Neuropeptide Y-induced angiogenesis in aging.

abstract：:The role of muscarinic receptor subtype(s) in the control of gastric phase III contractions and motilin release was determined in dogs. Pirenzepine (226 nmol/kg/h) shortened the phase III cycle, causing an early increase in plasma motilin concentrations. Both AF-DX116BS and 4-DAMP inhibited the occurrence of spontaneo...

journal_title：Peptides

authors： Yamada T,Mizumoto A,Satoh M,Haga N,Itoh Z

更新日期：1997-01-01 00:00:00

abstract：:Many scorpion toxins that act on sodium channels (NaScTxs) have been characterized till date. These toxins may act modulating the inactivation or the activation of sodium channels and are named α- or β-types, respectively. Some venom toxins from Tityus obscurus (Buthidae), a scorpion widely distributed in the Brazilia...

journal_title：Peptides

authors： Duque HM,Mourão CBF,Tibery DV,Barbosa EA,Campos LA,Schwartz EF

更新日期：2017-09-01 00:00:00

abstract：:The effects of acute and subchronic administration of chlordiazepoxide (CDZ) on [3H][3-methyl-histidyl2]thyrotropin-releasing hormone binding to thyrotropin-releasing hormone (TRH) receptors in membrane preparations from various regions of rat brain were examined. Acute administration of CDZ (50 mg/kg x 3 within 24 h)...

journal_title：Peptides

authors： Shimoda K,Mason GA,Walker CH,Garbutt JC,Prange AJ Jr

更新日期：1991-01-01 00:00:00

abstract：:Vestibular compensation is a process of CNS plasticity that is correlated to a return of resting activity in medial vestibular nucleus (MVN) neurons ipsilateral to a peripheral vestibular deafferentation. Systemic administration of melanocortin peptides accelerates the compensation process; the ACTH/MSH(4-9) analogue,...

journal_title：Peptides

authors： Gilchrist DP,Darlington CL,Smith PF

更新日期：1996-01-01 00:00:00

abstract：:GIP receptor knockout mice were shown to be protected from the development of obesity on a high fat diet, suggesting a role of GIP in the development of obesity. In our study we aimed to test the hypothesis if excess of GIP could accelerate development of obesity and to identify GIP gene targets in adipose tissue. The...

journal_title：Peptides

authors： Szalowska E,Meijer K,Kloosterhuis N,Razaee F,Priebe M,Vonk RJ

更新日期：2011-05-01 00:00:00

abstract：:Angiotensin-(1-7) [Ang-(1-7)] develops its functions interacting with Mas receptor. Mas receptor was recently identified in the DRG and its activation by Ang-(1-7) resulted in peripheral antinociception against PGE2 hyperalgesia in an opioid-independent pathway. Nevertheless, the mechanism by which Ang-(1-7) induce pe...

journal_title：Peptides

authors： Castor MG,Santos RA,Duarte ID,Romero TR

更新日期：2015-07-01 00:00:00

abstract：:Urotensin-II (U-II), a ligand for the G-protein-coupled receptor UT, has been characterized as the most potent mammalian vasoconstrictor identified to date. Although circulating levels of U-II are altered in lower species (e.g., fish) upon exposure to hypo-osmotic stress, little is known about the actions of this cycl...

journal_title：Peptides

authors： Disa J,Floyd LE,Edwards RM,Douglas SA,Aiyar NV

更新日期：2006-06-01 00:00:00

abstract：:Neuropeptide S (NPS) produces several biological actions by activating a formerly orphan GPCR, now named NPS receptor (NPSR). It has been previously demonstrated that NPS stimulates murine leukocyte chemotaxis in vitro. In the present study we investigated the ability of NPS, in comparison with the proinflammatory pep...

journal_title：Peptides

authors： Filaferro M,Novi C,Ruggieri V,Genedani S,Alboni S,Malagoli D,Caló G,Guerrini R,Vitale G

更新日期：2013-01-01 00:00:00

abstract：:Huwentoxin-I (HWTX-I) is a 33-residue peptide isolated from the venom of Ornithoctonus huwena and could inhibit TTX-sensitive voltage-gated sodium channels and N-type calcium channels in mammalian dorsal root ganglion (DRG) neurons. However, the effects of HWTX-I on mammalian central neuronal and insect sodium channel...

journal_title：Peptides

authors： Wang M,Rong M,Xiao Y,Liang S

更新日期：2012-03-01 00:00:00

abstract：:The synthesis, purification, and characterization of biotinylated analogues of motilin are reported. The C-terminal of canine motilin was extended by the addition of a cysteine residue, and then biotinylated. Biotinyl motilin was purified by following HPLC and characterized by amino acid analysis. Biotinylation of the...

journal_title：Peptides

authors： Sakai T,Satoh M,Hayashi H,Fujikura K,Sano I,Koyama H,Tatemoto K,Itoh Z

更新日期：1994-01-01 00:00:00

abstract：:A short neuropeptide F (sNPF) precursor and a sNPF receptor (sNPFR) were characterized for the mosquito, Anopheles gambiae. The sNPFR was expressed in CHO-K1 cells, and it exhibited high affinity binding, IC(50) approximately 3-5 nM, for specific sNPFs. sNPF1 potently inhibited forskolin-stimulated cAMP production by ...

journal_title：Peptides

authors： Garczynski SF,Crim JW,Brown MR

更新日期：2007-01-01 00:00:00

abstract：:The incretin hormones, glucose dependent insulinotropic polypeptide (GIP) and glucagon-like peptide 1 (GLP-1), potentiate insulin secretion and are responsible for the majority of insulin secretion that occurs after a meal. They may also, however, have a fundamental role in pancreatic beta cell development and functio...

journal_title：Peptides

authors： Omar B,Ahlkvist L,Yamada Y,Seino Y,Ahrén B

更新日期：2016-05-01 00:00:00

abstract：:Both diapause hormone (DH) and ecdysone (E) are capable of terminating pupal diapause in members of the Helicoverpa/Heliothis complex. In this study we examine how the transcript encoding prothoracicotropic hormone (PTTH), the neuropeptide that stimulates the prothoracic gland to produce E, and the transcript encoding...

journal_title：Peptides

authors： Zhang Q,Denlinger DL

更新日期：2012-03-01 00:00:00

abstract：:Effects of rat and human calcitonin gene-related peptide (r alpha CGRP and h beta CGRP, respectively) upon uterine contractile force were investigated using uterine horns from nonpregnant rats, r alpha CGRP and h beta CGRP were equipotent (pD2 = 8.85-9.09) in inhibiting spontaneous and electrically evoked uterine cont...

journal_title：Peptides

authors： Pennefather JN,Reynoldson NA,Handberg GM

更新日期：1990-09-01 00:00:00

abstract：:The aim of our study was to determine whether a meal modifies the antisecretory response induced by PYY and the structural requirements to elicit antisecretory effects of analogue PYY(22-36) for potential antidiarrhea therapy. The variations in short-circuit current (Isc) due to the modification of ionic transport acr...

journal_title：Peptides

authors： Eto B,Boisset M,Eden P,Balasubramaniam A,Desjeux JF

更新日期：1995-01-01 00:00:00

abstract：:Male Holtzman albino and Long-Evans hooded rats were administered one microgram of arginine vasopressin (AVP) or a placebo each day after the acquisition trials of a visual white-black discrimination. Animals were then trained in the reversal of the discrimination. Performance was assessed by the number of trials to c...

journal_title：Peptides

authors： Tinius TP,Beckwith BE,Oltmanns D

更新日期：1989-01-01 00:00:00

abstract：:Antimicrobial peptides produced by multicellular organisms protect against pathogenic microorganisms, whereas such peptides produced by bacteria provide an ecological advantage over competitors. Certain antimicrobial peptides of metazoan origin are also toxic to eukaryotic cells, with preference for a variety of cance...

journal_title：Peptides

authors： Sand SL,Oppegård C,Ohara S,Iijima T,Naderi S,Blomhoff HK,Nissen-Meyer J,Sand O

更新日期：2010-07-01 00:00:00

abstract：:The intracranial injection of an opioid antagonist (naloxone) caused aggregation of xanthophores in goldfish scales. This aggregating effect produced by naloxone was inhibited by an injection of methionine-enkephalin (M-ENK). M-ENK, when injected together with melatonin which normally produces aggregation of xanthopho...

journal_title：Peptides

authors： Satake N

更新日期：1980-04-01 00:00:00

abstract：:The evolution, function and interaction of ligand-receptor pairs are of major pharmaceutical interest. Comparative sequence analysis approaches using data from phylogenetically distant organisms can provide insights into their origin and possible physiological roles. The present review focuses on the pituitary adenyla...

journal_title：Peptides

authors： Cardoso JC,Vieira FA,Gomes AS,Power DM

更新日期：2007-09-01 00:00:00

abstract：:Recent studies have identified compounds with reduced efficacy relative to nociceptin/orphanin FQ at the opioid-like receptor ORL1. Utilizing stimulation of [(35)S]GTPgammaS binding as in vitro assays, it was determined that both [Phe(1)psi(CH(2)-NH)Gly(2)]N/OFQ(1-13)NH(2) and the hexapeptide Ac-RYYRIK-NH(2) act as pa...

journal_title：Peptides

authors： Burnside JL,Rodriguez L,Toll L

更新日期：2000-07-01 00:00:00

abstract：:Three neurotensin (NT) receptors have been cloned to date, two of which, NTS1 and NTS2, belong to the family of seven transmembrane domain receptors coupled to G proteins (GPCRs). NTS1 and NTS2 may activate multiple signal transduction pathways, involving several G proteins. However, whereas NT acts as an agonist towa...

journal_title：Peptides

authors： Pelaprat D

更新日期：2006-10-01 00:00:00

abstract：:Food deprivation inhibits estrous behavior in several species of rodents, but little is known about the neurotransmitter systems mediating this phenomenon. We determined whether partial blockade of opioid receptors by continuous infusion of naltrexone and/or acute peripheral injection of cholecystokinin (CCK) administ...

journal_title：Peptides

authors： Jones JE,Corp ES,Wade GN

更新日期：2001-04-01 00:00:00

abstract：:The very first step in the study of the endocrine control of insect molting was taken in 1922. Stefan Kopec characterized a factor in the brain of the gypsy moth, Lymantria dispar which appeared to be essential for metamorphosis. This factor was later identified as the neuropeptide prothoracicotropic hormone (PTTH), t...

journal_title：Peptides

authors： Marchal E,Vandersmissen HP,Badisco L,Van de Velde S,Verlinden H,Iga M,Van Wielendaele P,Huybrechts R,Simonet G,Smagghe G,Vanden Broeck J

更新日期：2010-03-01 00:00:00

abstract：:The neuropharmacological basis for d-amphetamine induced paradoxical behavioral thermoregulation remains unclear. This study examined thermoregulatory behavior of rats in a runway device that housed a heat source at one end and in which locomotion along the length of the runway could be observed. Sprague Dawley rats w...

journal_title：Peptides

authors： Yehuda S,Sheleff P

更新日期：1985-03-01 00:00:00

abstract：:A novel conotoxin, pc16a, was isolated from the venom of Conus pictus. This is the first peptide characterized from this South-African cone snail and it has only 11 amino acid residues, SCSCKRNFLCC*, with the rare cysteine framework XVI and a monoisotopic mass of 1257.6Da. Two peptides were synthesized with two possib...

journal_title：Peptides

authors： Van Der Haegen A,Peigneur S,Dyubankova N,Möller C,Marí F,Diego-García E,Naudé R,Lescrinier E,Herdewijn P,Tytgat J

更新日期：2012-03-01 00:00:00

abstract：:Endothelin (ET)-1 is an important peptide in cancer progression stimulating cellular proliferation, tumor angiogenesis and metastasis. ET-1 binds with high affinity to the ETA receptor (R) and ETBR on cancer cells. High levels of tumor ET-1 and ETAR are associated with poor survival of lung cancer patients. Here the e...

journal_title：Peptides

authors： Moody TW,Ramos-Alvarez I,Moreno P,Mantey SA,Ridnour L,Wink D,Jensen RT

更新日期：2017-04-01 00:00:00

abstract：:Peptides may act through G protein-coupled receptors to influence cardiovascular performance; thus, delineating mechanisms involved in signaling is a molecular-based strategy to influence health. Molecular switches, often represented by conserved motifs, maintain a receptor in an inactive state. However, once the swit...

journal_title：Peptides

authors： Rasmussen M,Leander M,Ons S,Nichols R

更新日期：2015-09-01 00:00:00

abstract：:Neurotensin(6-13) has been isolated and sequenced as the major form of neurotensin-like immunoreactivity (NTLI) in a human hepatic fibrolamellar carcinoma. Circulating NTLI in the patient, especially C-terminal, was very high. In additional studies, NT(6-13) was synthesized and compared with the purified tumor NTLI by...

journal_title：Peptides

authors： Read D,Shulkes A,Fernley R,Simpson R

更新日期：1991-07-01 00:00:00

abstract：:Urinary tract infections (UTI) are important health problems and predisposing causes of UTI are not entirely known. Neuro-immune interactions play an important role in human health and disease. Capsaicin-sensitive sensory nerves which in nerve bladder extensively regulate immune system through neuropeptides such as su...

journal_title：Peptides

authors： Altuntaş SÇ,Ipekçi T,Yakupoğlu G,Erin N

更新日期：2014-06-01 00:00:00

abstract：:The occurrence of neuropeptides in the frontal ganglia of larvae of the tobacco hawkmoth, Manduca sexta, the tomato moth, Lacanobia oleracea and the cotton leafworm, Spodoptera littoralis was investigated using reversed-phase high performance liquid chromatography (RP-HPLC), matrix-assisted laser desorption time of fl...

journal_title：Peptides

authors： Audsley N,Matthews J,Weaver RJ

更新日期：2005-01-01 00:00:00