Abstract：
:Food deprivation inhibits estrous behavior in several species of rodents, but little is known about the neurotransmitter systems mediating this phenomenon. We determined whether partial blockade of opioid receptors by continuous infusion of naltrexone and/or acute peripheral injection of cholecystokinin (CCK) administration would overcome the suppressive effects of food deprivation on estrous behavior in Syrian hamsters. Contrary to expectation, naltrexone produced a slight suppression of estrous behavior, and systemic CCK administration had no effect. This dose of naltrexone was sufficient to reduce in vivo binding of [(3)H]naloxone in the brain, and both compounds affected other parameters such as food intake and body weight gain. Thus, the doses of CCK and naltrexone that were used were physiologically effective. These findings suggest that neither peripheral CCK nor opioid systems are likely to play a major role in the suppression of hamster estrous behavior by food deprivation.
journal_name
Peptidesjournal_title
Peptidesauthors
Jones JE,Corp ES,Wade GNdoi
10.1016/s0196-9781(01)00370-9subject
Has Abstractpub_date
2001-04-01 00:00:00pages
601-6issue
4eissn
0196-9781issn
1873-5169pii
S0196-9781(01)00370-9journal_volume
22pub_type
杂志文章相关文献
PEPTIDES文献大全abstract：:Expression of the two gonadotropin-releasing hormone homologue peptides GnRHI and GnRHII and their receptor GnRHR has been demonstrated in a number of malignancies. In hormone-dependent breast cancer, GnRH analogs are used for therapy in premenopausal women. Gene expression of GnRHI, II and R was studied in breast bio...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2012.12.016
更新日期：2013-04-01 00:00:00
abstract：:Vasopressin is one of the key regulators of the body's water and solute balance. When this balance is pathologically disturbed, determination of serum vasopressin concentrations might be a helpful tool for guiding therapy. However, due to its instability and considerable association to platelets, reliable measurement ...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2005.04.019
更新日期：2005-12-01 00:00:00
abstract：:The thyroid gland is known to harbor cholinergic and VIPergic nerves. In the present study, the influences of cholinergic stimulation by carbachol, cholinergic blockade by methylatropine and stimulation with various VIP sequences on basal, TSH-induced and VIP-induced thyroid hormone section were investigated in vivo i...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(85)90157-3
更新日期：1985-07-01 00:00:00
abstract：:The binding of monoiodo 125I-Trp11-neurotensin to purified rat gastric fundus smooth muscle plasma membranes was characterized. Specific binding of ligand in subcellular fractions from rat fundus smooth muscle showed a distribution that paralleled that of several plasma membrane marker enzymes. 125I-Trp11-neurotensin ...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(84)90117-7
更新日期：1984-09-01 00:00:00
abstract：:Kisspeptins are biologically active cleavage peptides of the KiSS-1 gene products with important roles in the suppression of tumor metastasis and in the reproduction. The aim of the present study is to clarify changes of the expression of kisspeptins and kisspeptin receptor in the kidney with and without chronic renal...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2010.07.001
更新日期：2010-10-01 00:00:00
abstract：:Malondialdehyde-modified low-density lipoprotein (MDA-LDL) is recognized as a surrogate marker of lipid oxidation and is associated with arteriosclerosis. However, there are limited reports on the relationship between heart failure and MDA-LDL. Therefore, we aimed to determine whether MDA-LDL is activated in patients w...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2020.170421
更新日期：2021-01-01 00:00:00
abstract：:The melanocortin system has been implicated in a multitude of physiological pathways including obesity, satiety, energy homeostasis, sexual behavior, pigmentation, sodium regulation, hypertension, and many others. Based upon studies of the endogenous melanocortin receptor agonists at the cloned human melanocortin rece...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2010.08.025
更新日期：2010-12-01 00:00:00
abstract：:We investigated the ability of sulfated cholecystokinin (26-33) (CCK-8) and cholecystokinin (30-33) (CCK-4) to induce taste aversion or avoidance conditioning (TAC) in a one-bottle testing paradigm after either intravenous (i.v.), intracerebroventricular (i.c.v.), or intraperitoneal (i.p.) administration. Significant ...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/s0196-9781(98)00025-4
更新日期：1998-01-01 00:00:00
abstract：:We have developed a specific and sensitive radioimmunoassay for the hydra head activator neuropeptide (HHAP). The antibody recognizes the C-terminal portion of HHAP and shows no cross-reactivity with other neuropeptides. The assay allows measurement of HHAP-like material in tissue extracts with a minimum detectable co...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(90)90081-f
更新日期：1990-03-01 00:00:00
abstract：:The discovery of several adipokines with diverse activities and their involvement in regulation of various pathophysiological functions of human body has challenged the researchers. In the family of adipokine, chemerin is a novel and unique addition. Ever since the first report on chemerin as a chemo-attractant protei...
journal_title：Peptides
pub_type： 杂志文章,评审
doi：10.1016/j.peptides.2014.09.019
更新日期：2014-12-01 00:00:00
abstract：:Effective management of chronic pain is demanded by ethical as well as medical considerations. Although opioid analgesics remain among the most effective pharmacotherapies for ameliorating many types of pain, their use is clouded by concerns regarding their addictive properties, underscored by the current epidemic of ...
journal_title：Peptides
pub_type： 杂志文章,评审
doi：10.1016/j.peptides.2018.12.002
更新日期：2019-02-01 00:00:00
abstract：:Peptides have the potential to be potent pharmaceutical agents for the treatment of many central nervous system derived maladies. Unfortunately peptides are generally water-soluble compounds that will not enter the central nervous system, via passive diffusion, due to the existence of the blood-brain barrier. Peptides...
journal_title：Peptides
pub_type： 杂志文章,评审
doi：10.1016/s0196-9781(01)00537-x
更新日期：2001-12-01 00:00:00
abstract：:Mustard oil, which stimulates small diameter afferents, was used to evoke the expression of the oncogene c-fos in the lumbar spinal cord. C-fos-like immunoreactivity was concentrated in, but not limited to, neuronal nuclei of laminae I and II of the lumbar dorsal horn. Double-label immunocytochemistry was used to dete...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(91)90202-z
更新日期：1991-11-01 00:00:00
abstract：:Opiate alkaloids and opioid peptides have been shown to suppress plasma LH and FSH levels via a naloxone sensitive mechanism in several species including man. Three subtypes of opiate receptors have been characterized: mu, delta and kappa. The present study was designed to investigate their role in gonadotropin releas...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(83)90012-8
更新日期：1983-09-01 00:00:00
abstract：:The multifunctional arthropod 'insect kinins' share the evolutionarily conserved C-terminal pentapeptide motif Phe-X1-X2-Trp-Gly-NH2, where X1=His, Asn, Ser, or Tyr and X2=Ser, Pro, or Ala. Eight different analogs of the insect kinin C-terminal pentapeptide active core in which the critical residues Phe 1, Pro3 and Tr...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2007.07.034
更新日期：2008-02-01 00:00:00
abstract：:A non-enkephalin containing pentadeca peptide derived from ovine adrenal proenkephalin has been purified and sequenced. The sequence of the peptide is: Phe-Ala-Glu-Pro-Leu-Pro-Ser-Glu-Glu-Glu-Gly-Glu-Ser-Tyr-Ser (preproenkephalin 237-251) representing the amino portion of peptide B (preproenkephalin 237-268). The sequ...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(84)90105-0
更新日期：1984-09-01 00:00:00
abstract：:In this study, we evaluated the bradykinin potentiating activity and ACE inhibitory activity of several Ang-(1-7)-related peptides: Ang-(2-7), Ang-(3-7), Ang-(4-7), Ang-(1-6), Ang-(1-5) and the selective antagonist of Ang-(1-7): D-[Ala7]Ang-(1-7) (A-779). In vivo experiments were performed in freely moving Wistar rats...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/s0196-9781(99)00031-5
更新日期：1999-01-01 00:00:00
abstract：:Cellular uptake of [125I] labelled DSIP at the luminal interface of the blood-brain barrier (BBB) was studied in the ipsilateral perfused in situ guinea pig forebrain. Regional unidirectional transfer constants (Kin) calculated from the multiple-time brain uptake analysis were 0.93, 1.33 and 1.66 microliter.min-1 g-1 ...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(89)90026-0
更新日期：1989-03-01 00:00:00
abstract：:Using a biologically active radioligand, [Tyr(125I)10]VIP, we have identified and characterized receptors for vasoactive intestinal peptide (VIP) on membranes prepared from the rat superior mesenteric artery and bovine coronary arteries. Binding was specific, saturable, reversible and dependent on time and temperature...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(87)90013-1
更新日期：1987-05-01 00:00:00
abstract：:Angiotensin (Ang)--a peptide that is part of the renin-angiotensin system-induces vasoconstriction and a subsequent increase in blood pressure; Ang peptides, especially AngII, can also act as potent pro-inflammatory mediators. Platelet-activating factor (PAF) is a potent phospholipid mediator that is implicated in man...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2015.09.002
更新日期：2015-11-01 00:00:00
abstract：:The emergence of multidrug-resistant strains of Neisseria gonorrhoeae constitutes a serious threat to public health and necessitates the discovery of new types of antimicrobial agents. Among the 18 clinical isolates of N. gonorrhoeae with susceptible to spectinomycin, ceftriaxone and cefixime, 14 isolates were resista...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2013.10.020
更新日期：2014-03-01 00:00:00
abstract：:High levels of neuropeptide Y (NPY) are found in the hypothalamus, median eminence, pituitary portal blood, and the pituitary in a number of species. Neuropeptide Y may influence the synthesis and secretion of a variety of hormones by interacting with specific receptors in the hypothalamus and/or the pituitary. To fur...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(94)90090-6
更新日期：1994-01-01 00:00:00
abstract：:The hypocretins (1 and 2) have emerged as key regulators of sleep and wakefulness. We developed a high-throughput enzyme immunoassay (EIA) to measure total brain hypocretin levels from large numbers of mice. Hypocretin levels were not altered by circadian time or age. However, significant differences in one or both hy...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/s0196-9781(02)00251-6
更新日期：2002-12-01 00:00:00
abstract：:This paper reports the purification and biochemical/pharmacological characterization of two myotoxic phospholipases A(2) (PLA(2)s) from Bothrops brazili venom, a native snake from Brazil. Both myotoxins (MTX-I and II) were purified by a single chromatographic step on a CM-Sepharose ion-exchange column up to a high pur...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2008.05.021
更新日期：2008-10-01 00:00:00
abstract：:The distribution of the VIP containing structures was studied in the gut and in the paravertebral sympathetic ganglia of the quail and chick embryos by immunocytochemistry. In the gut, development of peptidergic nerves followed a craniocaudal gradient. Immunoreactive fibres were first visible in the oesophagus at day ...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(84)90206-7
更新日期：1984-03-01 00:00:00
abstract：:A myomodulin peptide has been suggested to mediate the response of the giant glial cells to stimulation of the Leydig interneuron in the central nervous system of the leech Hirudo medicinalis [Eur. J. Neurosci. 11 (1999) 3125]. We have now studied the glial response to the endogenous leech MM peptide (GMGALRL-NH(2), M...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/s0196-9781(02)00255-3
更新日期：2002-12-01 00:00:00
abstract：:Growing evidence suggests that the neuropeptide Y (NPY) system plays an important role in the immune system. Yet, little is known about the expression of NPY and receptors in the immune system. Moreover, original contradicting results have confused the picture and hampered a clear understanding of its role in the immu...
journal_title：Peptides
pub_type： 杂志文章,评审
doi：10.1016/j.peptides.2006.09.030
更新日期：2007-02-01 00:00:00
abstract：:During a systemic search for peptides that possess the C-terminal amide structure, a novel heptapeptide with isoleucine amide was isolated from bovine serum by sequential steps of reversed phase HPLC. Microsequence and amino acid analyses revealed the structure: Asp-Thr-His-Lys-Ser-Glu-Ile-NH2. Since this peptide has ...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(91)90031-j
更新日期：1991-03-01 00:00:00
abstract：:Energy homeostasis is controlled by a complex neuroendocrine system consisting of peripheral signals like leptin and central signals, in particular, neuropeptides. Several neuropeptides with anorexigenic (POMC, CART, and CRH) as well as orexigenic (NPY, AgRP, and MCH) actions are involved in this complex (partly redun...
journal_title：Peptides
pub_type： 杂志文章,评审
doi：10.1016/s0196-9781(02)00269-3
更新日期：2002-12-01 00:00:00
abstract：:The effects of atrial natriuretic factor (ANF) on [3H]norepinephrine ([3H]NE) release evoked by a sodium-free medium (SFM) were studied. Experiments were performed in rat adrenal medulla slices incubated in vitro. Results showed that [3H]NE release evoked by the omission of Na+ was decreased by 10 nM ANF. In addition,...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(94)90100-7
更新日期：1994-01-01 00:00:00
