Abstract:
:The effect of intraplantarly (i.pl.)-injected methionine-enkephalin (ME) on Concanavalin A (Con A)-induced paw edema in Dark Agouti (DA) and Albino Oxford (AO) rats was investigated. ME suppressed edema in DA rats, which was antagonized with naloxone (non-selective opioid receptor antagonist) and naltrindole (delta opioid receptors antagonist). Potentiating effect of ME in AO rats was blocked by naloxone, nor-binaltorphimine (kappa opioid receptors antagonist) and beta-funaltrexamine (mu opioid receptors antagonist). Dexamethasone suppressed edema in both rat strains. These findings suggest that strain-dependent differences in the effects of ME on inflammation in DA and AO rats could be related to diversity in opioid receptors expression in these strains.
journal_name
Peptidesjournal_title
Peptidesauthors
Stanojević S,Radulović J,Kovacević-Jovanović V,Vujić V,Dimitrijević Mdoi
10.1016/s0196-9781(02)00105-5subject
Has Abstractpub_date
2002-09-01 00:00:00pages
1597-605issue
9eissn
0196-9781issn
1873-5169pii
S0196978102001055journal_volume
23pub_type
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