Abstract:
:Dissociated muscle cells prepared from hearts of the pulmonate snail Helix aspersa were used to study signal transduction induced by molluscan cardioactive peptides. The effects of SCPb on the cAMP levels of whole hearts and the cell preparation were compared. The cells responded to SCPb with a dose-dependent increase in cAMP that had the same structure-activity relations as seen in the intact tissue. SCPb increased the phosphorylation of a 53 kDa protein in a dose dependent manner; threshold was 10(-9) M. The SCPb-induced phosphorylation was mimicked by forskolin and 8-CPT-cAMP. FMRFamide stimulation had no effect on the phosphorylation of this protein.
journal_name
Peptidesjournal_title
Peptidesauthors
Reich G,Doble KE,Greenberg MJdoi
10.1016/s0196-9781(97)00196-4subject
Has Abstractpub_date
1997-01-01 00:00:00pages
1311-4issue
9eissn
0196-9781issn
1873-5169pii
S0196-9781(97)00196-4journal_volume
18pub_type
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