Abstract:
:Neurotensin (NT) is a tridecapeptide (less than Glu-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Tyr-Ile-Leu-OH). It has been suggested that the naturally occurring neurotensin in (Gln4)-NT and that it can be hydrolysed to (Glu4)-NT during extraction. The aim of the present study was to determine whether the neurotensin found in human and rat plasma after fat ingestion is (Gln4)-NT or (Glu4)-NT. Two neurotensin antisera are described that have high avidity for (Glu4)-NT but low avidity for (Gln4)-NT. (Gln4)-NT could be separated from (Glu4)-NT by ion-exchange chromatography. The plasma samples were analyzed without prior extraction to avoid hydrolysis of the naturally occurring peptide. The results indicate that neurotensin in unextracted human and rat plasma is present as (Glu4)-NT, as originally proposed by Carraway and Leeman [4].
journal_name
Peptidesjournal_title
Peptidesauthors
Theodorsson-Norheim Edoi
10.1016/0196-9781(83)90060-8subject
Has Abstractpub_date
1983-07-01 00:00:00pages
543-7issue
4eissn
0196-9781issn
1873-5169pii
0196-9781(83)90060-8journal_volume
4pub_type
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