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Characterization of binding sites of a memory-enhancing peptide AVP(4-8) in rat cortical synaptosomal membranes.

Abstract：

:The pentapeptide pGlu-Asn-Cyt-Pro-Arg [AVP(4-8), termed ZNC(C)PR in this article] has been found as a metabolite of arginine-vasopressin (AVP) in rat brain and has been shown to have potent memory-enhancing activity and to yield a series of biochemical events in brain tissues. [35S]ZNC(C)PR was chemically synthesized with high specific activity (232 Ci/mmol), and specific binding sites for ZNC(C)PR were located in synaptosomal membrane preparations of rat brain. We identified a specific binding site for ZNC(C)PR with a Kd of 3.12 nM and Bmax of 31 fmol/mg protein in anterior cortical synaptosomal membranes in the presence of 5 mM Ni2+. A comparison of synthetic analogues of ZNC(C)PR competing with [35S]ZNC(C)PR for binding to anterior cortical receptor are presented. ZDC(C)PR, a 2-aspartyl substitute of the 2-asparaginyl residue in ZNC(C)PR, had the most potent competition, but AVP did not show significant ability to compete for the receptor with ZNC(C)PR.

journal_name

Peptides

journal_title

Peptides

authors

Du YC,Wu JH,Jiang XM,Gu YJ

doi

10.1016/0196-9781(94)90153-8

subject

Has Abstract

pub_date

1994-01-01 00:00:00

pages

1273-9

issue

7

eissn

0196-9781

issn

1873-5169

pii

0196-9781(94)90153-8

journal_volume

15

pub_type

杂志文章

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