Neurotensin-induced miosis: the role of dopaminergic pathways.

Abstract:

:In this study we investigated the role that dopaminergic pathways play in the miotic effect exerted by neurotensin after intracameral administration. Neurotensin was injected into the anterior chamber (AC) at a dose of 30 micrograms to 4 groups of albino rabbits which had previously undergone the following treatment: a) desmethylimipramine IM and, after 30 min, 6-hydroxydopamine IV 7 days prior to the neurotensin administration; b) haloperidol IM for 15 days; c) haloperidol AC 10 minutes before the neurotensin administration. Our data confirm previous observations regarding the miotic activity of neurotensin and suggest that the dopaminergic system plays an important role in the miotic effect of neurotensin.

journal_name

Peptides

journal_title

Peptides

authors

Tassorelli C,Spampinato D,Caruso P,Cavaliere S,Micieli G,Drago F,Nappi G

doi

10.1016/0196-9781(90)90165-2

subject

Has Abstract

pub_date

1990-11-01 00:00:00

pages

1309-11

issue

6

eissn

0196-9781

issn

1873-5169

pii

0196-9781(90)90165-2

journal_volume

11

pub_type

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