Abstract:
:The role of neuropeptides in cardiomyopathy-associated heart failure has been garnering more attention. Several neuropeptides--Neuropeptide Y (NPY), vasoactive intestinal peptide (VIP), calcitonin gene related peptide (CGRP), substance P (SP) and their receptors have been studied in the various types of cardiomyopathies. The data indicate associations with the strength of the association varying depending on the kind of neuropeptide and the nature of the cardiomyopathy--diabetic, ischemic, inflammatory, stress-induced or restrictive cardiomyopathy. Several neuropeptides appear to alter regulation of genes involved in heart failure. Demonstration of an association is an essential first step in proving causality or establishing a role for a factor in a disease. Understanding the complexity of neuropeptide function should be helpful in establishing new or optimal therapeutic strategies for the treatment of heart failure in cardiomyopathies.
journal_name
Peptidesjournal_title
Peptidesauthors
Dvorakova MC,Kruzliak P,Rabkin SWdoi
10.1016/j.peptides.2014.08.004subject
Has Abstractpub_date
2014-11-01 00:00:00pages
1-6eissn
0196-9781issn
1873-5169pii
S0196-9781(14)00242-3journal_volume
61pub_type
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