Abstract：
:Angiotensin II (ANG II) receptors were present in the thymus of newborn rats (179 +/- 34 fmol/mg protein). In newborns, binding was predominantly localized in the trabecula, and was selectively displaced by the AT2 ligand CGP 42112A (83-85%) and to a lower extent by the AT1 antagonist losartan (15-17%), indicating a marked predominance of AT2 receptors. Angiotensin II binding was very low in the cortical and medullary areas in the thymus of newborn rats and was no longer detected in the thymus of 4- and 8-week-old rats. No detectable binding for the ACE inhibitor [125I]351A was observed in the thymus of the rat, regardless of the age studied. Our results indicate a possible role for circulating ANG II during development of the thymus with no clear correlation to lymphocyte maturation.
journal_name
Peptidesjournal_title
Peptidesauthors
Corrêa FM,De Oliveira AM,Viswanathan M,Saavedra JMdoi
10.1016/0196-9781(94)90036-1subject
Has Abstractpub_date
1994-01-01 00:00:00pages
821-4issue
5eissn
0196-9781issn
1873-5169pii
0196-9781(94)90036-1journal_volume
15pub_type
杂志文章相关文献
PEPTIDES文献大全abstract：:Due to recent emergence of fungal pathogens resistant to current antifungal therapies, several studies have been focused on screening of plant peptides to find novel compounds having antifungal activities. Here, a novel antifungal plant peptide, with molecular mass of 1230 Da was purified from fruits of Trapa natans b...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2011.06.020
更新日期：2011-08-01 00:00:00
abstract：:Sex pheromone biosynthesis in many moth species is controlled by a cerebral neuropeptide, termed pheromone biosynthesis activating neuropeptide (PBAN). PBAN is a 33 amino acid C-terminally amidated neuropeptide that is produced by neuroendocrine cells of the subesophageal ganglion (SEG). Studies of the regulation of s...
journal_title：Peptides
pub_type： 杂志文章,评审
doi：10.1016/j.peptides.2004.06.020
更新日期：2004-09-01 00:00:00
abstract：:Bacillus thuringiensis subsp. israelensis (Bti) produces at least four different crystal proteins that are specifically toxic to different mosquito species and that belong to two non-related family of toxins, Cry and Cyt named Cry4Aa, Cry4Ba, Cry11Aa and Cyt1Aa. Cyt1Aa enhances the activity of Cry4Aa, Cry4Ba or Cry11A...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2010.06.005
更新日期：2011-03-01 00:00:00
abstract：:Pharmacological experiments suggest that satiation associated with intestinal infusion of several nutrients is mediated by CCK-A receptors. Otsuka Long-Evans Tokushima Fatty, (OLETF), rats do not express CCK-A receptors and are insensitive to the satiation-producing effects of exogenous CCK. To further evaluate the ro...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/s0196-9781(01)00461-2
更新日期：2001-08-01 00:00:00
abstract：:The extractability of neurotensin (NT) from porcine ileal mucosa was studied by comparison of eight extraction procedures. Tissue content of neurotensin-like immunoreactivity was quantitated and characterized by sequence-specific radioimmunoassays and gel filtration chromatography. Homogenization prior to boiling in e...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(87)90038-6
更新日期：1987-07-01 00:00:00
abstract：:Enzymatic cleavage of endogenous peptides is a commonly used principle to initiate, modulate and terminate action for instance among cytokines and peptide hormones. The incretin hormones, glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1), and the related hormone glucagon-like pepti...
journal_title：Peptides
pub_type： 杂志文章,评审
doi：10.1016/j.peptides.2019.170224
更新日期：2020-03-01 00:00:00
abstract：:We have attempted to demonstrate a pancreatic secretory response to intraduodenal amino acids in the anesthetized cat. In four cats stimulated with supramaximal doses of secretin, protein concentrations in pancreatic juice were measured after intraduodenal bolus injection of various amino acids, IV CCK, or electrical ...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(82)90040-7
更新日期：1982-03-01 00:00:00
abstract：:The major amyloid-beta (Abeta) peptides found in the brain of familial and late onset Alzheimer's disease include the full-length Abeta1-42 and N-terminally truncated, pyroglutamylated peptides Abetap3-42 and Abetap11-42. The biophysical properties of Abeta1-42 have been extensively studied, yet little is known about ...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2009.01.027
更新日期：2009-05-01 00:00:00
abstract：:Urocortin (Ucn) 1, 2 and 3 are corticotropin-releasing factor (CRF)-related peptides recently characterized in mammals. Urocortin 1 binds with high affinity to CRF type 1 (CRF1) and type 2 (CRF2) receptors while Ucn 2 and Ucn 3 are selective CRF2 ligands. They also have a distinct pattern of distribution, both in the ...
journal_title：Peptides
pub_type： 杂志文章,评审
doi：10.1016/j.peptides.2004.05.025
更新日期：2004-10-01 00:00:00
abstract：:Obestatin is produced in the stomach from proghrelin by post-translational cleavage. The initial report claimed anorexigenic effects of obestatin in mice. Contrasting studies indicated no effect of obestatin on food intake (FI). We investigated influences of metabolic state (fed/fasted), environmental factors (dark/li...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2008.01.020
更新日期：2008-06-01 00:00:00
abstract：:C-type natriuretic peptide (CNP) significantly increases in chronic heart failure (CHF) patients as a function of clinical severity. Aim of this study was to evaluate in CHF patients the relationship between circulating CNP concentrations and echo-Doppler conventional indices of left ventricular (LV) function as well ...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2007.10.022
更新日期：2008-01-01 00:00:00
abstract：:Native peptides can be regarded as surrogate markers for protease activity in biological samples. Analysis of peptides by peptidomics allows to monitor protease activity in vivo and to describe the influence of protease inhibition. To elucidate the potential of peptides as markers for in vivo protease inhibition we an...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2008.08.016
更新日期：2008-12-01 00:00:00
abstract：:Inhibitors of metallopeptidases may represent new alternatives in the treatment of cardiovascular disease. Recent investigations have linked the hypotensive properties of the metalloendopeptidase 3.4.24.15 (MEP 24.15) inhibitor c-phenylpropyl-alanyl-alanyl-phenylalanyl-para-aminobenzoate (cFP-A-A-F-pAB) to the attenua...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(92)90053-6
更新日期：1992-09-01 00:00:00
abstract：:Three separate sets of receptors sensitive to VIP, GIP and pancreatic/entero-glucagons, have been characterized in HGT-1 cells. The order of relative potencies of VIP receptor agonists was VIP greater than rh GRF-43, rh GRF-29 greater than PHI greater than hp GRF-40, secretin. G-37 was about 4 times less potent than G...
journal_title：Peptides
pub_type： 杂志文章,评审
doi：10.1016/0196-9781(86)90174-9
更新日期：1986-01-01 00:00:00
abstract：:We report herein the isolation and characterization of a novel glycine-rich antimicrobial peptide purified from the larvae of Drosophila virilis. A range of chromatographic methods was used for isolation and its antibacterial activity against Bacillus subtilis was employed to screen for the most active fractions. The ...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2009.09.028
更新日期：2010-01-01 00:00:00
abstract：:Substance P (SP) has been implicated in the pathophysiology of ulcerative colitis (UC) and it has been suggested that blocking of its effect would be advantageous in this disease. Eosinophils have also been implicated in the pathophysiology of UC. In the present study, specimens from the sigmoid colon of UC patients w...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2004.12.018
更新日期：2005-05-01 00:00:00
abstract：:Oxytocin receptors have recently been demonstrated in human osteoblast-like (hOB) cells. In this study, oxytocin 100-1000 pmol/l increased cell proliferation of primary cultures of hOB cells, measured by [3H]thymidine incorporation, (P<0.01). In human osteosarcoma cell-line (SaOS-2), oxytocin 100 pmol/l increased cell...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/s0196-9781(02)00041-4
更新日期：2002-06-01 00:00:00
abstract：:Sympathetic neurotransmitter neuropeptide Y (NPY) is associated with vascular remodelling, neointimal hyperplasia and atherosclerosis in experimental animal models and clinical studies. In order to study the role of sympathetic nerve-produced NPY in vascular diseases, transgenic mouse model overexpressing NPY in centr...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2008.12.009
更新日期：2009-04-01 00:00:00
abstract：:As a novel vasoactive peptide, plasma coupling factor 6 (CF6) was shown to be elevated in patients with diabetes mellitus, yet the mechanism involved is unknown. We studied CF6 protein release and its potential mechanism in human umbilical vein endothelial cells (HUVECs) incubated with high glucose levels. High glucos...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2006.11.006
更新日期：2007-03-01 00:00:00
abstract：:I.c.v. injection for 9 days of either naltexone (NTX) (5, 10, 20, 40 micrograms/rat) or a selective mu peptide (CTOP) (0.125, 0.25, 0.5, 1, 3, 6 micrograms/rat) or delta (naltrindole) (NLT) (5, 10, 20 micrograms/rat) subtype opioid receptor antagonist affected sensitization to cocaine (COC) (50 mg/kg, i.p.) administer...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/s0196-9781(97)00182-4
更新日期：1997-01-01 00:00:00
abstract：:In vitro pepsin treatment of plasma proteins generates biologically active peptides such as enkephalin-related peptides. These peptides were characterized using chromatographic techniques along with a radioimmunoassay procedure involving the use of Leu-enkephalin and Met-enkephalin antisera. Serum albumin is the only ...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(94)90142-2
更新日期：1994-01-01 00:00:00
abstract：:The antinociceptive effect of i.t.-administered Tyr-d-Arg-Phe-β-Ala (TAPA), an N-terminal tetrapeptide analog of dermorphin, was characterized in ddY mice. In the mouse tail-flick test, TAPA administered i.t. produced a potent antinociception. The antinociception induced by TAPA was significantly attenuated by i.t. pr...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2013.10.003
更新日期：2013-12-01 00:00:00
abstract：:In the present study, the C-terminus of endomorphin (Tyr(1)-Pro(2)-Trp/Phe(3)-Phe(4)-NH(2), EMs) analogs [Xaa(4)-R]EMs, modified by substitution of a non-aromatic residue for Phe(4) and ending up with -NH-benzyl, were designed to generate an atypical conformationally constrained peptide set. We investigated the effect...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2007.01.002
更新日期：2007-04-01 00:00:00
abstract：:Vasoactive intestinal peptide (VIP) is a neuropeptide present in high concentrations in the hippocampus. The studies reported here demonstrate that VIP administered into the third ventricle of the brain caused amnesia in mice trained on a left-right footshock avoidance task in a T-maze. VIP resulted in amnesia when ad...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(90)90012-t
更新日期：1990-09-01 00:00:00
abstract：:Antimicrobial peptides (AMPs) are believed to be a promising class of antimicrobial agents against bacteria and fungi. To promote the clinical use of AMPs, their antimicrobial activity and susceptibility to protease degradation should be further improved. The antimicrobial peptide Jelleine-I was originally isolated fr...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2018.11.006
更新日期：2019-02-01 00:00:00
abstract：:We evaluated behavior and cognitive performance in a line of transgenic mice that overexpress the rat gene for vasopressin. Open field testing revealed greatest habituation in homozygous mice. Passive avoidance performance indicated equal learning and memory ability of transgenic compared to normal mice. Drinking beha...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(95)02047-0
更新日期：1995-01-01 00:00:00
abstract：:Tissue inhibitor of metalloproteinases-2 (TIMP-2) inhibits angiogenesis by several mechanisms involving either MMP inhibition or direct endothelial cell binding. The primary aim of this study was to identify the TIMP-2 region involved in binding to the previously identified receptor integrin α3β1, and to determine whe...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2011.08.010
更新日期：2011-09-01 00:00:00
abstract：:The pentapeptide pGlu-Asn-Cyt-Pro-Arg [AVP(4-8), termed ZNC(C)PR in this article] has been found as a metabolite of arginine-vasopressin (AVP) in rat brain and has been shown to have potent memory-enhancing activity and to yield a series of biochemical events in brain tissues. [35S]ZNC(C)PR was chemically synthesized ...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(94)90153-8
更新日期：1994-01-01 00:00:00
abstract：:The distribution of corazonin in the central nervous system of the heteropteran insect Triatoma infestans was studied by immunohistochemistry. The presence of corazonin isoforms was investigated using MALDI-TOF mass spectrometry in samples containing the brain, the subesophageal ganglion, the corpora cardiaca-corpus a...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2010.10.020
更新日期：2011-03-01 00:00:00
abstract：:Ablation of the frontal neocortex markedly enhanced the antinociceptive and cataleptic actions of beta-endorphin injected into the lateral ventricle of rat brain. This enhanced response was not affected by simultaneous administration of cholecystokinin octapeptide (CCK-8). In sham-operated rats, however, CCK-8 suppres...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(85)90046-4
更新日期：1985-03-01 00:00:00
