Focal metabolic effects of angiotensin and captopril on subregions of the rat subfornical organ.

abstract：:The cDNAs encoding the preprohormones of the regulatory peptides cholecystokinin (CCK) and the related gastrin have been identified in a number of vertebrate species. However, from birds only chicken preprogastrin is known. In the present study preproCCK cDNA was identified in two species of birds, ostrich and chicken...

journal_title：Peptides

authors： Jønson L,Schoeman N,Saayman H,Naudé R,Jensen H,Johnsen AH

更新日期：2000-09-01 00:00:00

abstract：:Kallikrein-related peptidases (KLKs) are a group of serine proteases, expressed in several tissues. Their activity is regulated by inhibitors including members of the serine protease of Kazal-type (SPINK) family. Recently, we discovered that SPINK6 is expressed in human skin and inhibits KLK5, KLK7, KLK14 but not KLK8...

journal_title：Peptides

authors： Kantyka T,Fischer J,Wu Z,Declercq W,Reiss K,Schröder JM,Meyer-Hoffert U

更新日期：2011-06-01 00:00:00

abstract：:The insect kinin neuropeptides have been implicated in the regulation of water balance, digestive organ contraction, and energy mobilization in a number of insect species. A previous solution conformation study of an active, restricted-conformation cyclic analog, identified two possible turn conformations as the likel...

journal_title：Peptides

authors： Nachman RJ,Zabrocki J,Olczak J,Williams HJ,Moyna G,Ian Scott A,Coast GM

更新日期：2002-04-01 00:00:00

abstract：:A novel antimicrobial peptide, with molecular mass of 1602.0469Da, produced by Brevibacillus laterosporus strain A60 was isolated and purified from the soil of mango plants. The purification procedure consisted of ammonium sulfate precipitation, cation exchange chromatography on an HiTrap SP HP column, thin layer chro...

journal_title：Peptides

authors： Zhao J,Guo L,Zeng H,Yang X,Yuan J,Shi H,Xiong Y,Chen M,Han L,Qiu D

更新日期：2012-02-01 00:00:00

abstract：:Glucagon-like peptide-1 (GLP-1) is a proglucagon-derived hormone with cellular protective actions. We hypothesized that GLP-1 would protect the endothelium from injury during inflammation. Our aims were to determine the: (1) effect of GLP-1 on basal microvascular permeability, (2) effect of GLP-1 on increased microvas...

journal_title：Peptides

authors： Dozier KC,Cureton EL,Kwan RO,Curran B,Sadjadi J,Victorino GP

更新日期：2009-09-01 00:00:00

abstract：:Low-density lipoprotein (LDL) concentrations have been linked to altered responses to endogenous vasodilators and vasoconstrictors. We evaluated retrospectively the relationship between LDL and vasoconstrictor (endothelin-1, phenylephrine) responsiveness of the forearm vasculature in 15 elderly healthy volunteers with...

journal_title：Peptides

authors： Romerio SC,Linder L,Flammer J,Haefeli WE

更新日期：2000-06-01 00:00:00

abstract：:ACTH/MSH(4-10) (10 micrograms/kg/b.i.d.; IP), administered to pregnant Sprague-Dawley rats during gestational days (GD) 3 to 12, significantly increased the metabolic activity of extensor digitorum longus (EDL) muscle at postnatal day 14. ACTH/MSH peptide, administered from day of birth to postnatal day 13, had no eff...

journal_title：Peptides

authors： Rose KJ,Strand FL

更新日期：1990-01-01 00:00:00

abstract：:Leptin has recently been discussed as a novel biomarker for the clinical outcome of critical illness. This study aims to investigate the prognostic value of leptin with regard to long-term clinical outcomes in patients with intracerebral hemorrhage. In 50 healthy controls and 92 patients with acute spontaneous basal g...

journal_title：Peptides

authors： Zhang X,Lu XM,Huang LF,Li X

更新日期：2013-05-01 00:00:00

abstract：:Apelin and its receptor APJ are expressed in fetal tissues but their function and regulation remain largely unknown. In rat, maternal treatment with a nitric oxide synthase inhibitor inducing hypertension was used to investigate apelin plasma levels in mother/fetus pairs and on the gene expression level of the apelin/...

journal_title：Peptides

authors： Ivars J,Butruille L,Knauf C,Bouckenooghe T,Mayeur S,Vieau D,Valet P,Deruelle P,Lesage J

更新日期：2012-05-01 00:00:00

abstract：:The hypophysiotrophic hormone corticotropin releasing factor (CRF) stimulates the anterior pituitary corticotroph to export stress hormones such as adrenocorticotrophic hormone (ACTH). In rat anterior pituitary cells, CRF-induced elevation of cyclic AMP was profoundly potentiated (by an order of magnitude) by stimulat...

journal_title：Peptides

authors： Cronin MJ,Zysk JR,Baertschi AJ

更新日期：1986-09-01 00:00:00

abstract：:Copeptin can reflect individual's stress state and are correlated with poor outcome of critical illness. The occurrence of postoperative delirium (POD) and cognitive dysfunction (POCD) is associated with worse outcome after coronary artery bypass graft (CABG) surgery. The present study aimed to investigate the ability...

journal_title：Peptides

authors： Dong S,Li CL,Liang WD,Chen MH,Bi YT,Li XW

更新日期：2014-09-01 00:00:00

abstract：:Pituitary adenylate cyclase-activating peptide (PACAP) is a neuropeptide with strong bronchodilator capacity, present in the human airways. There is recent evidence that PACAP decreases the release of proinflammatory cytokines. We have previously shown that PACAP inhibits neutrophil chemotaxis, but altogether little i...

journal_title：Peptides

authors： Kinhult J,Egesten A,Uddman R,Cardell LO

更新日期：2002-10-01 00:00:00

abstract：:A novel 6.6 kDa antifungal peptide (NFAP) from the culture supernatant of the mold, Neosartorya fischeri (anamorf: Aspergillus fischerianus), and its encoding gene were isolated in this study. NFAP is a small, basic and cysteine-rich protein consisting of 57 amino acid residues. It shows 37.9-50% homology to similar p...

journal_title：Peptides

authors： Kovács L,Virágh M,Takó M,Papp T,Vágvölgyi C,Galgóczy L

更新日期：2011-08-01 00:00:00

abstract：:Angiotensin(1-7) had a compound effect on blood pressure of pithed Sprague-Dawley rats. The initial phase of the response consisted of an increase in MAP of short duration and independent of injected dose, followed by a decline of arterial pressure to values below baseline. Both the magnitude (range: -4 +/- 1 to -13 +...

journal_title：Peptides

authors： Benter IF,Diz DI,Ferrario CM

更新日期：1993-07-01 00:00:00

abstract：:To determine if different subtypes of mu-opioid receptors were involved in antinociception induced by endomorphin-1 and endomorphin-2, the effect of pretreatment with various mu-opioid receptor antagonists beta-funaltrexamine, naloxonazine and 3-methylnaltrexone on the inhibition of the paw-withdrawal induced by endom...

journal_title：Peptides

authors： Sakurada S,Hayashi T,Yuhki M,Fujimura T,Murayama K,Yonezawa A,Sakurada C,Takeshita M,Sato T,Zadina JE,Kastin AJ,Sakurada T

更新日期：2002-05-01 00:00:00

abstract：:Female Zucker lean and obese rats were treated for 14 days with 3.5 micromol/kg oleoyl-estrone (OE) in liposomes (Merlin-2). After 0, 3, 6, 10, and 14 days of treatment, the rats were killed and hypothalamic nuclei (lateral preoptic, median preoptic, paraventricular, ventromedial and arcuate) were used for neuropeptid...

journal_title：Peptides

authors： Cabot C,Grasa MM,Adán C,Pérez-Clausell J,Virgili J,Estruch J,Fernández-Löpez JA,Remesar X,Alemany M

更新日期：1998-01-01 00:00:00

abstract：:Synthetic peptides containing a phosphorylation site for protein kinase CK2 were used to investigate their binding properties to other peptides/proteins. The aim of this work was to find an efficient procedure to search for these peptide/protein ligands. The goal was successfully achieved through screening of random p...

journal_title：Peptides

authors： Cardellini E,Felici F,Gianfranceschi GL

更新日期：2004-02-01 00:00:00

abstract：:The prothoracicotropic hormones (PTTH) are cerebral peptides that control insect postembryonic development by stimulating the prothoracic glands to synthesize ecdysteroids. Using immunoaffinity chromatography and SDS-PAGE, a 25.5 kDa big PTTH has been purified from Manduca sexta. Based upon SDS-PAGE and Western blot a...

journal_title：Peptides

authors： Muehleisen DP,Gray RS,Katahira EJ,Thomas MK,Bollenbacher WE

更新日期：1993-05-01 00:00:00

abstract：:Cholecystokinin octapeptides (CCK8s) have been purified from methanol extracts of two brains from each of two Australian marsupials, Tammar Wallaby and Eastern Quoll, containing 3 nmol and 2 nmol of the peptides, respectively. Immunoreactive CCK was concentrated on QMA SepPak cartridges and purified by two successive ...

journal_title：Peptides

authors： Fan ZW,Eng J,Shaw G,Yalow RS

更新日期：1988-03-01 00:00:00

abstract：:The major amyloid-beta (Abeta) peptides found in the brain of familial and late onset Alzheimer's disease include the full-length Abeta1-42 and N-terminally truncated, pyroglutamylated peptides Abetap3-42 and Abetap11-42. The biophysical properties of Abeta1-42 have been extensively studied, yet little is known about ...

journal_title：Peptides

authors： Sanders HM,Lust R,Teller JK

更新日期：2009-05-01 00:00:00

abstract：:Urotensin II (UII) induces the development of cardiac remodeling and atherosclerosis by promoting hypertrophy of cardiomyocytes and mitogenesis of fibroblasts and vascular smooth muscle cells. But its effect on cardiac side population cells (CSPs), one of somatic stem cells, is unclear. The present study examined the ...

journal_title：Peptides

authors： Gong H,Ma H,Liu M,Zhou B,Zhang G,Chen Z,Jiang G,Yan Y,Yang C,Kanda M,Wu J,Yuan J,Li L,Nagai T,Komuro I,Ge J,Zou Y

更新日期：2011-05-01 00:00:00

abstract：:The binding and internalization of a cytotoxic analogue of luteinizing hormone-releasing hormone (LH-RH), T-98 (agonist [D-Lys6]LH-RH linked to glutaryl-2-(hydroxymethyl)anthraquinone), by rat anterior pituitary cells was investigated. Analogue T-98 was bound to pituitary membrane binding sites for LH-RH with a high a...

journal_title：Peptides

authors： Szöke B,Horváth J,Halmos G,Rékási Z,Groot K,Nagy A,Schally AV

更新日期：1994-01-01 00:00:00

abstract：:The purpose of this work was to determine the mechanism of the antisecretory effect of peptide YY in the rat colon and whether this effect is physiological. In this prospect, doses of exogenous peptide YY producing physiological and supraphysiological plasma levels were intravenously infused in rats provided with colo...

journal_title：Peptides

authors： Chariot J,Tsocas A,Souli A,Presset O,Rozé C

更新日期：2000-01-01 00:00:00

abstract：:alpha-MSH immunoreactive peptides were fractionated and characterized in rat and human brain and rat pituitary by reversed phase high pressure liquid chromatographic techniques. alpha-MSH and deacetylated alpha-MSH were two major naturally existing peptides in both brain and pituitary gland. Subsequent experiments exa...

journal_title：Peptides

authors： O'Donohue TL,Handelmann GE,Chaconas T,Miller RL,Jacobowitz DM

更新日期：1981-10-01 00:00:00

abstract：:The effects of atrial natriuretic factor (ANF) on [3H]norepinephrine ([3H]NE) release evoked by a sodium-free medium (SFM) were studied. Experiments were performed in rat adrenal medulla slices incubated in vitro. Results showed that [3H]NE release evoked by the omission of Na+ was decreased by 10 nM ANF. In addition,...

journal_title：Peptides

authors： Vatta MS,Papouchado ML,Bianciotti LG,Fernandez BE

更新日期：1994-01-01 00:00:00

abstract：:Treatment of cultured rat hepatocytes with cyclosporin A (0.01-1 microM) for 24, 48, or 72 h in the presence of insulin and epidermal growth factor induced an inhibition on cell proliferation in a time- and concentration-dependent manner, with an IC50 = 0.05 microM CsA corresponding to 48-h treatment. The inhibitory e...

journal_title：Peptides

authors： Rodriguez-Henche N,Román ID,Fueyo J,Menor C,Zueco JA,Prieto JC,Guijarro LG

更新日期：1998-01-01 00:00:00

abstract：:Ablation of the frontal neocortex markedly enhanced the antinociceptive and cataleptic actions of beta-endorphin injected into the lateral ventricle of rat brain. This enhanced response was not affected by simultaneous administration of cholecystokinin octapeptide (CCK-8). In sham-operated rats, however, CCK-8 suppres...

journal_title：Peptides

authors： Itoh S,Katsuura G

更新日期：1985-03-01 00:00:00

abstract：:Amphibians exhibit various, characteristic adaptations related to their "incomplete" shift from the aquatic to the terrestrial habitat. In particular, the integument was subject to a number of specialized modifications during the evolution of these animals. In this review, we place special emphasis on endogenous host-...

journal_title：Peptides

authors： König E,Bininda-Emonds OR,Shaw C

更新日期：2015-01-01 00:00:00

abstract：:To study the effects of inducing stereo-chemical modifications in the structure of dermorphin (DM) so as to improve its mu-opioid receptor affinity and its resistance to C-terminal enzymatic degradation, in the Institute of Molecular Genetics of Moscow, we synthesized a new DM analogue ([DPro(6)]DM) and analyzed the c...

journal_title：Peptides

authors： Broccardo M,Usenko AB,Uranova MG,Guzevatykh LS,Kamensky AA,Andreeva LA,Alfeeva LY,Myasoedov NF,Giannini E,Improta G,Emel'yanova TG

更新日期：2003-03-01 00:00:00

abstract：:Radioautographic determinations of 125I-[Tyr0,D-Trp8]somatostatin-14 (125I-SRIF) binding sites were performed on frozen serial sections of the locus coeruleus (LC) of control rats and of rats subjected to either bilateral microinjections of 6 hydroxydopamine (6-OHDA) into the LC or unilateral microinjection into the a...

journal_title：Peptides

authors： Epelbaum J,Bluet-Pajot MT,Llorens-Cortes C,Kordon C,Mounier F,Senut MC,Videau C

更新日期：1990-01-01 00:00:00