Adrenomedullin binds with high affinity, elevates cyclic AMP, and stimulates c-fos mRNA in C6 glioma cells.

abstract：:In experimental models and in humans, somatostatin (SRIF) is able to contract certain vascular structures. The present experiments were designed to assess the capacity of SRIF to contract cultured rat aortic vascular smooth muscle cells (VSMC), and to analyze the possible mechanisms involved. Cells incubated with SRIF...

journal_title：Peptides

authors： Torrecillas G,Medina J,Díez-Marqués ML,Rodríguez-Puyol D,Rodríguez-Puyol M

更新日期：1999-01-01 00:00:00

abstract：:Heparin-binding EGF-like growth factor (HB-EGF), a member of the epidermal growth factor (EGF) family, can protect intestinal epithelial cells from various forms of injury in vitro and attenuate intestinal ischemia/reperfusion damage in vivo. With the goal of eventual clinical use of HB-EGF to protect the intestines f...

journal_title：Peptides

authors： Feng J,Mehta VB,El-Assal ON,Wu D,Besner GE

更新日期：2006-06-01 00:00:00

abstract：:Two peptides, with a molecular mass of about 11 kDa and an N-terminal sequence abundant in arginine and glutamine residues, were isolated from wax gourd seeds. The isolation protocol included affinity chromatography on Affi-gel blue gel, ion-exchange chromatography on Mono-S and gel filtration on Superdex 75. The pept...

journal_title：Peptides

authors： Ng TB,Parkash A,Tso WW

更新日期：2003-01-01 00:00:00

abstract：:Histidyl-proline diketopiperazine (cyclo(His-Pro), a metabolite of the neuropeptide thyrotropin releasing hormone, has been shown to possess intrinsic biological activities. The binding of this peptide to various tissue particulate preparations was investigated. While the peptide showed no apparent binding to particul...

journal_title：Peptides

authors： Bataini F,Koch Y,Takahara Y,Peterkofsky A

更新日期：1983-01-01 00:00:00

abstract：:Immunoreactive alpha-MSH was found in human skin and the skin of numerous other mammals. After hypophysectomy the concentration of alpha-MSH in rat skin showed little change suggesting that the pituitary is not the source of this MSH. In human skin the highest concentration was found in the epidermis and HPLC revealed...

journal_title：Peptides

authors： Thody AJ,Ridley K,Penny RJ,Chalmers R,Fisher C,Shuster S

更新日期：1983-11-01 00:00:00

abstract：:Dendroaspis natriuretic peptide (DNP) is one of four members of the natriuretic peptide family sharing functional and structural properties. The purpose of the present study was to elucidate the physiological role of DNP on renal functions and its cellular mechanism in the rabbit kidney. DNP (5 μg/kg/min) infused intr...

journal_title：Peptides

authors： Kim SM,Kim SY,Kim SH,Cho KW,Kim SZ

更新日期：2012-01-01 00:00:00

abstract：:The effect of caseinomacropeptide (CMP) (the [106-169] fragment of kappa-casein produced during digestion of milk protein), was studied in anesthetized rats using bile diversion for a pure pancreatic juice collection system. Intraduodenal administration of CMP induced a dose-related specific stimulation of pancreatic ...

journal_title：Peptides

authors： Pedersen NL,Nagain-Domaine C,Mahé S,Chariot J,Rozé C,Tomé D

更新日期：2000-10-01 00:00:00

abstract：:Venom small peptides that target neurotrophin receptors might be beneficial in neurodegeneration, including Parkinsońs disease (PD). Their small size, ease of synthesis, structural stability and target selectivity make them important tools to overcome the limitations of endogenous neurotrophins as therapeutic agents. ...

journal_title：Peptides

authors： Bernardes CP,Santos NAG,Sisti FM,Ferreira RS,Santos-Filho NA,Cintra ACO,Cilli EM,Sampaio SV,Santos AC

更新日期：2018-06-01 00:00:00

abstract：:beta-Lactotensin (beta-LT) is a bioactive peptide derived from bovine milk beta-lactoglobulin and is a natural ligand for neurotensin receptors. We examined the effect of beta-LT on restraint stress and fear memory in mice. Mice subjected to acute restraint stress exhibited a decreased number of head-dips and increase...

journal_title：Peptides

authors： Yamauchi R,Wada E,Yamada D,Yoshikawa M,Wada K

更新日期：2006-12-01 00:00:00

abstract：:Antimicrobial peptides allegedly exert their action on microbial membranes. Bovine lactoferrin enfold two antimicrobial domains, lactoferricin B (LFcin B) and lactoferrampin (LFampin). Effects of representative peptides thereof on the membranes of Candida albicans and Escherichia coli were investigated. Confocal laser...

journal_title：Peptides

authors： van der Kraan MI,van Marle J,Nazmi K,Groenink J,van 't Hof W,Veerman EC,Bolscher JG,Nieuw Amerongen AV

更新日期：2005-09-01 00:00:00

abstract：:The gut-derived hormone peptide YY (PYY) is most commonly known for its effect on satiety, decreasing food intake and body weight in animals and humans. However, PYY is also involved in a wide range of digestive functions including regulating insulin secretion and glucose homeostasis. Over the last few years, there ha...

journal_title：Peptides

authors： Boey D,Sainsbury A,Herzog H

更新日期：2007-02-01 00:00:00

abstract：:Although several low amphipathic peptides have been known to exhibit antimicrobial activity, their mode of action has not been completely elucidated. In this study, using designed low amphipathic peptides that retain different alpha-helical content and hydrophobicity, we attempted to investigate the mechanism of these...

journal_title：Peptides

authors： Yamamoto N,Tamura A

更新日期：2010-05-01 00:00:00

abstract：:The striatum is richly innervated by both enkephalinergic and dopaminergic neurons, providing an anatomic framework from which intimate functional interrelationships between these neuronal systems may be postulated. Accordingly, many functional processes within dopamine neurons have been shown to be modulated by opioi...

journal_title：Peptides

authors： George SR,Kertesz M

更新日期：1987-05-01 00:00:00

abstract：:Capsaicin-sensitive sensory nerves participate in the regulation of cardiovascular functions both in the normal state and the pathophysiology of hypertension through the actions of potent vasodilator neuropeptides, including calcitonin gene-related peptide (CGRP). CGRP, a very potent vasodilator, is the predominant ne...

journal_title：Peptides

authors： Deng PY,Li YJ

更新日期：2005-09-01 00:00:00

abstract：:Increased plasma levels of neuropeptide Y (NPY)-like immunoreactivity (p-NPY-LI) have been described in hemodialysis (HD) patients. In this investigation the effect of a standard HD on p-NPY-LI, analyzed by radioimmunoassay and reverse-phase high performance liquid chromatography (HPLC), was studied. During dialysis p...

journal_title：Peptides

authors： Hegbrant J,Thysell H,Ekman R

更新日期：1995-01-01 00:00:00

abstract：:The effects of arginine vasotocin (AVT), 4-6 ng/kg, on renal function and plasma prolactin (PRL) were determined in conscious American foxhounds undergoing a water diuresis. Intravenous AVT produced an antidiuresis, kaliuresis and inconsistent natriuresis, independently of changes in GFR, blood pressure, heart rate an...

journal_title：Peptides

authors： Gilmore JP,Wesley CR,Huffman L,Nemeh MN

更新日期：1982-11-01 00:00:00

abstract：:We previously demonstrated that intracerebroventricular (i.c.v.) administration of the substance P (SP) aminoterminal fragment SP(1-7) attenuates the expression of morphine withdrawal in the male rat. In this study we have used a synthetic analogue of this peptide, i.e. the SP(1-7) amide showing higher binding potency...

journal_title：Peptides

authors： Zhou Q,Carlsson A,Botros M,Fransson R,Sandström A,Gordh T,Hallberg M,Nyberg F

更新日期：2009-12-01 00:00:00

abstract：:The effect of melanin-concentrating hormone (MCH) on the release of alpha-melanocyte stimulating hormone (alpha-MSH) from the tilapia pituitary gland was studied in vitro. In a superfusion set up, 10 nM to 1 microM synthetic salmon MCH caused a concentration-dependent inhibition of alpha-MSH release from tilapia neuro...

journal_title：Peptides

authors： Gröneveld D,Balm PH,Wendelaar Bonga SE

更新日期：1995-01-01 00:00:00

abstract：:CART (cocaine- and amphetamine-regulated transcript) peptides are neuropeptides abundant in the central nervous system and periphery found to be involved in the regulation of food intake behavior and other physiological processes. Recently, we reported specific binding of (125)I-CART(61-102) to the rat adrenal pheochr...

journal_title：Peptides

authors： Maixnerová J,Hlavácek J,Blokesová D,Kowalczyk W,Elbert T,Sanda M,Blechová M,Zelezná B,Slaninová J,Maletínská L

更新日期：2007-10-01 00:00:00

abstract：:The opioid peptides, [3H]DAGO and [3H]DPDPE, bound to rat and guinea pig brain homogenates with a high, nanomolar affinity and to a high density of mu and delta receptors, respectively. [3H]DAGO binding to mu receptors was competitively inhibited by unlabelled opioids with the following rank order of potency: DAGO gre...

journal_title：Peptides

authors： Sharif NA,Hughes J

更新日期：1989-05-01 00:00:00

abstract：:Vasoactive intestinal peptide (VIP) enhances angiogenesis in rats with focal cerebral ischemia. In the present study, we investigated the molecular mechanism of the proangiogenic action of VIP using an in vitro ischemic model, in which rat brain microvascular endothelial cells (RBMECs) are subjected to oxygen and gluc...

journal_title：Peptides

authors： Yang J,Shi QD,Song TB,Feng GF,Zang WJ,Zong CH,Chang L

更新日期：2013-04-01 00:00:00

abstract：:Pharmacological experiments suggest that satiation associated with intestinal infusion of several nutrients is mediated by CCK-A receptors. Otsuka Long-Evans Tokushima Fatty, (OLETF), rats do not express CCK-A receptors and are insensitive to the satiation-producing effects of exogenous CCK. To further evaluate the ro...

journal_title：Peptides

authors： Covasa M,Ritter RC

更新日期：2001-08-01 00:00:00

abstract：:Native peptides can be regarded as surrogate markers for protease activity in biological samples. Analysis of peptides by peptidomics allows to monitor protease activity in vivo and to describe the influence of protease inhibition. To elucidate the potential of peptides as markers for in vivo protease inhibition we an...

journal_title：Peptides

authors： Tammen H,Hess R,Rose H,Wienen W,Jost M

更新日期：2008-12-01 00:00:00

abstract：:Using Surface Plasmon Resonance (SPR) we investigated the interaction of seven neuropeptides with different characteristics and beta-amyloid (Abeta42) peptide, with membranes containing gangliosides. A wide range of affinities characterized the bindings (K(D) = 10(-3)- 10(-7) M), following the scheme: for GM1, Abeta42...

journal_title：Peptides

authors： Valdes-Gonzalez T,Inagawa J,Ido T

更新日期：2001-07-01 00:00:00

abstract：:Pharmacological study of Phe-Met-Leu-Phe-amide (FMRFa) receptors is hindered by the lack of selective ligands. The classification of these selective ligands is further hampered by the limited availability of functional assays. In this study, we evaluated several synthetic FMRFa analogs for agonist and antagonist activ...

journal_title：Peptides

authors： Heyliger SO,Payza K,Rothman RB

更新日期：1998-01-01 00:00:00

abstract：:Neuropeptide Y-containing nerve fibers have previously been demonstrated to innervate the mammalian ovary. These nerve fibers innervate primarily the vasculature. In this study we have developed a method for in vivo measurement of the ovary blood flow rate by means of the 133Xe method. Using this technique we measured...

journal_title：Peptides

authors： Jørgensen JC,Sejrsen P

更新日期：1990-05-01 00:00:00

abstract：:In this study we investigated the role that dopaminergic pathways play in the miotic effect exerted by neurotensin after intracameral administration. Neurotensin was injected into the anterior chamber (AC) at a dose of 30 micrograms to 4 groups of albino rabbits which had previously undergone the following treatment: ...

journal_title：Peptides

authors： Tassorelli C,Spampinato D,Caruso P,Cavaliere S,Micieli G,Drago F,Nappi G

更新日期：1990-11-01 00:00:00

abstract：:Effects of spantide ([D-Arg1,D-Trp7,9,Leu11]substance P) on coronary resistance vessels were studied in isolated guinea pig hearts perfused at constant rate with isotonic buffer containing 20 or 40 mM KCl. Spantide (1 microM) caused a 20-fold rightward shift of the substance P (SP) dose-response curve for vasodilation...

journal_title：Peptides

authors： Hoover DB

更新日期：1991-09-01 00:00:00

abstract：:The 41-residue corticotropin releasing factor (CRF) was synthesized by the solid phase method. The synthetic CRF and arginine vasopressin (AVP) were examined for ACTH releasing activity and effects on the release of 5 other pituitary hormones in vivo and in vitro. Injection of the CRF into pharmacologically blocked ra...

journal_title：Peptides

authors： Turkelson CM,Arimura A,Culler MD,Fishback JB,Groot K,Kanda M,Luciano M,Thomas CR,Chang D,Chang JK,Shimizu M

更新日期：1981-01-01 00:00:00

abstract：:Prolactin releasing peptide (PrRP) was originally reported to act in the anterior lobe of the pituitary gland to stimulate prolactin (PRL) release; however, numerous other pharmacologic actions of PrRP have been described. In the central nervous system PrRP inhibits food intake, stimulates sympathetic tone, and activa...

journal_title：Peptides

authors： Samson WK,Taylor MM

更新日期：2006-05-01 00:00:00