Protein phosphorylation in snail cardiocytes stimulated with molluscan peptide SCPb.

Abstract:

:Dissociated muscle cells prepared from hearts of the pulmonate snail Helix aspersa were used to study signal transduction induced by molluscan cardioactive peptides. The effects of SCPb on the cAMP levels of whole hearts and the cell preparation were compared. The cells responded to SCPb with a dose-dependent increase in cAMP that had the same structure-activity relations as seen in the intact tissue. SCPb increased the phosphorylation of a 53 kDa protein in a dose dependent manner; threshold was 10(-9) M. The SCPb-induced phosphorylation was mimicked by forskolin and 8-CPT-cAMP. FMRFamide stimulation had no effect on the phosphorylation of this protein.

journal_name

Peptides

journal_title

Peptides

authors

Reich G,Doble KE,Greenberg MJ

doi

10.1016/s0196-9781(97)00196-4

subject

Has Abstract

pub_date

1997-01-01 00:00:00

pages

1311-4

issue

9

eissn

0196-9781

issn

1873-5169

pii

S0196-9781(97)00196-4

journal_volume

18

pub_type

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