Abstract:
:As a novel vasoactive peptide, plasma coupling factor 6 (CF6) was shown to be elevated in patients with diabetes mellitus, yet the mechanism involved is unknown. We studied CF6 protein release and its potential mechanism in human umbilical vein endothelial cells (HUVECs) incubated with high glucose levels. High glucose level enhanced CF6 expression and peptide secretion in HUVECs in a time- and concentration-dependent manner, which was independent of increased osmolarity. PKC or p38 MAPK inhibition significantly suppressed high glucose-mediated CF6 release in HUVECs, and the inhibition rate was -45% and -30%, respectively. Also, high glucose-induced CF6 production was antagonized by insulin treatment. Hence, high glucose increases the expression and secretion of CF6 in endothelial cells and appears to be mediated by PKC and p38 MAPK activity.
journal_name
Peptidesjournal_title
Peptidesauthors
Li X,Xing S,Zhang L,Xing Q,Yan S,Dai H,You S,Pang Y,Tang Cdoi
10.1016/j.peptides.2006.11.006subject
Has Abstractpub_date
2007-03-01 00:00:00pages
683-90issue
3eissn
0196-9781issn
1873-5169pii
S0196-9781(06)00514-6journal_volume
28pub_type
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