Abstract:
:Trefoil factors (TFFs) 1, 2 and 3 are small polypeptides that are co-secreted with mucin throughout the body. They are up-regulated in cancer and inflammatory processes in the gastrointestinal system, where they are proposed to be involved in tissue regeneration, proliferation and protection. Our aim was to explore their presence in pulmonary secretions and to investigate whether they are up-regulated in pulmonary diseases characterized by mucin hypersecretion. Bronchioalveolar lavage fluid was obtained from 92 individuals referred to bronchoscopy. The patients were grouped according to diagnosis and pulmonary function. The concentrations of TFF1, TFF2 and TFF3 were measured by ELISA. All three peptides were detected in bronchioalveolar lavage fluid. Patients with chronic obstructive pulmonary disease had concentrations two to three times above the levels in the healthy reference group, and patients with pulmonary malignancies had concentrations of TFF1 and TFF2 three times that of the reference group. The results suggest that TFFs are involved in tissue regeneration, proliferation and protection in lung diseases.
journal_name
Peptidesjournal_title
Peptidesauthors
Viby NE,Nexø E,Kissow H,Andreassen H,Clementsen P,Thim L,Poulsen SSdoi
10.1016/j.peptides.2014.09.026subject
Has Abstractpub_date
2015-01-01 00:00:00pages
90-5eissn
0196-9781issn
1873-5169pii
S0196-9781(14)00297-6journal_volume
63pub_type
杂志文章相关文献
PEPTIDES文献大全abstract::A neuropeptide F (NPF) was isolated from the fruit fly, Drosophila mellanogaster, based on a radioimmunoassay for a gut peptide from the corn earworm, Helicoverpa zea. A partial sequence was obtained from the fly peptide, and a genomic sequence coding for NPF was cloned after inverse polymerase chain reaction and show...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(99)00097-2
更新日期:1999-01-01 00:00:00
abstract::The very first step in the study of the endocrine control of insect molting was taken in 1922. Stefan Kopec characterized a factor in the brain of the gypsy moth, Lymantria dispar which appeared to be essential for metamorphosis. This factor was later identified as the neuropeptide prothoracicotropic hormone (PTTH), t...
journal_title:Peptides
pub_type: 杂志文章,评审
doi:10.1016/j.peptides.2009.08.020
更新日期:2010-03-01 00:00:00
abstract::To study the effects of inducing stereo-chemical modifications in the structure of dermorphin (DM) so as to improve its mu-opioid receptor affinity and its resistance to C-terminal enzymatic degradation, in the Institute of Molecular Genetics of Moscow, we synthesized a new DM analogue ([DPro(6)]DM) and analyzed the c...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(03)00057-3
更新日期:2003-03-01 00:00:00
abstract::This paper reports the purification and biochemical/pharmacological characterization of two myotoxic phospholipases A(2) (PLA(2)s) from Bothrops brazili venom, a native snake from Brazil. Both myotoxins (MTX-I and II) were purified by a single chromatographic step on a CM-Sepharose ion-exchange column up to a high pur...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2008.05.021
更新日期:2008-10-01 00:00:00
abstract::Female Zucker lean and obese rats were treated for 14 days with 3.5 micromol/kg oleoyl-estrone (OE) in liposomes (Merlin-2). After 0, 3, 6, 10, and 14 days of treatment, the rats were killed and hypothalamic nuclei (lateral preoptic, median preoptic, paraventricular, ventromedial and arcuate) were used for neuropeptid...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(98)00104-1
更新日期:1998-01-01 00:00:00
abstract::Melanin-concentrating hormone (MCH) has attracted considerable attention because of its effects on food intake and body weight and the MCH receptor (MCHR1) remains one of the viable targets for obesity therapy. This review summarizes the literature examining the effects of MCH on body weight, food intake and energy ex...
journal_title:Peptides
pub_type: 杂志文章,评审
doi:10.1016/j.peptides.2009.05.002
更新日期:2009-11-01 00:00:00
abstract::The actions of a behaviorally active luteinizing hormone-releasing hormone fragment, Ac-LHRH(5-10), on CA1 pyramidal cells were studied utilizing conventional intracellular recordings from the in vitro rat hippocampal slice preparation. The behaviorally active fragment (10(-7) M) and the natural decapeptide [LHRH(1-10...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(93)90090-4
更新日期:1993-09-01 00:00:00
abstract::The present study investigated the effects of neuropeptide Y (NPY) on food intake and body temperature (Tbo) in free-feeding unrestrained rats following injection into the medial hypothalamic paraventricular nucleus (PVN) or the lateral perifornical hypothalamus (PFH). NPY (78-235 pmol) or saline was infused unilatera...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(95)00020-k
更新日期:1995-01-01 00:00:00
abstract::Parathyroid hormone (PTH) has been shown to have actions within the brain, suggesting the presence of central PTH receptors. This possibility was examined by determining the binding of 125I-labeled [Nle8,18,Tyr34]bovine PTH to the plasma membranes of rat and rabbit brains. Specific binding of the tracer to membranes o...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(93)90174-f
更新日期:1993-11-01 00:00:00
abstract::Antibiotic therapy for methicillin-resistant Staphylococcus aureus (MRSA) infections is becoming more difficult in hospitals and communities because of strong biofilm-forming properties and multidrug resistance. Biofilm-associated MRSA is not affected by therapeutically achievable concentrations of antibiotics. Theref...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2013.08.008
更新日期:2013-11-01 00:00:00
abstract::A lectin was isolated from extracts of fruiting bodies of the mushroom Xerocomus spadiceus using a procedure that involved ion exchange chromatography on DEAE-cellulose, affinity chromatography on Affi-gel blue gel, ion exchange chromatography on CM-cellulose, and gel filtration by fast protein liquid chromatography o...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2003.11.013
更新日期:2004-01-01 00:00:00
abstract::Bradykinin-potentiating peptides from Bothrops jararaca (Bj) discovered in the early 1960s, were the first natural inhibitors of the angiotensin-converting enzyme (ACE). These peptides belong to a large family of snake venom proline-rich oligopeptides (PROs). One of these peptides, Bj-PRO-9a, was essential for definin...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2013.07.016
更新日期:2013-10-01 00:00:00
abstract::We are interested in the presence and function in insects of neuropeptides related to the vertebrate tachykinins. Hence, we have used antisera raised against the tachykinins substance P and kassinin, and against the insect neuropeptide leucokinin I, for localization studies and immunochemical analysis of related pepti...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(93)90094-w
更新日期:1993-07-01 00:00:00
abstract::Male Holtzman albino and Long-Evans hooded rats were administered one microgram of arginine vasopressin (AVP) or a placebo each day after the acquisition trials of a visual white-black discrimination. Animals were then trained in the reversal of the discrimination. Performance was assessed by the number of trials to c...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(89)90099-5
更新日期:1989-01-01 00:00:00
abstract::Neuropeptide FF (NPFF) has certain antiopiate actions and may play a role in opiate tolerance and dependence. Third ventricle injection of 10 micrograms NPFF induces a quasimorphine abstinence syndrome in opiate-naive rats. Nitric oxide synthesis may also contribute to opiate tolerance and dependence. The present stud...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(96)00035-6
更新日期:1996-01-01 00:00:00
abstract::Strips of lower esophageal sphincter (LES) from rabbits were tested for their responses to several peptides, and to electrical field stimulation (EFS) under the presence of some peptides. Substance P (SP), motilin, and bombesin induced contraction, and vasoactive intestinal peptide (VIP) induced relaxation. SP- and bo...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(96)00137-4
更新日期:1996-01-01 00:00:00
abstract::Orexin (ORX) plays a critical role in reward-seeking behavior for natural rewards and drugs of abuse. The mesolimbic dopamine (DA) pathway that projects into the nucleus accumbens (NAc) from the ventral tegmental area is deeply involved in the neural mechanisms underlying reward, drug abuse and motivation. A recent st...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2010.10.023
更新日期:2011-02-01 00:00:00
abstract::Discovering the informational rule(s) underlying structure-function relationships in the protein language is at the core of biology. Current theories have proven inadequate to explain the origins of biological information such as that found in nucleotide and amino acid sequences. Here, we demonstrate that the informat...
journal_title:Peptides
pub_type: 杂志文章,评审
doi:10.1016/j.peptides.2010.02.003
更新日期:2010-05-01 00:00:00
abstract::Pacifastin-like protease inhibitors belong to a recent classified protease inhibitor family and they are the smallest protease inhibitors described in animals. In this work, we purified and characterized, for the first time, two neutrophil elastase inhibitors belonging to the pacifastin family from the blood sucking i...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2010.03.033
更新日期:2010-07-01 00:00:00
abstract::Recently, a new serine protease inhibitor family has been described in arthropods. Eight members were purified from locusts and 13 peptides have been identified by cDNA cloning. The peptides share a conserved cysteine array (Cys-Xaa(9-12)-Cys-Asn-Xaa-Cys-Xaa-Cys-Xaa(2-3)-Gly-Xaa(3-6)-Cys-Thr-Xaa(3)-Cys) with nine inhi...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2004.03.005
更新日期:2004-06-01 00:00:00
abstract::As an attempt to approach the pathogenesis of peptic ulcer disease, antral gastrin and somatostatin concentrations were studied in normal subjects, patients with duodenal ulcer and gastric ulcer. In the patients with peptic ulcer, antral somatostatin concentrations were significantly lower than those in normal subject...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(81)90046-2
更新日期:1981-01-01 00:00:00
abstract::We screened nearly 1000 synthetic peptides and found that JAL-AK22 (KYEGHWYPEKPYKGSGFRCIHI), which is derived from the BoxA domain in the Tob1 protein, activates both unfolded and folded proMMP-7. Interestingly, the smaller derivative of JAL-AK22, termed JAL-TA9 (YKGSGFRMI) possessed auto-proteolytic activity and clea...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2019.03.005
更新日期:2019-06-01 00:00:00
abstract::Previously, calcitonin gene-related peptide (CGRP) decreased food intake when administered ICV but not when administered peripherally to rats. Amylin, which has a close structural homology to CGRP, reduced food intake administered IP at concentrations higher than those previously tested for CGRP. We examined the effec...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(96)00015-0
更新日期:1996-01-01 00:00:00
abstract::We have evaluated a new immunoradiometric assay (IRMA) for calcitonin (CT) (Medgenix, Belgium). The detection limit of immunoreactive CT (IR-CT) was 2.8 pg/ml, and plasma levels of IR-CT of 134 healthy adults (dynamic range, 2.8-1000 pg/ml) were < 19 pg/ml (median 4.1 pg/ml). Both basal and pentagastrin-stimulated IR-...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(94)00177-4
更新日期:1995-01-01 00:00:00
abstract::The present study purifies two T. serrulatus non-disulfide-bridged peptides (NDBPs), named venom peptides 7.2 (RLRSKG) and 8 (KIWRS) and details their synthesis and biological activity, comparing to the synthetic venom peptide 7.1 (RLRSKGKK), previously identified. The synthetic replicate peptides were subjected to a ...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2016.05.008
更新日期:2016-08-01 00:00:00
abstract::Recently two hypothalamic releasing factors have been isolated, sequenced and synthesized: corticotropin-releasing factor (CRF) from sheep and rat hypothalami; and growth hormone-releasing factor (GH-RF) from tumors in human pancreas (hpGH-RF) and from rat hypothalami (rhGH-RF). Their biological potencies were tested ...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(84)90282-1
更新日期:1984-01-01 00:00:00
abstract::In this study we investigated the role that dopaminergic pathways play in the miotic effect exerted by neurotensin after intracameral administration. Neurotensin was injected into the anterior chamber (AC) at a dose of 30 micrograms to 4 groups of albino rabbits which had previously undergone the following treatment: ...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(90)90165-2
更新日期:1990-11-01 00:00:00
abstract::Pharmacological study of Phe-Met-Leu-Phe-amide (FMRFa) receptors is hindered by the lack of selective ligands. The classification of these selective ligands is further hampered by the limited availability of functional assays. In this study, we evaluated several synthetic FMRFa analogs for agonist and antagonist activ...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(97)00481-6
更新日期:1998-01-01 00:00:00
abstract::The first member of the periviscerokinin peptide family in Locusta migratoria was identified by post-source decay fragmentation on a MALDI-TOF mass spectrometer using a single neurohemal organ only. The primary sequence of this decapeptide, code-named Lom-PVK, is Ala-Ala-Gly-Leu-Phe-Gln-Phe-Pro-Arg-Val-NH(2). Unlike t...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(01)00669-6
更新日期:2002-04-01 00:00:00
abstract::A novel protein expressed by entero-endocrine cells of the mouse stomach was named prepromotilin Related Peptide (ppMTLRP) since it shares sequence similarities with the prepromotilin (Tomasetto et al.). The mouse ppMTLRP was found identical to the rat precursor of ghrelin (ppghrelin), an endogenous ligand specific fo...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(01)00557-5
更新日期:2001-12-01 00:00:00