/s0196-9781(96)00228-8
更新日期：1996-01-01 00:00:00
abstract：:VIP receptors on blood mononuclear leucocytes and plasma VIP concentrations were studied during a ranger training course lasting for five days with almost continuous physical activity, and energy deficiency. The maximum binding capacity (Bmax) for the high affinity receptor increased (p less than 0.0005) from 0.71 (SE...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(88)90025-3
更新日期：1988-01-01 00:00:00
abstract：:A method has been developed for the study of somatostatin (SS) binding to dissociated cells from rat cerebral cortex. Binding of [125I] [Tyr11]SS to cells obtained by mechanical dissociation of rat cerebral cortex was dependent on time and temperature, saturable, reversible and highly specific. Under conditions of equ...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(90)90138-u
更新日期：1990-11-01 00:00:00
abstract：:The purpose of this study is to elucidate the mechanism of action and site of action of calcitonin gene-related peptide (CGRP) and its effects on calcium concentrations in two types of cardiomyocytes, neonatal and adult, by employing real-time fluorescence imaging. CGRP caused an increase in intramyocytic calcium with...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2005.04.021
更新日期：2005-11-01 00:00:00
abstract：:The effects of third ventricular (IVT) injection of 25 micrograms of bradykinin (BK) upon plasma levels of LH, FSH, TSH, GH and prolactin were investigated in conscious ovariectomized female rats bearing indwelling jugular cannulae. Some animals were pretreated with bradykinin potentiating factor (BPF). Intravenous ad...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(80)90054-6
更新日期：1980-10-01 00:00:00
abstract：:A novel antimicrobial peptide, with molecular mass of 1602.0469Da, produced by Brevibacillus laterosporus strain A60 was isolated and purified from the soil of mango plants. The purification procedure consisted of ammonium sulfate precipitation, cation exchange chromatography on an HiTrap SP HP column, thin layer chro...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2012.01.001
更新日期：2012-02-01 00:00:00
