Abstract:
:Binding studies have shown that [125I]NKA is a selective ligand of tachykinin septide-sensitive binding sites from membranes of the rat submaxillary gland. Indeed, this ligand bound with high affinity to a single population of sites. In addition, competition studies indicated that natural tachykinins and tachykinin-related compounds had a similar affinity for these sites than for those labeled with [3H]ALIE-124, a selective ligand of septide-sensitive binding sites. Moreover, selective tachykinin NK2, or NK3 agonists or antagonists exhibited weak or no affinity for [125I]NKA binding sites. As indicated by Ki values of several compounds, the pharmacological characteristics of the septide-sensitive binding sites (labeled with [125I]NKA) largely differ from those of classic NK1 binding sites, as determined on crude synaptosomes from the rat brain using [125I]Bolton-Hunter substance P (SP) as ligand. Indeed, several tachykinins including neurokinin A (NKA), neuropeptide K (NPK), neuropeptide gamma (NKgamma), and neurokinin B, as well as some SP and NKA analogues or C-terminal fragments such as septide, ALIE-124, SP(6-11), NKA(4-10), which have a weak affinity for classic tachykinin NK1 binding sites exhibited a high affinity for the septide-sensitive binding sites. In contrast, SP, classic selective NK1 agonists, and antagonists had a high affinity for both types of binding sites. The presence of a large population of tachykinin septide-sensitive binding sites in the rat submaxillary gland may thus explain why NPK and NPgamma induce salivary secretion and may potentiate the SP-evoked response in spite of the absence of tachykinin NK2 receptors in this tissue.
journal_name
Peptidesjournal_title
Peptidesauthors
Beaujouan JC,Saffroy M,Torrens Y,Sagan S,Glowinski Jdoi
10.1016/s0196-9781(99)00140-0subject
Has Abstractpub_date
1999-11-01 00:00:00pages
1347-52issue
11eissn
0196-9781issn
1873-5169pii
S0196-9781(99)00140-0journal_volume
20pub_type
杂志文章相关文献
PEPTIDES文献大全abstract::Urotensin-II (U-II), a ligand for the G-protein-coupled receptor UT, has been characterized as the most potent mammalian vasoconstrictor identified to date. Although circulating levels of U-II are altered in lower species (e.g., fish) upon exposure to hypo-osmotic stress, little is known about the actions of this cycl...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2005.10.004
更新日期:2006-06-01 00:00:00
abstract::WH1fungin, a surfactin cyclopeptide from Bacillus amyloliquefaciens WH1, is firstly reported as a novel immunoadjuvant, which can markedly enhance the immune response when given in mixture with antigens. After intramuscular or subcutaneous immunization, WH1fungin can help to induce both of durable humoral and cellular...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2012.08.021
更新日期:2012-11-01 00:00:00
abstract::Higher plasma copeptin level has been associated with poor outcomes of critical illness. The present study was undertaken to investigate the plasma copeptin concentrations in children with traumatic brain injury (TBI) and to analyze the correlation of copeptin with disease outcome. Plasma copeptin concentrations of 12...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2013.01.015
更新日期:2013-04-01 00:00:00
abstract::The proteolytic conversion of oxytocin and vasopressin by purified rat brain synaptic membranes was studied at 37 degrees C and physiological pH 7.4. The formed peptide fragments were isolated by high performance liquid chromatography and characterized by amino acid analysis. When oxytocin was incubated with synaptic ...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(91)90068-z
更新日期:1991-09-01 00:00:00
abstract::The effects of intracerebroventricular (ICV) and intravenous injections of bombesin (BBS) on food intake were investigated in turkeys. Adult turkey hens were injected ICV with 50 to 1000 ng of BBS. In addition, the effect of pretreatment with the BBS antagonist [d-Arg1, D-Phe5, D-Trp7,9, Leu11]-substance P was investi...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(89)90030-2
更新日期:1989-03-01 00:00:00
abstract::Higher levels of natriuretic peptides were identified in outpatients after myocardial infarction (MI) compared to the healthy population, even in the absence of heart failure (HF). Therefore, we assessed the optimal cut-off value of B-type natriuretic peptide (BNP) in relation to new-onset HF prediction in 79 post-MI ...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2010.06.023
更新日期:2010-10-01 00:00:00
abstract::Humanin (HN) and its analogues have been shown to protect cells against death induced by various Alzheimer's disease (AD) genes and amyloid-beta-peptides in vitro; the analogues [Gly(14)]-HN and colivelin have also been shown to be potent in reversing learning and memory impairment induced by scopolamine or quinuclidi...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2008.06.019
更新日期:2008-11-01 00:00:00
abstract::I.c.v. injection for 9 days of either naltexone (NTX) (5, 10, 20, 40 micrograms/rat) or a selective mu peptide (CTOP) (0.125, 0.25, 0.5, 1, 3, 6 micrograms/rat) or delta (naltrindole) (NLT) (5, 10, 20 micrograms/rat) subtype opioid receptor antagonist affected sensitization to cocaine (COC) (50 mg/kg, i.p.) administer...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(97)00182-4
更新日期:1997-01-01 00:00:00
abstract::A bradykinin (BK)-related peptide was isolated from heat-denaturated plasma from an elasmobranch fish, the little skate, Leucoraja erinacea after incubation with porcine pancreatic kallikrein. The primary structure of the peptide (H-Gly-Ile-Thr-Ser-Trp-Leu-Pro-Phe-OH; skate BK) shows limited structural similarity to t...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2008.04.006
更新日期:2008-08-01 00:00:00
abstract::beta-Lactotensin (beta-LT) is a bioactive peptide derived from bovine milk beta-lactoglobulin and is a natural ligand for neurotensin receptors. We examined the effect of beta-LT on restraint stress and fear memory in mice. Mice subjected to acute restraint stress exhibited a decreased number of head-dips and increase...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2006.08.009
更新日期:2006-12-01 00:00:00
abstract::We investigated the effect of synthetic antimicrobial decapeptide KSL-W (KKVVFWVKFK) on normal human gingival fibroblast growth, migration, collagen gel contraction, and α-smooth muscle actin protein expression. Results show that in addition to promoting fibroblast adhesion by increasing F-actin production, peptide KS...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2017.05.003
更新日期:2017-07-01 00:00:00
abstract::Intracerebroventricular administration of NPY suppresses ethanol intake in selectively bred alcohol-preferring rat lines, but not in rats selectively bred for low ethanol drinking or in unselected Wistar rats, when access to ethanol is limited to 2h/day. However, when rats undergo chronic (24h/day) ethanol drinking (o...
journal_title:Peptides
pub_type: 杂志文章,评审
doi:10.1016/j.peptides.2006.07.028
更新日期:2007-02-01 00:00:00
abstract::Angiotensin(1-7) had a compound effect on blood pressure of pithed Sprague-Dawley rats. The initial phase of the response consisted of an increase in MAP of short duration and independent of injected dose, followed by a decline of arterial pressure to values below baseline. Both the magnitude (range: -4 +/- 1 to -13 +...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(93)90097-z
更新日期:1993-07-01 00:00:00
abstract::The purpose of this study is to elucidate the mechanism of action and site of action of calcitonin gene-related peptide (CGRP) and its effects on calcium concentrations in two types of cardiomyocytes, neonatal and adult, by employing real-time fluorescence imaging. CGRP caused an increase in intramyocytic calcium with...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2005.04.021
更新日期:2005-11-01 00:00:00
abstract::Japonicin-1 (FFPIGVFCKIFKTC) and japonicin-2 (FGLPMLSILPKALCILLKRKC), two peptides with differential growth-inhibitory activity against the Gram-negative bacterium, Escherichia coli and the Gram-positive bacterium Staphylococcus aureus, were isolated from an extract of the skin of the Japanese brown frog Rana japonica...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(01)00634-9
更新日期:2002-03-01 00:00:00
abstract::To investigate the contribution of the N-terminal sequence of h-EGF to its biological activity and the formation of three intramolecular disulfide bonds by oxidative refolding via air oxidation, five derivatives of h-EGF with a single N-terminal amino acid deletion were synthesized by solid-phase synthesis. The homoge...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(94)00181-2
更新日期:1995-01-01 00:00:00
abstract::We show here that crotamine, a polypeptide from the South American rattlesnake venom with cell penetrating and selective anti-fungal and anti-tumoral properties, presents a potent anti-plasmodial activity in culture. Crotamine inhibits the development of the Plasmodium falciparum parasites in a dose-dependent manner [...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2016.01.013
更新日期:2016-04-01 00:00:00
abstract::An antifungal peptide with a molecular mass of 9412 and an N-terminal sequence exhibiting notable homology to those of lipid transfer proteins was isolated from seeds of the vegetable Brassica campestris. The purification protocol entailed ion exchange chromatography on Q-Sepharose, affinity chromatography on Affi-gel...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2007.06.028
更新日期:2007-08-01 00:00:00
abstract::Vasoactive intestinal peptide (VIP) is a neuropeptide present in high concentrations in the hippocampus. The studies reported here demonstrate that VIP administered into the third ventricle of the brain caused amnesia in mice trained on a left-right footshock avoidance task in a T-maze. VIP resulted in amnesia when ad...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(90)90012-t
更新日期:1990-09-01 00:00:00
abstract::The study was undertaken to investigate the oxidation and reduction of cholecystokinin (CCK) both as pure standards and as endogenous porcine peptides. Furthermore an attempt was made to prevent oxidation of the endogenous porcine peptides in the extraction procedure. CCK-8 and CCK-33 standards were always oxidized in...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(85)90069-5
更新日期:1985-01-01 00:00:00
abstract::The biological activities of alpha-MSH des-acetyl MSH, gamma-MSH and LPH37-58 were compared using the Anolis rate method of bioassay. Dose-response data showed LPH37-58 to be equipotent with alpha-MSH, but des-acetyl MSH and gamma-MSH were found to be much less active. The effect of LPH37-58 was additive to that of al...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(82)90134-6
更新日期:1982-01-01 00:00:00
abstract::Elucidating how neuropeptides affect physiology may result in delineating peptidergic mechanisms and identifying antagonists for application in basic and translational science. Human neuropeptide Y (NPY) regulates cardiac activity; frequently invertebrates contain orthologs of vertebrate peptides. We report invertebra...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2012.01.005
更新日期:2012-02-01 00:00:00
abstract::One major cause for discrepancies in results from animal experimental studies is the use of different animal strains and suppliers. We have previously reported that Wistar rats from five different suppliers display profound differences in ethanol intake and behavior. One of the neurobiological processes that could be ...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2012.04.016
更新日期:2012-07-01 00:00:00
abstract::Immunocytochemistry using an antiserum to the C-terminal octapeptide of synenkephalin, proenkephalin(63-70), was performed throughout the rat brain and revealed numerous immunopositive fibers and some cell bodies. The morphology and distribution of synenkephalin immunoreactivity was extremely similar to that of a comm...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(89)90018-1
更新日期:1989-11-01 00:00:00
abstract::In an immunohistochemical study, a specific antiserum raised against [D-Ala2]deltorphin-I (DADTI), a highly selective ligand for delta opioid receptors, was used to demonstrate immunoreactive structures in the rat retina. [D-Ala2]Deltorphin-I immunoreactivity occurred in a subpopulation of the retinal amacrine cells s...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(94)90169-4
更新日期:1994-01-01 00:00:00
abstract::Although many studies have demonstrated the action of motilin on migrating motor complex by using human subjects and relatively large animals, the precise physiological mechanisms of motilin remain obscure. One reason for the lack of progress in this research field is that large animals are generally not suitable for ...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2008.10.006
更新日期:2009-02-01 00:00:00
abstract::Previous reports have demonstrated that systemic injection of cholecystokinin (CCK) in rats produces dose-related decreases in food intake, increases in neurohypophyseal secretion of oxytocin (OT), and decreases in gastric emptying. The present studies determined whether systemic injection of bombesin (BBS), another p...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(88)90194-5
更新日期:1988-11-01 00:00:00
abstract::To identify a minimal peptide ligand that participates in recognition of heparin, we synthesized peptides extending a 29-kDa fragment in the C-terminal heparin binding domain of fibronectin. We obtained evidence that two peptides (designated D5 and D1) exhibit inhibitory activity on binding of the 29-kDa fragment to h...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(96)00149-0
更新日期:1996-01-01 00:00:00
abstract::Effects of spantide ([D-Arg1,D-Trp7,9,Leu11]substance P) on coronary resistance vessels were studied in isolated guinea pig hearts perfused at constant rate with isotonic buffer containing 20 or 40 mM KCl. Spantide (1 microM) caused a 20-fold rightward shift of the substance P (SP) dose-response curve for vasodilation...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(91)90047-s
更新日期:1991-09-01 00:00:00
abstract::Neuropeptide FF (NPFF) has certain antiopiate actions and may play a role in opiate tolerance and dependence. Third ventricle injection of 10 micrograms NPFF induces a quasimorphine abstinence syndrome in opiate-naive rats. Nitric oxide synthesis may also contribute to opiate tolerance and dependence. The present stud...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(96)00035-6
更新日期:1996-01-01 00:00:00