Heterogeneity in POMC expression among explanted melanotropes decreases with time in culture and bromocriptine treatment.

abstract：:The effects of arginine vasotocin (AVT), 4-6 ng/kg, on renal function and plasma prolactin (PRL) were determined in conscious American foxhounds undergoing a water diuresis. Intravenous AVT produced an antidiuresis, kaliuresis and inconsistent natriuresis, independently of changes in GFR, blood pressure, heart rate an...

journal_title：Peptides

authors： Gilmore JP,Wesley CR,Huffman L,Nemeh MN

更新日期：1982-11-01 00:00:00

abstract：:Bradykinin (BK) has been proposed as the principal mediator of hypersensitivity reactions (HSR) in patients dialyzed using negatively charged membranes and concomitantly treated with angiotensin-converting enzyme (ACE) inhibitors. We investigated the metabolism of exogenous BK added to the sera of 13 patients dialyzed...

journal_title：Peptides

authors： Blais C Jr,Marc-Aurèle J,Simmons WH,Loute G,Thibault P,Skidgel RA,Adam A

更新日期：1999-01-01 00:00:00

abstract：:The renin-angiotensin system (RAS) is now recognized as an important modulator of body metabolic processes. The discovery of angiotensin-converting enzyme 2 (ACE2) has renewed interest in the potential therapeutic role of RAS modulation. Recent studies have pointed out the importance of the local balance between ACE/A...

journal_title：Peptides

authors： Moreira de Macêdo S,Guimarães TA,Feltenberger JD,Sousa Santos SH

更新日期：2014-12-01 00:00:00

abstract：:A novel 6.6 kDa antifungal peptide (NFAP) from the culture supernatant of the mold, Neosartorya fischeri (anamorf: Aspergillus fischerianus), and its encoding gene were isolated in this study. NFAP is a small, basic and cysteine-rich protein consisting of 57 amino acid residues. It shows 37.9-50% homology to similar p...

journal_title：Peptides

authors： Kovács L,Virágh M,Takó M,Papp T,Vágvölgyi C,Galgóczy L

更新日期：2011-08-01 00:00:00

abstract：:The effects of amiloride on ANF binding and ANF stimulation of cGMP were evaluated in rat glomeruli. Amiloride increased ANF binding to whole glomeruli and to glomerular membrane preparations. In contrast, amiloride enhanced ANF-stimulated cGMP accumulation only at 37 degrees C in whole glomeruli, but not at 4 degrees...

journal_title：Peptides

authors： Iwata T,Hardee E,Frohlich ED,Cole FE

更新日期：1989-05-01 00:00:00

abstract：:Activation of natriuretic peptide receptor-A (NPRA) produces the second messenger cGMP, which plays a pivotal role in maintaining blood pressure and cardiovascular homeostasis. In the present study, we have examined the role of trans-acting factor Ets-1 in transcriptional regulation of Npr1 gene (coding for NPRA). Usi...

journal_title：Peptides

authors： Kumar P,Arise KK,Pandey KN

更新日期：2006-07-01 00:00:00

abstract：:The location of the cells giving rise to the tachykinergic innervation of the rat arcuate nucleus was studied by combining immunohistochemistry and retrograde axonal transport of a protein-gold complex (WGA-ApoHRP-gold). Small volumes (20 nl) of this marker were injected into the arcuate nucleus of the rat. Twenty-fou...

journal_title：Peptides

authors： Magoul R,Onteniente B,Benjelloun W,Tramu G

更新日期：1993-03-01 00:00:00

abstract：:The peptide IIAEK derived from beta-lactoglobulin has a hypocholesterolemic activity greater than that of beta-sitosterol. To create food proteins with multiple copies of this valuable peptide sequence, we introduced tandem multimers of the nucleotide sequence encoding the peptide into DNA regions corresponding to the...

journal_title：Peptides

authors： Prak K,Maruyama Y,Maruyama N,Utsumi S

更新日期：2006-06-01 00:00:00

abstract：:The Manduca allatotropin (Mas-AT) gene is expressed as at least three mRNA isoforms that differ from each other by alternative splicing. The location at which the alternative exons are included in the mature mRNAs occur within the open reading frame, so that three different propeptides are predicted as translation pro...

journal_title：Peptides

authors： Horodyski FM,Bhatt SR,Lee KY

更新日期：2001-02-01 00:00:00

abstract：:The peptidome of the central nervous system of adult cabbage root fly, Delia radicum (L) was investigated using matrix assisted laser desorption ionization time of flight mass spectrometry (MALDI-TOF MS). Over twenty neuropeptides were identified from three different tissue sources, the combined brain/suboesophageal g...

journal_title：Peptides

authors： Audsley N,Matthews HJ,Down RE,Weaver RJ

更新日期：2011-03-01 00:00:00

abstract：:Natriuretic peptide receptor C (NPR-C) is known to bind all natriuretic peptides with similar affinity. Given their biological role it is interesting that natriuretic peptides and their activated guanylate cyclases (NPR-A and NPR-B) are expressed in retinal amacrine cells. The purpose of this study is to examine the p...

journal_title：Peptides

authors： Abdelalim EM,Tooyama I

更新日期：2010-01-01 00:00:00

abstract：:This report summarizes recent work on the chemistry and structure-activity relationships of crustacean chromatophorotropic pigment-dispersing hormones (PDHs) and the identification of structurally related peptides from insects. So far, the primary structures of crustacean alpha-PDH and beta-PDH and of a pigment-disper...

journal_title：Peptides

authors： Rao KR,Riehm JP

更新日期：1988-01-01 00:00:00

abstract：:Gastrin-releasing peptide (GRP) has been implicated in the itch-scratch cycle. We investigated if this gut-brain-skin peptide plays a role in the compulsive, hindleg scratching of the neck of mice by 5'-guanidinonaltrindole (GNTI), the kappa opioid receptor antagonist, and in the antipruritic activity of nalfurafine, ...

journal_title：Peptides

authors： Inan S,Dun NJ,Cowan A

更新日期：2011-02-01 00:00:00

abstract：:In these studies the pattern of feeding behavior during continuous intraventricular (IVT) infusion of NPY for 4 hr in the satiated female rat was monitored. Whereas saline infusion was ineffective, each of the three doses of NPY (117, 470 or 1175 pmol/hr) increased feeding during the entire 4 hr infusion and 2 hr post...

journal_title：Peptides

authors： Kalra SP,Dube MG,Kalra PS

更新日期：1988-07-01 00:00:00

abstract：:New dual immunocytochemical staining procedures were used in the same tissue section to elucidate the distribution and co-existence of CRF and vasopressin in parvocellular neuronal perikarya in the paraventricular nucleus (PVN) of rat hypothalamus. CRF immunostained cells were for the most part concentrated in the med...

journal_title：Peptides

authors： Piekut DT,Joseph SA

更新日期：1986-09-01 00:00:00

abstract：:The hypocretins (1 and 2) have emerged as key regulators of sleep and wakefulness. We developed a high-throughput enzyme immunoassay (EIA) to measure total brain hypocretin levels from large numbers of mice. Hypocretin levels were not altered by circadian time or age. However, significant differences in one or both hy...

journal_title：Peptides

authors： Lin L,Wisor J,Shiba T,Taheri S,Yanai K,Wurts S,Lin X,Vitaterna M,Takahashi J,Lovenberg TW,Koehl M,Uhl G,Nishino S,Mignot E

更新日期：2002-12-01 00:00:00

abstract：:In an attempt to establish the role of F8Famide in opioid activity modulation, we examined the effects of intracerebroventricular administration of the F8Famide analogs (1DME)Y8Fa and (3D)Y8Fa on intestinal transit in mice. (1DME)Y8Fa (0.88 to 22 nmol) inhibited intestinal transit as did F8Famide and morphine. An IP i...

journal_title：Peptides

authors： Gicquel S,Fioramonti J,Bueno L,Zajac JM

更新日期：1993-07-01 00:00:00

abstract：:A peptide designated cicerarin, with an N-terminal amino acid sequence VKSTGRADDDLAVKTKYLPP dissimilar from known proteins and peptides and a molecular mass of 8kDa, was isolated from seeds of the green chickpea Cicer arietinum cv green chickpea. Cicerarin was isolated with a procedure that involved ion exchange chrom...

journal_title：Peptides

authors： Chu KT,Liu KH,Ng TB

更新日期：2003-05-01 00:00:00

abstract：:Brazilian freshwater stingrays, Potamotrygon gr. orbigyni, are relatively common in the middle-western regions of Brazil, where they are considered an important public health threat. In order to identify some of their naturally occurring toxin peptides available in very low amounts, we combine analytical protocols suc...

journal_title：Peptides

authors： Conceição K,Santos JM,Bruni FM,Klitzke CF,Marques EE,Borges MH,Melo RL,Fernandez JH,Lopes-Ferreira M

更新日期：2009-12-01 00:00:00

abstract：:Higher levels of natriuretic peptides were identified in outpatients after myocardial infarction (MI) compared to the healthy population, even in the absence of heart failure (HF). Therefore, we assessed the optimal cut-off value of B-type natriuretic peptide (BNP) in relation to new-onset HF prediction in 79 post-MI ...

journal_title：Peptides

authors： Radovanovic M,Vasiljevic Z,Radovanovic N,Marinkovic J,Beleslin B,Mitrovic P,Stankovic S,Stankovic G

更新日期：2010-10-01 00:00:00

abstract：:Increased plasma levels of neuropeptide Y (NPY)-like immunoreactivity (p-NPY-LI) have been described in hemodialysis (HD) patients. In this investigation the effect of a standard HD on p-NPY-LI, analyzed by radioimmunoassay and reverse-phase high performance liquid chromatography (HPLC), was studied. During dialysis p...

journal_title：Peptides

authors： Hegbrant J,Thysell H,Ekman R

更新日期：1995-01-01 00:00:00

abstract：:Acute and chronic effects of gamma-butyrolactone-gamma-carbonyl-histidyl-prolinamide (DN-1417) were investigated on motor activity, dopamine (DA) metabolites and DA receptors in various brain regions of rats. The motor activity, as measured with Automex recorder, was enhanced after a single injection with DN-1417 (20 ...

journal_title：Peptides

authors： Nakahara T,Matsumoto T,Hirano M,Uchimura H,Yokoo H,Nakamura K,Ishibashi K,Hirano H

更新日期：1985-11-01 00:00:00

abstract：:In this work, we characterized the active site in the alpha-melanotropin hormone (alpha-MSH) sequence responsible for the enhancement of cAMP production in incubated striatal slices by using different alpha-MSH fragments. We also analyzed the effects of the co-incubation of the SCH23390, a dopaminergic D(1) antagonist...

journal_title：Peptides

authors： Cecilia Cremer M,Silvina Sanchez M,Ester Celis M

更新日期：2000-06-01 00:00:00

abstract：:A newly developed system of isolated rat colonic epithelial cells was utilized for a comprehensive study of protein synthesis influenced by gastrin. We found that synthetic human gastrin (0.01-100 nM) increased the incorporation of [35S]methionine into proteins within 2 hours. Peak incorporation was observed with 10 n...

journal_title：Peptides

authors： Yassin RR,Clearfield HR,Katz SM,Murthy SN

更新日期：1991-01-01 00:00:00

abstract：:Several cardioactive peptides from the pulmonate snail Helix aspersa were tested for their effects on myocardial cAMP levels, but only the family of small cardioactive peptides (SCPs) were clearly effective. SCP increased cAMP in a dose dependent manner; the time course was phasic. The structure-activity relations of ...

journal_title：Peptides

authors： Reich G,Doble KE,Price DA,Greenberg MJ

更新日期：1997-01-01 00:00:00

abstract：:The effects of infusion of low concentrations of the synthetic opioid peptide D-Pro4-beta-casomorphin-5(deprolorphin) on electrical field responses in the in vitro hippocampal slice preparation of mice were investigated. Deprolorphin (0.01-10 microM) causes a large enhancement of the population spike (PS) and appearan...

journal_title：Peptides

authors： Reymann KG,Chepkova AN,Matthies H

更新日期：1983-05-01 00:00:00

abstract：:The relationship between gallbladder (GB) bile concentration and motility was studied in conscious dogs. The 12-h GB bile concentrations between meals could be divided into three periods: diluting, minimum, and concentrating periods. During the diluting period, inhibition of GB contractions by a CCKA receptor antagoni...

journal_title：Peptides

authors： Muramatsu S,Sonobe K,Mizumoto A,Yamada T,Itoh Z

更新日期：1997-01-01 00:00:00

abstract：:Pharmacological study of Phe-Met-Leu-Phe-amide (FMRFa) receptors is hindered by the lack of selective ligands. The classification of these selective ligands is further hampered by the limited availability of functional assays. In this study, we evaluated several synthetic FMRFa analogs for agonist and antagonist activ...

journal_title：Peptides

authors： Heyliger SO,Payza K,Rothman RB

更新日期：1998-01-01 00:00:00

abstract：:The objective of this study was to explore the effects of the endogenous opioid peptide dynorphin A(1-13) on the CNS regulation of blood pressure and heart rate. Wistar rats, anesthetized with pentobarbital and halothane, received dynorphin A(1-13) microinjected into the anterior hypothalamus area (AHA), the posterior...

journal_title：Peptides

authors： Rabkin SW

更新日期：1993-11-01 00:00:00

abstract：:We have evaluated a new immunoradiometric assay (IRMA) for calcitonin (CT) (Medgenix, Belgium). The detection limit of immunoreactive CT (IR-CT) was 2.8 pg/ml, and plasma levels of IR-CT of 134 healthy adults (dynamic range, 2.8-1000 pg/ml) were < 19 pg/ml (median 4.1 pg/ml). Both basal and pentagastrin-stimulated IR-...

journal_title：Peptides

authors： Wimalawansa SJ,Bailey F

更新日期：1995-01-01 00:00:00