The development of the MCH system.

abstract：:In the present study we used intracerebral microdialysis techniques to examine whether angiotensin II (ANG II) modulates the release of serotonin (5-hydroxytryptamine, 5-HT) in the subfornical organ (SFO) in freely moving rats. Extracellular concentrations of 5-HT and its metabolite 5-hydroxyindoleacetic acid (5-HIAA)...

journal_title：Peptides

authors： Tanaka J,Kariya K,Nomura M

更新日期：2003-06-01 00:00:00

abstract：:Gastrin-releasing peptide (GRP) has been implicated in the itch-scratch cycle. We investigated if this gut-brain-skin peptide plays a role in the compulsive, hindleg scratching of the neck of mice by 5'-guanidinonaltrindole (GNTI), the kappa opioid receptor antagonist, and in the antipruritic activity of nalfurafine, ...

journal_title：Peptides

authors： Inan S,Dun NJ,Cowan A

更新日期：2011-02-01 00:00:00

abstract：:Antimicrobial peptides (AMPs) secreted by amphibian skin represent an important innate immune defense strategy. There are more than 340 species in the family of Ranidae worldwidely, and from which nearly 100 families of AMPs comprising between 8 and 48 amino acid (aa) residues have been characterized. In current work,...

journal_title：Peptides

authors： Zhang S,Guo H,Shi F,Wang H,Li L,Jiao X,Wang Y,Yu H

更新日期：2012-02-01 00:00:00

abstract：:Recently, a new serine protease inhibitor family has been described in arthropods. Eight members were purified from locusts and 13 peptides have been identified by cDNA cloning. The peptides share a conserved cysteine array (Cys-Xaa(9-12)-Cys-Asn-Xaa-Cys-Xaa-Cys-Xaa(2-3)-Gly-Xaa(3-6)-Cys-Thr-Xaa(3)-Cys) with nine inhi...

journal_title：Peptides

authors： Simonet G,Claeys I,Van Soest S,Breugelmans B,Franssens V,De Loof A,Vanden Broeck J

更新日期：2004-06-01 00:00:00

abstract：:Concentrations of immunoreactive galanin were compared in eight gross brain regions of ovariectomized female rats treated with either estradiol, estradiol + progesterone, estradiol + norethisterone, or placebo. Higher concentrations with estradiol treatment compared with placebo were found in the pituitary (357%), fro...

journal_title：Peptides

authors： Rugarn O,Theodorsson A,Hammar M,Theodorsson E

更新日期：1999-01-01 00:00:00

abstract：:Motilin-immunopositive cells (Mo cells) are known to be present in the upper small intestine of various species, including man. However, whether Mo cells are present in the rabbit gastrointestinal tract remained to be elucidated. Therefore, this study was designed to investigate the distribution of Mo cells in the rab...

journal_title：Peptides

authors： Satoh M,Sakai T,Koyama H,Shiba Y,Itoh Z

更新日期：1995-01-01 00:00:00

abstract：:The present study purifies two T. serrulatus non-disulfide-bridged peptides (NDBPs), named venom peptides 7.2 (RLRSKG) and 8 (KIWRS) and details their synthesis and biological activity, comparing to the synthetic venom peptide 7.1 (RLRSKGKK), previously identified. The synthetic replicate peptides were subjected to a ...

journal_title：Peptides

authors： Pucca MB,Cerni FA,Pinheiro-Junior EL,Zoccal KF,Bordon KCF,Amorim FG,Peigneur S,Vriens K,Thevissen K,Cammue BPA,Júnior RBM,Arruda E,Faccioli LH,Tytgat J,Arantes EC

更新日期：2016-08-01 00:00:00

abstract：:Cocaine- and amphetamine-regulated transcript (CART) is a neurotransmitter and hormone, involved in the regulation of e.g. food intake, body weight, reward and addiction, and stress response. CART has also been found to affect insulin secretion and beta cell morphology, both in vivo and in vitro. Furthermore, CART aff...

journal_title：Peptides

authors： Drott CJ,Norman D,Espes D

更新日期：2021-01-01 00:00:00

abstract：:Neuropeptide FF (NPFF) has been shown to act as an endogenous anti-analgesic peptide. In this paper, several peptide analogs of the selective ligand dNP(NMe)AFLFQPQRF-NH(2) modified in the putative address segment, were designed to be selective NPFF(2) receptor probes, synthesized and assayed. One peptide dA(NMe)AAFLF...

journal_title：Peptides

authors： Mazarguil H,Mollereau C,Czaplicki G,Zajac JM

更新日期：2012-09-01 00:00:00

abstract：:The anorectic effect of IP injection of amylin (1 microgram/kg) was abolished by simultaneous IP injection of the amylin receptor antagonist calcitonin gene-related peptide-(8-37) [CGRP(8-37), 10 micrograms/kg]. The IP injection of pancreatic glucagon (400 micrograms/kg) at dark onset also reduced food intake in 24-h ...

journal_title：Peptides

authors： Lutz TA,Del Prete E,Szabady MM,Scharrer E

更新日期：1996-01-01 00:00:00

abstract：:Low-density lipoprotein (LDL) concentrations have been linked to altered responses to endogenous vasodilators and vasoconstrictors. We evaluated retrospectively the relationship between LDL and vasoconstrictor (endothelin-1, phenylephrine) responsiveness of the forearm vasculature in 15 elderly healthy volunteers with...

journal_title：Peptides

authors： Romerio SC,Linder L,Flammer J,Haefeli WE

更新日期：2000-06-01 00:00:00

abstract：:Tardive dyskinesia, a clinical syndrome, is one of the major side effects of protracted treatment with neuroleptics in schizophrenic patients. Functional supersensitivity of striatal dopamine receptors is believed to contribute to the pathogenesis of schizophrenia and tardive dyskinesia. In a rodent model of neurolept...

journal_title：Peptides

authors： Rajakumar G,Naas F,Johnson RL,Chiu S,Yu KL,Mishra RK

更新日期：1987-09-01 00:00:00

abstract：:In situ hybridization techniques have been developed that quantitate the relative levels of specific mRNAs in individual cell types of a heterogeneous tissue, the mammalian brain. Here, we discuss those special procedures and precautions necessary for hybridizing radiolabeled probes to developing and adult brain mRNAs...

journal_title：Peptides

authors： Griffin WS,Morrison MR

更新日期：1985-01-01 00:00:00

abstract：:In order to elucidate the relationship between secretory pathway and processing for precursor molecule of peptide hormones, we performed immunoelectron microscopic studies to localize POMC-derived peptides in mouse cultured L cells (fibroblasts without secretory granules) and in mouse AtT20 cells (ACTH secreting pitui...

journal_title：Peptides

authors： Osamura RY,Suemizu Y,Yoshimura S,Hori S,Inada K,Watanabe K,Nakai Y,Imura H

更新日期：1991-05-01 00:00:00

abstract：:Cholecystokinin octapeptides (CCK8s) have been purified from methanol extracts of two brains from each of two Australian marsupials, Tammar Wallaby and Eastern Quoll, containing 3 nmol and 2 nmol of the peptides, respectively. Immunoreactive CCK was concentrated on QMA SepPak cartridges and purified by two successive ...

journal_title：Peptides

authors： Fan ZW,Eng J,Shaw G,Yalow RS

更新日期：1988-03-01 00:00:00

abstract：:Neuropeptide S (NPS), the endogenous ligand of NPS receptor (NPSR), regulates many biological functions, including arousal, anxiety, locomotion and food intake. NPSR mRNA is expressed in several regions of central autonomic network through which the brain controls visceromotor and other responses essential for surviva...

journal_title：Peptides

authors： Han RW,Chang M,Peng YL,Qiao LY,Yin XQ,Li W,Wang R

更新日期：2009-07-01 00:00:00

abstract：:Just as the blood-brain barrier (BBB) is not a static barrier, the adipocytes are not inert storage depots. Adipokines are peptides or polypeptides produced by white adipose tissue; they play important roles in normal physiology as well as in the metabolic syndrome. Adipokines secreted into the circulation can interac...

journal_title：Peptides

authors： Pan W,Kastin AJ

更新日期：2007-06-01 00:00:00

abstract：:Hypocretin-1 (hcrt-1) and hypocretin-2 (hcrt-2) are two recently discovered hypothalamic neuropeptides. In the present study, using double immunofluorescent techniques, the co-localization of hcrt-1 and hcrt-2 was examined in neuronal soma and fibers/terminals located, respectively, in the cat hypothalamus and brainst...

journal_title：Peptides

authors： Zhang JH,Sampogna S,Morales FR,Chase MH

更新日期：2002-08-01 00:00:00

abstract：:Rhesus monkey MCH-R1 and MCH-R2 receptors were cloned. Amino acid homology is 98.8% between monkey and human MCH-R1, while monkey and human MCH-R2 are 98% homologous. Binding and intracellular signaling characteristics of the monkey receptors were compared with the human homologues. The results demonstrate that MCH bi...

journal_title：Peptides

authors： Fried S,O'Neill K,Hawes BE

更新日期：2002-08-01 00:00:00

abstract：:Oxytocin receptors have recently been demonstrated in human osteoblast-like (hOB) cells. In this study, oxytocin 100-1000 pmol/l increased cell proliferation of primary cultures of hOB cells, measured by [3H]thymidine incorporation, (P<0.01). In human osteosarcoma cell-line (SaOS-2), oxytocin 100 pmol/l increased cell...

journal_title：Peptides

authors： Petersson M,Lagumdzija A,Stark A,Bucht E

更新日期：2002-06-01 00:00:00

abstract：:Various growth factors and their receptors are present in the nervous system. This review focuses on the presence of epidermal growth factor (EGF) and its receptors in the central nervous system (CNS). Evidence indicates that EGF in the CNS is the result of local synthesis, by intrinsic and blood-derived macrophages, ...

journal_title：Peptides

authors： Plata-Salamán CR

更新日期：1991-05-01 00:00:00

abstract：:We have developed a specific and sensitive radioimmunoassay for the hydra head activator neuropeptide (HHAP). The antibody recognizes the C-terminal portion of HHAP and shows no cross-reactivity with other neuropeptides. The assay allows measurement of HHAP-like material in tissue extracts with a minimum detectable co...

journal_title：Peptides

authors： Ekman R,Salford L,Brun A,Larsson I

更新日期：1990-03-01 00:00:00

abstract：:Cholecystokinin COOH-terminal octapeptide (CCK-8) produces a satiating effect in the rat and other animals upon peripheral administration. Although it has been demonstrated that the receptors which mediate this action are located in the periphery and are of the CCK-A subtype, their anatomical location has not been fir...

journal_title：Peptides

authors： Murphy RB,Smith GP,Schneider LH,Gibbs J

更新日期：1992-01-01 00:00:00

abstract：:A non-specific lipid transfer peptide (nsLTP) with antimicrobial activity was isolated from the mung bean (Phaseolus mungo) seeds. The procedure entailed aqueous extraction, ion exchange chromatography on CM-Sephadex and high performance liquid chromatography (HPLC) on POROS-HS-20. The peptide exhibited a molecular ma...

journal_title：Peptides

authors： Wang SY,Wu JH,Ng TB,Ye XY,Rao PF

更新日期：2004-08-01 00:00:00

abstract：:Angiotensin II (Ang II) uptake and transport across monolayers of bovine brain microvessel endothelial cells (BMECs) was demonstrated. Ang II transport was linear up to 2 h, saturable with a K(m) of 1.7 nM, and tended to be polarized with the apical-to-basolateral transport being greater. [3H]Ang II transport was foun...

journal_title：Peptides

authors： Rose JM,Audus KL

更新日期：1998-01-01 00:00:00

abstract：:Investigators studying the primary culprit responsible for Alzheimer disease have, for the past two decades, primarily focused on amyloid-beta (Abeta). Here, we put Abeta on trial and review evidence amassed by the prosecution that implicate Abeta and also consider arguments and evidence gathered by the defense team w...

journal_title：Peptides

authors： Rottkamp CA,Atwood CS,Joseph JA,Nunomura A,Perry G,Smith MA

更新日期：2002-07-01 00:00:00

abstract：:Substance P (SP) is known to be involved in processes related to learning and memory, fear, anxiety and stress. SP and NK1 receptors are localized in the hippocampus, a brain structure involved in learning and memory as well as emotional processes. As there is evidence for differential functions of the ventral (VH) an...

journal_title：Peptides

authors： Carvalho MC,Masson S,Brandão ML,de Souza Silva MA

更新日期：2008-07-01 00:00:00

abstract：:The beta-casein-derived octapeptide RINKKIEK is a noncompetitive inhibitor of soybean lipoxygenase (LOX). To investigate the molecular determinants for the enzyme-peptide interaction, a peptide library containing substitutional analogs of RINKKIEK was prepared by SPOT synthesis and analyzed for interaction with fluore...

journal_title：Peptides

authors： Schurink M,van Berkel WJ,Wichers HJ,Boeriu CG

更新日期：2007-12-01 00:00:00

abstract：:Cholecystokinin (CCK) and met-enkephalin (MEK) related peptides have been shown to alter feeding behavior subsequent to their injection into the peripheral circulation or directly into the brains of several species. To evaluate the potential role of endogenous brain pools of these peptides in feeding, groups of sheep ...

journal_title：Peptides

authors： Scallet AC,Della-Fera MA,Baile CA

更新日期：1985-09-01 00:00:00

abstract：:Prothymosin alpha (ProTα), a nuclear protein, plays multiple functions including cell survival. Most recently, we demonstrated that the active 30-amino acid peptide sequence/P30 (amino acids 49-78) in ProTα retains its substantial activity in neuroprotection in vitro and in vivo as well as in the inhibition of cerebra...

journal_title：Peptides

authors： Halder SK,Sugimoto J,Matsunaga H,Ueda H

更新日期：2013-05-01 00:00:00