Abstract:
:The hypocretins (1 and 2) have emerged as key regulators of sleep and wakefulness. We developed a high-throughput enzyme immunoassay (EIA) to measure total brain hypocretin levels from large numbers of mice. Hypocretin levels were not altered by circadian time or age. However, significant differences in one or both hypocretin peptides were observed between different mouse strains. We studied hypocretin levels in knockout and transgenic mouse models with obesity, circadian gene mutations or monoaminergic defects. Compared to controls, only histamine receptor knockouts had lower hypocretin levels. This was most pronounced in H1 receptor knockouts suggesting the existence of a positive feedback loop between hypocretin and histaminergic neurons.
journal_name
Peptidesjournal_title
Peptidesauthors
Lin L,Wisor J,Shiba T,Taheri S,Yanai K,Wurts S,Lin X,Vitaterna M,Takahashi J,Lovenberg TW,Koehl M,Uhl G,Nishino S,Mignot Edoi
10.1016/s0196-9781(02)00251-6subject
Has Abstractpub_date
2002-12-01 00:00:00pages
2203-11issue
12eissn
0196-9781issn
1873-5169pii
S0196978102002516journal_volume
23pub_type
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