Abstract：
:Glucagon-related peptides such as glucagon, glucagon-like peptide-1, and oxyntomodulin suppress food intake in mammals and birds. Recently, novel glucagon-like peptide (GCGL) was identified from chicken brain, and a comparatively high mRNA expression level of GCGL was detected in the hypothalamus. A number of studies suggest that the hypothalamus plays a critical role in the regulation of food intake in mammals and birds. In the present study, we investigated whether GCGL is involved in the central regulation of food intake in chicks. Male 8-day-old chicks (Gallus gallus) were used in all experiments. Intracerebroventricular administration of GCGL in chicks significantly suppressed food intake. Plasma glucose level was significantly decreased by GCGL, whereas plasma corticosterone level was not affected. Central administration of a corticotrophin-releasing factor (CRF) receptor antagonist, α-helical CRF, attenuated GCGL-suppressed food intake. It seems likely that CRF receptor is involved in the GCGL-induced anorexigenic pathway. All our findings suggest that GCGL functions as an anorexigenic peptide in the central nervous system of chicks.
journal_name
Peptidesjournal_title
Peptidesauthors
Honda K,Saneyasu T,Yamaguchi T,Shimatani T,Aoki K,Nakanishi K,Kamisoyama Hdoi
10.1016/j.peptides.2013.12.008subject
Has Abstractpub_date
2014-02-01 00:00:00pages
98-103eissn
0196-9781issn
1873-5169pii
S0196-9781(13)00415-4journal_volume
52pub_type
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