Abstract:
:Previously, calcitonin gene-related peptide (CGRP) decreased food intake when administered ICV but not when administered peripherally to rats. Amylin, which has a close structural homology to CGRP, reduced food intake administered IP at concentrations higher than those previously tested for CGRP. We examined the effects of higher doses of IP-administered CGRP on food intake. CGRP reduced food intake from 25 to 200 micrograms/kg in mice. CGRP did not reduce water intake and was not aversive in a two-bottle test. Using a lever press, CGRP was more effective at reducing milk consumption in prefed than in nonprefed mice. The effect of CGRP on food intake was not antagonized by the cholecystokinin A receptor antagonist, L364,718. These studies suggest a role for CGRP as a satiating factor.
journal_name
Peptidesjournal_title
Peptidesauthors
Morley JE,Farr SA,Flood JFdoi
10.1016/0196-9781(96)00015-0subject
Has Abstractpub_date
1996-01-01 00:00:00pages
511-6issue
3eissn
0196-9781issn
1873-5169pii
0196-9781(96)00015-0journal_volume
17pub_type
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