Abstract:
:Oxytocin receptors have recently been demonstrated in human osteoblast-like (hOB) cells. In this study, oxytocin 100-1000 pmol/l increased cell proliferation of primary cultures of hOB cells, measured by [3H]thymidine incorporation, (P<0.01). In human osteosarcoma cell-line (SaOS-2), oxytocin 100 pmol/l increased cell proliferation (measured by [3H]thymidine incorporation and a commercially available kit) and protein synthesis ([3H]proline incorporation) (P<0.05). The increase in cell proliferation was abolished when SaOS-2 cells were incubated with an oxytocin antagonist and oxytocin. Oxytocin 100 pmol/l decreased interleukin-6 (IL-6) production of the hOB cells (23.4+/-1.96 versus 33.4+/-2.65 pg/well; P<0.001). These findings indicate that oxytocin may affect bone metabolism in humans.
journal_name
Peptidesjournal_title
Peptidesauthors
Petersson M,Lagumdzija A,Stark A,Bucht Edoi
10.1016/s0196-9781(02)00041-4subject
Has Abstractpub_date
2002-06-01 00:00:00pages
1121-6issue
6eissn
0196-9781issn
1873-5169pii
S0196978102000414journal_volume
23pub_type
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