Abstract:
:The thyroid gland is known to harbor cholinergic and VIPergic nerves. In the present study, the influences of cholinergic stimulation by carbachol, cholinergic blockade by methylatropine and stimulation with various VIP sequences on basal, TSH-induced and VIP-induced thyroid hormone section were investigated in vivo in mice. The mice were pretreated with 125I and thyroxine; the subsequent release of 125I is an estimation of thyroid hormone secretion. It was found that basal radioiodine secretion was inhibited by both carbachol and methylatropine. Furthermore, TSH-induced radioiodine secretion was inhibited already by a low dose of carbachol. Moreover, a high dose of carbachol could inhibit VIP-induced radioiodine secretion. Methylatropine did not influence TSH- or VIP-stimulated radioiodine secretion, but counteracted the inhibitory action of carbachol on TSH- and VIP-induced radioiodine release. In addition, contrary to VIP, six various synthesized VIP fragments had no effect on basal or stimulated radioiodine release. It is concluded that basal thyroid hormone secretion is inhibited by both cholinergic activation and blockade. Furthermore, TSH-induced thyroid hormone secretion is more sensitive to inhibition with cholinergic stimulation than is VIP-induced thyroid hormone secretion. In addition, the VIP stimulation of thyroid hormone secretion seems to require the full VIP sequence.
journal_name
Peptidesjournal_title
Peptidesauthors
Ahrén Bdoi
10.1016/0196-9781(85)90157-3subject
Has Abstractpub_date
1985-07-01 00:00:00pages
585-9issue
4eissn
0196-9781issn
1873-5169pii
0196-9781(85)90157-3journal_volume
6pub_type
杂志文章相关文献
PEPTIDES文献大全abstract::The family of natriuretic peptides (NPs) discovered in mammalian tissues including cardiac atrium and brain consists of three members, namely, atrial, B- and C-type natriuretic peptides (ANP, BNP, CNP). Since the discovery, basic and clinical studies have been vigorously performed to explore the biological functions a...
journal_title:Peptides
pub_type: 杂志文章,评审
doi:10.1016/j.peptides.2020.170352
更新日期:2020-10-01 00:00:00
abstract::Angiotensin infusion increased glucose metabolism in 4 of 7 subdivisions of the rat subfornical organ, the effect being stronger in ventromedial compared to dorsolateral zones across the rostrocaudal axis. [Sar1-Leu8]Angiotensin II attenuated metabolic responses to intravenous angiotensin in all subfornical organ subr...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(90)90059-e
更新日期:1990-05-01 00:00:00
abstract::In recent years our knowledge of the nervous control of the cerebral circulation has increased. The use of denervations and retrograde tracing in combination with immunohistochemical techniques has demonstrated that cerebral vessels are supplied with sympathetic, parasympathetic, and sensory nerve fibers and possibly ...
journal_title:Peptides
pub_type: 杂志文章,评审
doi:10.1016/s0196-9781(01)00408-9
更新日期:2001-06-01 00:00:00
abstract::The binding activity of several galanin fragments and analogs was measured on specific receptors present in rat brain and the rat pancreatic beta cell line Rin m 5F. In both tissues it was observed that: 1) galanin(3-29), galanin(10-29) and [Ile2]-galanin were ineffective for inhibiting [125I] galanin binding and 2) a...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(89)90109-5
更新日期:1989-07-01 00:00:00
abstract::C-type natriuretic peptide (CNP) is assuming increasing importance in cardiovascular disease, and in adults its plasma levels are related to clinical and functional disease severity. Data are scarce regarding the reference values for CNP in infancy. Aim of this study was to assess the reference intervals for CNP in hu...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2011.11.005
更新日期:2012-01-01 00:00:00
abstract::Two peptides, rHRnG and hproHRnG, which were encoded by the nucleotide sequences complementary to mRNA of rat hypothalamic gonadotropin-releasing hormone (GnRH) and human placental proGnRH(-3-13), respectively, were synthesized. A remarkable hydropathic anti-complementarity was observed in the N-terminal region betwee...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(86)90144-0
更新日期:1986-11-01 00:00:00
abstract::Recent refinements in methodology now permit the study of endogenous peptide hormones in their individual target cells. The investigations reported here deal with the question of whether endogenous ACTH can be detected in its target cells in the highly active adrenal gland of the normally lactating rat. This question ...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(80)90062-5
更新日期:1980-10-01 00:00:00
abstract::Methods have been developed for the microsurgical interruption of nerve pathways in the wall of the intestine and for the immunohistochemical localization of antigens in whole mounts. These methods have made it possible to determine accurately the distributions and projections of neurons containing different putative ...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(81)90022-x
更新日期:1981-01-01 00:00:00
abstract::The typical cardiovascular response to polymicrobial sepsis is characterized by an early, hyperdynamic phase followed by a late, hypodynamic phase. Although the factors and/or mediators responsible for producing the transition from the hyperdynamic to the hypodynamic stage are not fully understood, recent studies have...
journal_title:Peptides
pub_type: 杂志文章,评审
doi:10.1016/s0196-9781(01)00534-4
更新日期:2001-11-01 00:00:00
abstract::Generally, biomacromolecules, such as DNA, RNA, and proteins, cannot freely permeate into cells from outside the membrane. Protein transduction domains (PTDs) are peptides containing a large number of basic amino acids that can deliver macromolecules into living cells. Arginine-rich intracellular delivery (AID) peptid...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2009.06.006
更新日期:2009-09-01 00:00:00
abstract::Dispersed cells from chicken brain and liver were found to possess cell surface binding sites for 125I-neurotensin (125I-NT). Scatchard analyses indicated the presence of high affinity (K4, 25-80 pM) and low affinity (Kd, 250-450 pM) components in adult tissues. Binding capacity was reduced 25-40% by incubation with p...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(97)00052-1
更新日期:1997-01-01 00:00:00
abstract::In an attempt to establish the role of F8Famide in opioid activity modulation, we examined the effects of intracerebroventricular administration of the F8Famide analogs (1DME)Y8Fa and (3D)Y8Fa on intestinal transit in mice. (1DME)Y8Fa (0.88 to 22 nmol) inhibited intestinal transit as did F8Famide and morphine. An IP i...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(93)90108-s
更新日期:1993-07-01 00:00:00
abstract::Angiotensin-(1-7) [Ang-(1-7)] develops its functions interacting with Mas receptor. Mas receptor was recently identified in the DRG and its activation by Ang-(1-7) resulted in peripheral antinociception against PGE2 hyperalgesia in an opioid-independent pathway. Nevertheless, the mechanism by which Ang-(1-7) induce pe...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2015.04.011
更新日期:2015-07-01 00:00:00
abstract::[125I]beta-endorphin bound to high affinity (Kd = 0.25 nM) receptors in the caudal dorsomedial medulla of rats with a Bmax of 97 fmol/mg protein. The relative potency for displacement of [125I]beta-endorphin binding was: beta-endorphin(1-31) > beta-endorphin(1-27) > DAMGO > naloxone > N-acetyl-beta-endorphin(1-31) > U...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(98)00024-2
更新日期:1998-01-01 00:00:00
abstract::In this study, antimicrobial peptide S-thanatin (Ts) was chemically synthesized and linked to keyhole limpet hemocyanin (KLH) and bovine serum albumin (BSA) by carbodiimide reagent. Rabbits were immunized with Ts-KLH and polyclonal antibody against Ts was purified by fractional precipitation of ammonium sulfate, coupl...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2011.05.009
更新日期:2011-07-01 00:00:00
abstract::Intravenous (IV) infusions of neurotensin (NT) in anesthetized guinea pigs elicited dose-dependent pressor effects and tachycardia. Both effects were significantly reduced or abolished in guinea pigs given a chronic treatment with the neurotoxin capsaicin. In guinea pig isolated atria NT evoked a positive inotropic an...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(87)90140-9
更新日期:1987-11-01 00:00:00
abstract::In order to study a possible direct action of LH-RH analogs on the pituitary lactotrophs, we investigated the effect of long-term in vivo pretreatment with D-Trp-6-LH-RH on in vitro secretion of PRL and luteinizing hormone (LH) by the pituitary glands from male and female rats. In vivo pretreatment with D-Trp-6-LH-RH ...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(85)90333-x
更新日期:1985-09-01 00:00:00
abstract::Somatostatin-14 (S14) and its precursor, somatostatin-28 (S28), are widely distributed throughout the rat brain, suggesting that they could act as neurotransmitter or neuromodulator in the central nervous system. The present study was undertaken to study the localization of S14 and S28 receptors in the rat brain deter...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(84)90078-0
更新日期:1984-05-01 00:00:00
abstract::Guanylyl cyclases (GC) are widely distributed enzymes that signal via the production of the second messenger cGMP. The particulate guanylyl cyclases share a similar topology: an extracellular ligand binding domain and intracellular regulatory kinase-homology and cyclase catalytic domains. The natriuretic peptide recep...
journal_title:Peptides
pub_type: 杂志文章,评审
doi:10.1016/j.peptides.2004.08.027
更新日期:2005-06-01 00:00:00
abstract::The vasoactive peptide urotensin-II (U-II) is best known for its ability to regulate peripheral vascular and cardiac contractile function in vivo, and recent in vitro studies have suggested a role for the peptide in the control of vascular remodeling by inducing smooth muscle proliferation and fibroblast-mediated coll...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2005.05.028
更新日期:2005-12-01 00:00:00
abstract::Receptor binding analysis was performed in the renal medulla from 2-month-old rats, an extrapituitary tissue containing the highest level of GHRH receptor mRNA. At 4 degrees C, in the presence of a cocktail of protease inhibitors, binding of [125I-Tyr(10)]hGHRH (1-44)NH(2) to medullary homogenates was specific, time-d...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(02)00029-3
更新日期:2002-06-01 00:00:00
abstract::The involvement of the hypothalamic beta-endorphinergic system in behavioral processes has previously been studied in adult rats. In the present report, we studied the effects of undernutrition and of inhibitory avoidance training on the hypothalamic beta-endorphin-like immunoreactivity of 21-day-old and adult rats. R...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(88)90117-9
更新日期:1988-07-01 00:00:00
abstract::Opioid receptor analyses of deltorphin A (H-Tyr-D-Met-Phe-His-Leu-Met-Asp-NH2) analogues indicated the following: (a) increased negativity differentially affected affinities (Ki) and selectivity (Ki mu/Ki delta); (b) shifted sequence heptapeptides, [Asp5,Leu6,Met-NH2(7)] and [Asp4,His5,Leu6,Met-NH2(7)], reversed selec...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(93)90006-3
更新日期:1993-01-01 00:00:00
abstract::Neurotensin (NT) produces behavioral and physiological effects, including analgesia and hypotheria, when administered into the CNS. Fischer and Lewis rats exhibit differential behavioral responses to central NT receptor activation. To further characterize these differences, we assessed central NT-induced analgesia and...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2003.06.004
更新日期:2003-08-01 00:00:00
abstract::To identify male-specific genes that could be involved in male development, we screened a subtracted male reproductive tract library and isolated a novel gene named Mar-Mrr (M. rosenbergii male reproduction-related gene). The Mar-Mrr cDNA sequence consists of 683 nucleotides with a 333 nucleotide open reading frame, e...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2005.09.004
更新日期:2006-04-01 00:00:00
abstract::Radioautographic determinations of 125I-[Tyr0,D-Trp8]somatostatin-14 (125I-SRIF) binding sites were performed on frozen serial sections of the locus coeruleus (LC) of control rats and of rats subjected to either bilateral microinjections of 6 hydroxydopamine (6-OHDA) into the LC or unilateral microinjection into the a...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(90)90104-d
更新日期:1990-01-01 00:00:00
abstract::The effect of naturally occurring cannabinoids, delta 9-tetrahydrocannabinol (THC), cannabinol (CBN) and cannabidiol (CBD), on the brain receptors for thyrotropin releasing hormone (TRH) was investigated. TRH receptors were labeled with 3H-(3-MeHis2)TRH (3H-MeTRH). 3H-MeTRH bound specifically to rat brain membranes at...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(88)90120-9
更新日期:1988-07-01 00:00:00
abstract::Tachykinins are thought to be involved in extrinsic control of motility in the gastrointestinal tract. Using the isolated perfused porcine antrum with intact vagal innervation, we studied the effects of substance P, neurokinin A and capsaicin infusion, and electrical stimulation of the vagus nerves on antral motility ...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(97)00226-x
更新日期:1997-01-01 00:00:00
abstract::Using autoradiographic method and 125I-Tyro rat CGRP as a ligand, receptor binding sites were demonstrated in the rat central nervous system. Saturation studies and Scatchard analysis of CGRP-binding to slide mounted tissue sections containing primarily cerebellum showed a single class of receptors with a dissociation...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(85)90331-6
更新日期:1985-09-01 00:00:00
abstract::We studied the effects of calcitonin gene-related peptide (CGRP) on ciliary beat frequency (CBF) and electrical properties of canine tracheal epithelium by a photoelectric method and Ussing's short-circuit technique, respectively. CGRP dose dependently increased CBF, an effect that was accompanied by elevation of intr...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(89)90183-6
更新日期:1989-09-01 00:00:00