Abstract：
:Opiate alkaloids and opioid peptides have been shown to suppress plasma LH and FSH levels via a naloxone sensitive mechanism in several species including man. Three subtypes of opiate receptors have been characterized: mu, delta and kappa. The present study was designed to investigate their role in gonadotropin release. Three highly selective opioid ligands, DAGO, MRZ and DTE12 (a dimeric tetrapeptide enkephalin), were injected intraventricularly into chronically ovariectomized rats. Injection of the mu-agonist at doses of 1 and 10 nmol produced a significant suppression of LH secretion, while the delta- and kappa-agonists had no significant effect. Thus, the mu-receptor seems to be the primary opiate receptor involved in the regulation of LH secretion. None of the opiate agonists employed had an effect on FSH secretion.
journal_name
Peptidesjournal_title
Peptidesauthors
Pfeiffer DG,Pfeiffer A,Shimohigashi Y,Merriam GR,Loriaux DLdoi
10.1016/0196-9781(83)90012-8subject
Has Abstractpub_date
1983-09-01 00:00:00pages
647-9issue
5eissn
0196-9781issn
1873-5169pii
0196-9781(83)90012-8journal_volume
4pub_type
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