Effect of beta-lactotensin on acute stress and fear memory.

abstract：:The multifunctional arthropod 'insect kinins' share the evolutionarily conserved C-terminal pentapeptide motif Phe-X1-X2-Trp-Gly-NH2, where X1=His, Asn, Ser, or Tyr and X2=Ser, Pro, or Ala. Eight different analogs of the insect kinin C-terminal pentapeptide active core in which the critical residues Phe 1, Pro3 and Tr...

journal_title：Peptides

authors： Taneja-Bageshwar S,Strey A,Zubrzak P,Williams H,Reyes-Rangel G,Juaristi E,Pietrantonio P,Nachman RJ

更新日期：2008-02-01 00:00:00

abstract：:Effects of pentobarbital, chlordiazepoxide and ethanol were studied alone and in combination with thyrotropin-releasing hormone (TRH), IM, on punished behavior. Key-peck responses of pigeons were maintained by food presentation under a fixed-interval 3-min schedule in which every 30th response produced shock. Moderate...

journal_title：Peptides

authors： Witkin JM,Sickle J,Barrett JE

更新日期：1984-07-01 00:00:00

abstract：:As an attempt to approach the pathogenesis of peptic ulcer disease, antral gastrin and somatostatin concentrations were studied in normal subjects, patients with duodenal ulcer and gastric ulcer. In the patients with peptic ulcer, antral somatostatin concentrations were significantly lower than those in normal subject...

journal_title：Peptides

authors： Sumii K,Fukushima T,Hirata K,Matsumoto Y,Sanuki E,Tsumaru S,Sumioka M,Miyoshi A,Miyachi Y

更新日期：1981-01-01 00:00:00

abstract：:Metabolism of orphanin FQ/nociceptin (OFQ/N) was studied in the spinal cord of rats. The heptadecapeptide was efficiently cleaved by a neutral serine endopeptidase, thus releasing the major metabolite, OFQ/N(1-11), further truncated to the final product, OFQ/N(1-6). Biologic activity of this latter fragment was tested...

journal_title：Peptides

authors： Suder P,Kotlinska J,Smoluch MT,Sällberg M,Silberring J

更新日期：1999-01-01 00:00:00

abstract：:The in vivo effects of JMV-320 (a highly selective CCKB receptor ligand) and of CCK-4 on exploratory activity and memory in rats were compared. JMV-320 and CCK-4 did not modulate exploratory activity in an open field test but decreased it in an elevated plus-maze. CCK-4 (50 micrograms/kg) impaired passive avoidance re...

journal_title：Peptides

authors： Hadjiivanova C,Kehayov R,Petkov VV,Amblard M,Martinez J

更新日期：1995-01-01 00:00:00

abstract：:Vascular permeability and endothelial cell damage has been shown to occur in rats subjected to trauma with hemorrhagic-shock. Although the factors responsible for the endothelial cell injury are unknown, it has been hypothesized that toxic factors produced in response to hemorrhagic-shock originate in the gut and are ...

journal_title：Peptides

authors： Kaiser VL,Sifri ZC,Senthil M,Dikdan GS,Lu Q,Xu DZ,Deitch EA

更新日期：2005-12-01 00:00:00

abstract：:Although a great deal is published on the MCH neurons, very few works were devoted to the study of their development. However, existing literature points out two important traits: first, these neurons differentiate a MCH phenotype very early in all species studied so far, which might suggest a role for the MCH peptide...

journal_title：Peptides

authors： Risold PY,Croizier S,Legagneux K,Brischoux F,Fellmann D,Griffond B

更新日期：2009-11-01 00:00:00

abstract：:C-type natriuretic peptide (CNP) is assuming increasing importance in cardiovascular disease, and in adults its plasma levels are related to clinical and functional disease severity. Data are scarce regarding the reference values for CNP in infancy. Aim of this study was to assess the reference intervals for CNP in hu...

journal_title：Peptides

authors： Del Ry S,Cantinotti M,Cabiati M,Caselli C,Storti S,Prescimone T,Murzi B,Clerico A,Giannessi D

更新日期：2012-01-01 00:00:00

abstract：:Recent studies have provided evidence for the dense localization of atrial natriuretic factor (ANF) in the anteroventral third ventricle (AV3V) region of the rat brain. This area is currently thought to be involved in the regulation of blood pressure and fluid and electrolyte balance. To investigate whether ANF may pl...

journal_title：Peptides

authors： Sills MA,Nguyen KQ,Jacobowitz DM

更新日期：1985-11-01 00:00:00

abstract：:Previous reports have demonstrated that systemic injection of cholecystokinin (CCK) in rats produces dose-related decreases in food intake, increases in neurohypophyseal secretion of oxytocin (OT), and decreases in gastric emptying. The present studies determined whether systemic injection of bombesin (BBS), another p...

journal_title：Peptides

authors： Verbalis JG,McCann MJ,Stricker EM

更新日期：1988-11-01 00:00:00

abstract：:Galanin has been shown to be present in substantial quantities in the human and rat genitourinary tract by radioimmunoassay and immunocytochemistry. The highest concentrations measured by radioimmunoassay were found in the human vas deferens, corpus cavernosum and spongiosum and in the vagina and cervix. In man gel ch...

journal_title：Peptides

authors： Bauer FE,Christofides ND,Hacker GW,Blank MA,Polak JM,Bloom SR

更新日期：1986-01-01 00:00:00

abstract：:The antibacterial activity of peptides without disulfide bridges, spanning the carboxy-terminal segment of arthropod defensins, has been investigated. Although all the peptides have net positive charges, they exhibited varying antibacterial potencies and spectra. Atomic force and fluorescence microscopic analyses indi...

journal_title：Peptides

authors： Varkey J,Singh S,Nagaraj R

更新日期：2006-11-01 00:00:00

abstract：:Members of the neprilysin family of neutral endopeptidases (M13) are typically membrane-bound enzymes known to be involved in the extra-cellular metabolism of signalling peptides and have important roles during mammalian embryogenesis. In this study we show that membranes prepared from embryos of Drosophila melanogast...

journal_title：Peptides

authors： Bland ND,Thomas JE,Audsley N,Shirras AD,Turner AJ,Isaac RE

更新日期：2007-01-01 00:00:00

abstract：:Ghrelin, a novel gut hormone, has been shown to exert protective effects on cardiac dysfunction and remodeling. However, the underlying mechanisms of its protective effects remain unclear. Here, we investigated the effects of ghrelin on cardiac hypertrophy and explored the mechanisms involved. Ghrelin (30 μg.kg-1. day...

journal_title：Peptides

authors： Lu W,Cai H,Chen Y,Liao X,Zhang L,Ma T,Sun H,Qi Y

更新日期：2020-11-13 00:00:00

abstract：:The purpose of this investigation was to determine the influence of long-distance running on the secretion of the gastrointestinal peptide hormones cholecystokinin (CCK) and gastrin. Several known stress hormones, ACTH, cortisol and norepinephrine, were also measured. The hormones were estimated before and after a com...

journal_title：Peptides

authors： Philipp E,Wilckens T,Friess E,Platte P,Pirke KM

更新日期：1992-01-01 00:00:00

abstract：:Acute and chronic effects of gamma-butyrolactone-gamma-carbonyl-histidyl-prolinamide (DN-1417) were investigated on motor activity, dopamine (DA) metabolites and DA receptors in various brain regions of rats. The motor activity, as measured with Automex recorder, was enhanced after a single injection with DN-1417 (20 ...

journal_title：Peptides

authors： Nakahara T,Matsumoto T,Hirano M,Uchimura H,Yokoo H,Nakamura K,Ishibashi K,Hirano H

更新日期：1985-11-01 00:00:00

abstract：:Pharmacological experiments suggest that satiation associated with intestinal infusion of several nutrients is mediated by CCK-A receptors. Otsuka Long-Evans Tokushima Fatty, (OLETF), rats do not express CCK-A receptors and are insensitive to the satiation-producing effects of exogenous CCK. To further evaluate the ro...

journal_title：Peptides

authors： Covasa M,Ritter RC

更新日期：2001-08-01 00:00:00

abstract：:We have attempted to demonstrate a pancreatic secretory response to intraduodenal amino acids in the anesthetized cat. In four cats stimulated with supramaximal doses of secretin, protein concentrations in pancreatic juice were measured after intraduodenal bolus injection of various amino acids, IV CCK, or electrical ...

journal_title：Peptides

authors： Johnson C,Jeanningros R,Sarles H

更新日期：1982-03-01 00:00:00

abstract：:We compared the effects of three micro-(DAMGO, DALDA, TNPO) and three delta-(DPDPE, DELT, SNC-80) opioid agonists on arterial blood gas after IV administration in awake sheep. None of the mu agonists altered pO2, pCO2 or pH. All three mu agonists decreased pO2 increased pCO2 and decreased pO2, and this effect was not ...

journal_title：Peptides

authors： Szeto HH,Soong Y,Wu D,Olariu N,Kett A,Kim H,Clapp JF

更新日期：1999-01-01 00:00:00

abstract：:The biosynthetic activity of rat intermediate lobe melanotropes in vivo is inhibited by stimulation of dopamine D2 receptors. Individual melanotropes are innervated differentially by dopaminergic axons and vary in their levels of pro-opiomelanocortin (POMC) mRNA. We tested the hypothesis that placement of the lobe in ...

journal_title：Peptides

authors： Beatty DM,Morris SJ,Chronwall BM

更新日期：1998-01-01 00:00:00

abstract：:Dermorphins are potent opiate-like peptides isolated from the skin of some species of frogs. They are characterized by the presence of a D-amino acid residue, which is crucial for bioactivity. A number of analogues were prepared in order to evaluate the structure-activity relationships. The syntheses were accomplished...

journal_title：Peptides

authors： de Castiglione R,Faoro F,Perseo G,Piani S,Santangelo F,Melchiorri P,Falconieri Erspamer G,Erspamer V,Guglietta A

更新日期：1981-10-01 00:00:00

abstract：:The influence of central vs. peripheral administration of specific type A and type B CCK receptor antagonists (L364,718 and L365,260, respectively) on colonic motor hyperactivity induced by feeding and CCK8 was investigated in dogs with strain-gauge transducers implanted on the proximal and transverse colon. Intraveno...

journal_title：Peptides

authors： Gue M,Bueno L

更新日期：1991-05-01 00:00:00

abstract：:Neural membrane fractions, prepared from brain-subesophageal ganglion complexes of the adult lepidopteran Lymantria dispar, contain at least two peptidases capable of metabolizing locust adipokinetic hormone-I in vitro. The initial fragments, pGlu1-Leu2-Asn3 and Phe4-Thr5-Pro6-Asn7-Trp8-Gly9-Thr10, result from the act...

journal_title：Peptides

authors： Masler EP,Wagner RM,Kovaleva ES

更新日期：1996-01-01 00:00:00

abstract：:The Y5 receptor has been postulated to be the main receptor mediating NPY-induced food intake in rats, based on its pharmacological profile and mRNA distribution. To further characterize this important receptor subtype, we isolated the Y5 gene in the guinea pig, a widely used laboratory animal in which all other known...

journal_title：Peptides

authors： Lundell I,Eriksson H,Marklund U,Larhammar D

更新日期：2001-03-01 00:00:00

abstract：:Vasoactive intestinal peptide (VIP) enhances angiogenesis in rats with focal cerebral ischemia. In the present study, we investigated the molecular mechanism of the proangiogenic action of VIP using an in vitro ischemic model, in which rat brain microvascular endothelial cells (RBMECs) are subjected to oxygen and gluc...

journal_title：Peptides

authors： Yang J,Shi QD,Song TB,Feng GF,Zang WJ,Zong CH,Chang L

更新日期：2013-04-01 00:00:00

abstract：:Huwentoxin-I (HWTX-I) is a 33-residue peptide isolated from the venom of Ornithoctonus huwena and could inhibit TTX-sensitive voltage-gated sodium channels and N-type calcium channels in mammalian dorsal root ganglion (DRG) neurons. However, the effects of HWTX-I on mammalian central neuronal and insect sodium channel...

journal_title：Peptides

authors： Wang M,Rong M,Xiao Y,Liang S

更新日期：2012-03-01 00:00:00

abstract：:The presence of a putative GRP receptor on rat pancreatic particulate membranes was demonstrated by covalent cross-linking to 125I-gastrin releasing peptide (GRP), which revealed a radioactive band with Mr = 80-90 kDa on reduced SDS-PAGE. Fresh rat pancreatic membranes contained a GRP receptor which was solubilized wi...

journal_title：Peptides

authors： Kane MA,Kelley K,Ross SE,Portanova LB

更新日期：1991-03-01 00:00:00

abstract：:Two molecular forms of gonadotropin-releasing hormone (GnRH) were identified in the extracts of various brain areas, spinal cord and pituitary in female and male goldfish and had chromatographic and immunological properties similar to [His5, Trp7, Tyr8]-GnRH (cGnRH-II) and [Trp7,Leu8]-GnRH (sGnRH). Radioimmunoassay us...

journal_title：Peptides

authors： Yu KL,Sherwood NM,Peter RE

更新日期：1988-05-01 00:00:00

abstract：:In this study, we present evidence showing that endothelin (ET) potentiates the responses to adenosine, to 5'-N-ethylcarboxamidoad, a nonhydrolyzable adenosine agonist, and to isoprenaline. These responses seem to occur through ET-B receptors, as all three endothelin isopeptides have the same potency, sarafotoxin 6c h...

journal_title：Peptides

authors： Hernández F,Catalán RE,Martinez AM

更新日期：1999-01-01 00:00:00

abstract：:A newly developed system of isolated rat colonic epithelial cells was utilized for a comprehensive study of protein synthesis influenced by gastrin. We found that synthetic human gastrin (0.01-100 nM) increased the incorporation of [35S]methionine into proteins within 2 hours. Peak incorporation was observed with 10 n...

journal_title：Peptides

authors： Yassin RR,Clearfield HR,Katz SM,Murthy SN

更新日期：1991-01-01 00:00:00