Abstract:
:In an immunohistochemical study, a specific antiserum raised against [D-Ala2]deltorphin-I (DADTI), a highly selective ligand for delta opioid receptors, was used to demonstrate immunoreactive structures in the rat retina. [D-Ala2]Deltorphin-I immunoreactivity occurred in a subpopulation of the retinal amacrine cells situated in the inner nuclear layer. Their stained processes were mainly distributed in the sublaminae 1 and 3 of the inner plexiform layer. A few positive cells, probably displaced amacrine cells, were also seen in the ganglion cell layer. Double immunostaining revealed that 12.8% of DADTI-immunoreactive cells costored GABA and 27.7% costored neuropeptide Y, whereas only few DADTI-positive cells colocalized tyrosine hydroxylase (0.3%) and almost no other peptides. These findings suggest that some retinal amacrine cells possess DADTI-like molecule(s), possibly acting as neurotransmitter(s) or neuromodulator(s).
journal_name
Peptidesjournal_title
Peptidesauthors
Abe H,Tooyama I,Renda T,Erspamer V,Kimura Hdoi
10.1016/0196-9781(94)90169-4subject
Has Abstractpub_date
1994-01-01 00:00:00pages
49-54issue
1eissn
0196-9781issn
1873-5169pii
0196-9781(94)90169-4journal_volume
15pub_type
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