Central and peripheral components of dermorphin's effect on rat intestinal propulsion in comparison to morphine.

abstract：:The influence of central vs. peripheral administration of specific type A and type B CCK receptor antagonists (L364,718 and L365,260, respectively) on colonic motor hyperactivity induced by feeding and CCK8 was investigated in dogs with strain-gauge transducers implanted on the proximal and transverse colon. Intraveno...

journal_title：Peptides

authors： Gue M,Bueno L

更新日期：1991-05-01 00:00:00

abstract：:The goal of our study was to explore the effect of social isolation stress of varying durations on the plasma oxytocin (OT), messenger ribonucleic acid (mRNA) for oxytocin receptor (OTR), plasma arginine vasopressin (AVP) and mRNA for V1a receptor of AVP (V1aR) expression in the hypothalamus and heart of socially mono...

journal_title：Peptides

authors： Pournajafi-Nazarloo H,Kenkel W,Mohsenpour SR,Sanzenbacher L,Saadat H,Partoo L,Yee J,Azizi F,Carter CS

更新日期：2013-05-01 00:00:00

abstract：:The corpora cardiaca (CC) of two water bug species, the water boatman Corixa punctata and the saucer bug Ilyocoris cimicoides, contain a substance that cause hyperlipemia in the migratory locust. The primary sequence of one octapeptide belonging to the adipokinetic hormone (AKH)/red pigment-concentrating hormone (RPCH...

journal_title：Peptides

authors： Gäde G,Simek P,Marco HG

更新日期：2007-03-01 00:00:00

abstract：:Increasing evidence suggests a role for ghrelin in the control of articular inflammatory diseases like osteoarthritis (OA). In the present study we examined the ability of ghrelin to counteract LPS-induced necrosis and apoptosis of chondrocytes and the involvement of GH secretagogue receptor (GHS-R)1a in the protectiv...

journal_title：Peptides

authors： Ceriotti S,Consiglio AL,Casati L,Cremonesi F,Sibilia V,Ferrucci F

更新日期：2018-05-01 00:00:00

abstract：:Radioautographic determinations of 125I-[Tyr0,D-Trp8]somatostatin-14 (125I-SRIF) binding sites were performed on frozen serial sections of the locus coeruleus (LC) of control rats and of rats subjected to either bilateral microinjections of 6 hydroxydopamine (6-OHDA) into the LC or unilateral microinjection into the a...

journal_title：Peptides

authors： Epelbaum J,Bluet-Pajot MT,Llorens-Cortes C,Kordon C,Mounier F,Senut MC,Videau C

更新日期：1990-01-01 00:00:00

abstract：:The binding activity of several galanin fragments and analogs was measured on specific receptors present in rat brain and the rat pancreatic beta cell line Rin m 5F. In both tissues it was observed that: 1) galanin(3-29), galanin(10-29) and [Ile2]-galanin were ineffective for inhibiting [125I] galanin binding and 2) a...

journal_title：Peptides

authors： Lagny-Pourmir I,Lorinet AM,Yanaihara N,Laburthe M

更新日期：1989-07-01 00:00:00

abstract：:Peptides influence cardiac dysfunction; however, peptidergic modulation of contractile performance remains relatively uncharacterized. We identified a novel human peptide that modulates mammalian contractile performance. Members of the FMRFamide-related peptide (FaRP) family contain a C-terminal RFamide but structural...

journal_title：Peptides

authors： Nichols R,Demers LA,Larsen BM,Robinson D,Converso K,Russell MW,Westfall MV

更新日期：2010-11-01 00:00:00

abstract：:The central effect of cholecystokinin-octapeptide (CCK), SQ 19,844 or sincalide, on the intake of food and water and on colonic temperature (Tc) was investigated using the broiler cockerel. Four-week old chicks were maintained in a thermoneutral environment of 23-24 degrees C. After food was removed for a 24 hr interv...

journal_title：Peptides

authors： Denbow DM,Myers RD

更新日期：1982-09-01 00:00:00

abstract：:During a systemic search for peptides that possess the C-terminal amide structure, a novel heptapeptide with isoleucine amide was isolated from bovine serum by sequential steps of reversed phase HPLC. Microsequence and amino acid analyses revealed the structure: Asp-Thr-His-Lys-Ser-Glu-Ile-NH2. Since this peptide has ...

journal_title：Peptides

authors： Takamatsu K,Tatemoto K

更新日期：1991-03-01 00:00:00

abstract：:Using a one-bottle taste aversion conditioning paradigm, sulfated cholecystokinin(26-33) (CCK-8) has again been shown to induce taste aversion conditioning in rats. Even though the effective doses of CCK-8 are relatively high, they do not induce as strong an aversion as has been demonstrated with LiCl. This pharmacody...

journal_title：Peptides

authors： Ervin GN,Mosher JT,Birkemo LS,Johnson MF

更新日期：1995-01-01 00:00:00

abstract：:MPF is a tetrapeptide (structure Lys-Lys-Gly-Glu) that elicits a variety of neurotrophic effects in vivo consistent with a role in neuronal regeneration. In support of this role, we now show that MPF stimulates the proliferation of cultured astrocytes and neurite outgrowth from cultures of neocortical cholinergic and ...

journal_title：Peptides

authors： Owen DB,Morley JS,Ensor DM,Allen YS,Miles JB

更新日期：1997-01-01 00:00:00

abstract：:We recently reported the direct inhibitory effect of adrenomedullin on caecal circular smooth muscle cells via cAMP system. This study was designed to determine whether the structurally related peptides to adrenomedullin (i.e.; calcitonin gene-related peptide (CGRP), calcitonin, and amylin) can inhibit the cholecystok...

journal_title：Peptides

authors： Ochiai T,Chijiiwa Y,Motomura Y,Yasuda O,Harada N,Nawata H

更新日期：2001-06-01 00:00:00

abstract：:Short cell penetrating peptides (CPP) are widely used in vitro to transduce agents into cells. But their systemic effect has not been yet studied in detail. We studied the systemic effect of the cell penetrating peptides, penetratin, transportan and pro-rich, on rat hemodynamic functions. Intra-arterial monitoring of ...

journal_title：Peptides

authors： Basheer M,Schwalb H,Shefler I,Levdansky L,Mekori YA,Gorodetsky R

更新日期：2011-12-01 00:00:00

abstract：:Because plasma levels of protein C (PC) or activated protein C (APC) are altered in certain diseases associated with vascular dysfunction, and APC has therapeutic potential in preventing microvascular coagulation in severe sepsis, potential vascular effects of PC and APC were compared to those of the vasoactive peptid...

journal_title：Peptides

authors： Bhattacharya A,Grinnell BW,Cohen ML

更新日期：2000-08-01 00:00:00

abstract：:Native peptides can be regarded as surrogate markers for protease activity in biological samples. Analysis of peptides by peptidomics allows to monitor protease activity in vivo and to describe the influence of protease inhibition. To elucidate the potential of peptides as markers for in vivo protease inhibition we an...

journal_title：Peptides

authors： Tammen H,Hess R,Rose H,Wienen W,Jost M

更新日期：2008-12-01 00:00:00

abstract：:Angiotensin (Ang)--a peptide that is part of the renin-angiotensin system-induces vasoconstriction and a subsequent increase in blood pressure; Ang peptides, especially AngII, can also act as potent pro-inflammatory mediators. Platelet-activating factor (PAF) is a potent phospholipid mediator that is implicated in man...

journal_title：Peptides

authors： Sato A,Yokoyama I,Ebina K

更新日期：2015-11-01 00:00:00

abstract：:I.c.v. injection for 9 days of either naltexone (NTX) (5, 10, 20, 40 micrograms/rat) or a selective mu peptide (CTOP) (0.125, 0.25, 0.5, 1, 3, 6 micrograms/rat) or delta (naltrindole) (NLT) (5, 10, 20 micrograms/rat) subtype opioid receptor antagonist affected sensitization to cocaine (COC) (50 mg/kg, i.p.) administer...

journal_title：Peptides

authors： Braida D,Paladini E,Gori E,Sala M

更新日期：1997-01-01 00:00:00

abstract：:Pacifastin-like protease inhibitors belong to a recent classified protease inhibitor family and they are the smallest protease inhibitors described in animals. In this work, we purified and characterized, for the first time, two neutrophil elastase inhibitors belonging to the pacifastin family from the blood sucking i...

journal_title：Peptides

authors： de Marco R,Lovato DV,Torquato RJ,Clara RO,Buarque DS,Tanaka AS

更新日期：2010-07-01 00:00:00

abstract：:Dipeptidyl peptidase-4 (DPP-4) inhibitor and exercise have proven to be effective treatments for diabetes. However, the effects of these interventions in compensatory hyperinsulinemia prediabetic period are unknown. The purpose of this study was to determine if these interventions have protective effects on β-cell fun...

journal_title：Peptides

authors： Li Y,Xiao J,Tian H,Pei Y,Lu Y,Han X,Liu Y,Zhong W,Sun B,Fang F,Shu H

更新日期：2013-11-01 00:00:00

abstract：:Just as the blood-brain barrier (BBB) is not a static barrier, the adipocytes are not inert storage depots. Adipokines are peptides or polypeptides produced by white adipose tissue; they play important roles in normal physiology as well as in the metabolic syndrome. Adipokines secreted into the circulation can interac...

journal_title：Peptides

authors： Pan W,Kastin AJ

更新日期：2007-06-01 00:00:00

abstract：:To determine the functional role for and the pharmacological specificity of developing gastrointestinal CCK receptors, in vitro pyloric contractility and autoradiographic CCK receptor binding were examined in pups aged 1-20 days. CCK contracted the gastroduodenal junction at all ages, while nonsulfated CCK-8 (d-CCK) w...

journal_title：Peptides

authors： Schwartz GJ,Moran TH,McHugh PR

更新日期：1990-11-01 00:00:00

abstract：:In these studies the pattern of feeding behavior during continuous intraventricular (IVT) infusion of NPY for 4 hr in the satiated female rat was monitored. Whereas saline infusion was ineffective, each of the three doses of NPY (117, 470 or 1175 pmol/hr) increased feeding during the entire 4 hr infusion and 2 hr post...

journal_title：Peptides

authors： Kalra SP,Dube MG,Kalra PS

更新日期：1988-07-01 00:00:00

abstract：:Vasoactive intestinal peptide (VIP) is a neuropeptide present in high concentrations in the hippocampus. The studies reported here demonstrate that VIP administered into the third ventricle of the brain caused amnesia in mice trained on a left-right footshock avoidance task in a T-maze. VIP resulted in amnesia when ad...

journal_title：Peptides

authors： Flood JF,Garland JS,Morley JE

更新日期：1990-09-01 00:00:00

abstract：:Quantitative receptor autoradiography was used to examine the binding of [125I]-human CGRP in the dorsal horn of the L4 spinal segment of rats with a chronic constriction injury (CCI) of the sciatic nerve or unilateral dorsal rhizotomies of spinal segments L1-L6. At the times selected for study, we found no change in ...

journal_title：Peptides

authors： Garry MG,Kajander KC,Bennett GJ,Seybold VS

更新日期：1991-11-01 00:00:00

abstract：:Urocortin is a newly identified member of the CRF neuropeptide family. Urocortin has been found to bind with high affinity to CRF receptors. The present study investigated urocortin and CRF receptor expression in human colonic mucosa. Non-pathologic sections of adult colorectal tissues were obtained from patients with...

journal_title：Peptides

authors： Muramatsu Y,Fukushima K,Iino K,Totsune K,Takahashi K,Suzuki T,Hirasawa G,Takeyama J,Ito M,Nose M,Tashiro A,Hongo M,Oki Y,Nagura H,Sasano H

更新日期：2000-12-01 00:00:00

abstract：:We assessed the plasma acyl ghrelin (AG), unacyl ghrelin (UAG), and total ghrelin (TGhr) levels in Chinese adults with pre-diabetes and newly diagnosed diabetes mellitus (NDDM) after an oral glucose tolerance test (OGTT), and abdominal subcutaneous fat area and visceral fat area (VFA) were measured. Fasting AG level w...

journal_title：Peptides

authors： Huang L,Tong Y,Zhang F,Yang Q,Li D,Xie S,Li Y,Cao H,Tang L,Zhang X,Tong N

更新日期：2014-10-01 00:00:00

abstract：:We have developed a specific and sensitive radioimmunoassay for the hydra head activator neuropeptide (HHAP). The antibody recognizes the C-terminal portion of HHAP and shows no cross-reactivity with other neuropeptides. The assay allows measurement of HHAP-like material in tissue extracts with a minimum detectable co...

journal_title：Peptides

authors： Ekman R,Salford L,Brun A,Larsson I

更新日期：1990-03-01 00:00:00

abstract：:Angiotensin II (ANG II) receptors were present in the thymus of newborn rats (179 +/- 34 fmol/mg protein). In newborns, binding was predominantly localized in the trabecula, and was selectively displaced by the AT2 ligand CGP 42112A (83-85%) and to a lower extent by the AT1 antagonist losartan (15-17%), indicating a m...

journal_title：Peptides

authors： Corrêa FM,De Oliveira AM,Viswanathan M,Saavedra JM

更新日期：1994-01-01 00:00:00

abstract：:We have studied the in vitro effect of VIP and histamine on ultrastructure of the parietal cells in isolated guinea pig fundic glands. The morphological changes induced by histamine in the parietal cells can be compared to those observed after histamine stimulation in vivo or in vitro on gastric mucosa preparations. I...

journal_title：Peptides

authors： Anteunis A,Gespach C,Astesano A,Emami S,Robineaux R,Rosselin G

更新日期：1984-03-01 00:00:00

abstract：:We have developed a radioimmunoassay for synthetic dynorphin B, a novel opioid tridecapeptide, which shares a common precursor molecule with dynorphin1-17 (= dynorphin A) and the neo-endorphins. The levels of immunoreactivity towards this peptide in rat brain and pituitary show a pattern quantitatively and qualitative...

journal_title：Peptides

authors： Zhu YX,Höllt V,Loh H

更新日期：1983-11-01 00:00:00