Synthesis and biological activity of Boc [Nle28, Nle31]CCK27-33, a highly potent CCK8 analogue.

abstract：:On attempts to identify toxins showing original profile of activity among K+ channels, we purified Kbot1, a scorpion toxin that blocks Kv1 and SK potassium channels. With 28 amino-acid residues, Kbot1 is the shortest toxin sequenced in Buthus occitanus scorpion. It is linked by three disulfide bridges and its primary ...

journal_title：Peptides

authors： Mahjoubi-Boubaker B,Crest M,Khalifa RB,El Ayeb M,Kharrat R

更新日期：2004-04-01 00:00:00

abstract：:As a class of peptides with 10 cysteine residues (-C-CC-C-CC-C-C-C-C-), D-superfamily conotoxins (D-conotoxins) can specifically act on nicotinic acetylcholine receptors (nAChRs). According to the conserved signal peptides of D-conotoxins, seven D-conotoxin precursor sequences with a previously undescribed Cys arrange...

journal_title：Peptides

authors： Lu J,Zhang K,Wang S,Sun T,Yu S,Dai Q,Liu Z

更新日期：2017-08-01 00:00:00

abstract：:This report reviews the hypothesis that peptides play a role in appetite modulation, stressing that the available evidence is predominantly pharmacological and thus caution needs to be taken in assigning physiological significance at this time. Two peptide systems have been postulated--a peripheral satiety system, typ...

journal_title：Peptides

authors： Morley JE,Levine AS,Gosnell BA,Mitchell JE,Krahn DD,Nizielski SE

更新日期：1985-01-01 00:00:00

abstract：:We screened nearly 1000 synthetic peptides and found that JAL-AK22 (KYEGHWYPEKPYKGSGFRCIHI), which is derived from the BoxA domain in the Tob1 protein, activates both unfolded and folded proMMP-7. Interestingly, the smaller derivative of JAL-AK22, termed JAL-TA9 (YKGSGFRMI) possessed auto-proteolytic activity and clea...

journal_title：Peptides

authors： Nakamura R,Konishi M,Taniguchi M,Hatakawa Y,Akizawa T

更新日期：2019-06-01 00:00:00

abstract：:Venoms from cone snails (genus Conus) can be seen as an untapped cocktail of biologically active compounds, being increasingly recognized as an emerging source of peptide-based therapeutics. Cone snails are considered to be specialized predators that have evolved the most sophisticated peptide chemistry and neuropharm...

journal_title：Peptides

authors： Peigneur S,Van Der Haegen A,Möller C,Waelkens E,Diego-García E,Marí F,Naudé R,Tytgat J

更新日期：2013-03-01 00:00:00

abstract：:Previously, calcitonin gene-related peptide (CGRP) decreased food intake when administered ICV but not when administered peripherally to rats. Amylin, which has a close structural homology to CGRP, reduced food intake administered IP at concentrations higher than those previously tested for CGRP. We examined the effec...

journal_title：Peptides

authors： Morley JE,Farr SA,Flood JF

更新日期：1996-01-01 00:00:00

abstract：:Recent studies have identified compounds with reduced efficacy relative to nociceptin/orphanin FQ at the opioid-like receptor ORL1. Utilizing stimulation of [(35)S]GTPgammaS binding as in vitro assays, it was determined that both [Phe(1)psi(CH(2)-NH)Gly(2)]N/OFQ(1-13)NH(2) and the hexapeptide Ac-RYYRIK-NH(2) act as pa...

journal_title：Peptides

authors： Burnside JL,Rodriguez L,Toll L

更新日期：2000-07-01 00:00:00

abstract：:The aim of this study was to investigate peripheral and central roles of corticotropin-releasing factor (CRF) in endocrinological and behavioral changes. Plasma adrenocorticotropin (ACTH) concentration was measured as an activity of hypothalamic-pituitary-adrenal (HPA) axis. As behavioral changes, locomotion and anxie...

journal_title：Peptides

authors： Tanaka M,Tomimatsu Y,Sakimura K,Ootani Y,Sako Y,Kojima T,Aso K,Yano T,Hirai K

更新日期：2017-09-01 00:00:00

abstract：:We have previously reported that hypoxia activates corticotrophin-releasing hormone (CRH) and the expression of its type-1 receptor (CRHR1) and induces disorders of the brain-endocrine-immune network. p53 is activated by hypoxia and involved in tumorigenesis and apoptosis. Whether CRHR1 regulates p53 transactivation t...

journal_title：Peptides

authors： Zhao Y,Wang MY,Hao K,Chen XQ,Du JZ

更新日期：2013-06-01 00:00:00

abstract：:Ethanol (ETOH) has been shown to have pronounced effects on reproductive endocrinology in humans as well as laboratory animals. We have studied the effects of ETOH on the hypothalamic-pituitary-luteinizing hormone (LH) axis, using the male rat as an animal model. In order to better understand the method by which ETOH ...

journal_title：Peptides

authors： Dees WL,Kozlowski GP

更新日期：1984-01-01 00:00:00

abstract：:An outbreak caused by 2019 novel coronavirus (2019-nCoV) was first identified in Wuhan City, Hubei Province, China. The new virus was later named SARS-CoV-2. The virus has affected tens of thousands of patients in the world. The infection of SARS-CoV-2 causes severe pneumonia and even death. It is urgently needed to f...

journal_title：Peptides

authors： Ling R,Dai Y,Huang B,Huang W,Yu J,Lu X,Jiang Y

更新日期：2020-08-01 00:00:00

abstract：:We examined the effects of tumor necrosis factor (TNF)-alpha on the expression and functionality of adrenomedullin (AM) receptors in cultured human coronary artery smooth muscle cells. Analysis of real-time quantitative polymerase chain reactions showed that these cells abundantly express two AM receptors comprised of...

journal_title：Peptides

authors： Nagoshi Y,Kuwasako K,Cao YN,Imamura T,Kitamura K,Eto T

更新日期：2004-07-01 00:00:00

abstract：:Obesity is a chronic inflammatory disease significantly risen worldwide, especially among children. Adipokines, secreted from adipose tissue, are hormones involved in various cellular processes such as energy metabolism and inflammation. Among the others, adiponectin is gaining increasing interest for its insulin-sent...

journal_title：Peptides

authors： Nigro E,Piombino P,Scudiero O,Monaco ML,Schettino P,Chambery A,Daniele A

更新日期：2015-01-01 00:00:00

abstract：:A lectin was isolated from extracts of fruiting bodies of the mushroom Xerocomus spadiceus using a procedure that involved ion exchange chromatography on DEAE-cellulose, affinity chromatography on Affi-gel blue gel, ion exchange chromatography on CM-cellulose, and gel filtration by fast protein liquid chromatography o...

journal_title：Peptides

authors： Liu Q,Wang H,Ng TB

更新日期：2004-01-01 00:00:00

abstract：:Age-related changes in NPY-driven angiogenesis were investigated using Matrigel and aortic sprouting assays in young (2 months.) and aged (18 months.) mice. In both assays, NPY-induced vessel growth decreased significantly with age. In parallel, aged mice showed reduced expression (RT-PCR) of Y2 receptors and the NPY ...

journal_title：Peptides

authors： Kitlinska J,Lee EW,Movafagh S,Pons J,Zukowska Z

更新日期：2002-01-01 00:00:00

abstract：:Hypothalamic orexin neurons project to many brain areas, including hindbrain structures such as the nucleus of the solitary tract (NTS) and area postrema (AP), where orexin 1 receptors (OX1Rs) are expressed. Hindbrain administration of orexin-A increases feeding and meal size, and blockade of hindbrain OX1Rs with the ...

journal_title：Peptides

authors： Williams DL,Coiduras II,Parise EM,Maske CB

更新日期：2020-11-01 00:00:00

abstract：:The effect of melanin-concentrating hormone (MCH) on the release of alpha-melanocyte stimulating hormone (alpha-MSH) from the tilapia pituitary gland was studied in vitro. In a superfusion set up, 10 nM to 1 microM synthetic salmon MCH caused a concentration-dependent inhibition of alpha-MSH release from tilapia neuro...

journal_title：Peptides

authors： Gröneveld D,Balm PH,Wendelaar Bonga SE

更新日期：1995-01-01 00:00:00

abstract：:Galanin has been shown to be present in substantial quantities in the human and rat genitourinary tract by radioimmunoassay and immunocytochemistry. The highest concentrations measured by radioimmunoassay were found in the human vas deferens, corpus cavernosum and spongiosum and in the vagina and cervix. In man gel ch...

journal_title：Peptides

authors： Bauer FE,Christofides ND,Hacker GW,Blank MA,Polak JM,Bloom SR

更新日期：1986-01-01 00:00:00

abstract：:To identify a minimal peptide ligand that participates in recognition of heparin, we synthesized peptides extending a 29-kDa fragment in the C-terminal heparin binding domain of fibronectin. We obtained evidence that two peptides (designated D5 and D1) exhibit inhibitory activity on binding of the 29-kDa fragment to h...

journal_title：Peptides

authors： Mohri H,Katoh K,Motomura S,Okubo T

更新日期：1996-01-01 00:00:00

abstract：:Animal behavioral and neurochemical studies implicate dopaminergic systems in the neurological sequelae induced by estrogen. In the present study, we demonstrated for the first time that MIF-1, a neuropeptide unrelated to classical dopamine agonists, when given prior to, concurrently with, and after 17 beta-estradiol,...

journal_title：Peptides

authors： Rajakumar G,Chiu P,Chiu S,Johnson RL,Mishra RK

更新日期：1987-11-01 00:00:00

abstract：:A bradykinin (BK)-related peptide was isolated from heat-denaturated plasma from an elasmobranch fish, the little skate, Leucoraja erinacea after incubation with porcine pancreatic kallikrein. The primary structure of the peptide (H-Gly-Ile-Thr-Ser-Trp-Leu-Pro-Phe-OH; skate BK) shows limited structural similarity to t...

journal_title：Peptides

authors： Anderson WG,Leprince J,Conlon JM

更新日期：2008-08-01 00:00:00

abstract：:Recently, a new serine protease inhibitor family has been described in arthropods. Eight members were purified from locusts and 13 peptides have been identified by cDNA cloning. The peptides share a conserved cysteine array (Cys-Xaa(9-12)-Cys-Asn-Xaa-Cys-Xaa-Cys-Xaa(2-3)-Gly-Xaa(3-6)-Cys-Thr-Xaa(3)-Cys) with nine inhi...

journal_title：Peptides

authors： Simonet G,Claeys I,Van Soest S,Breugelmans B,Franssens V,De Loof A,Vanden Broeck J

更新日期：2004-06-01 00:00:00

abstract：:This study was designed to investigate the effects of synthetic mouse pancreatic polypeptide (mPP) on feeding and anxiety in mice. The intracerebroventricular (i.c.v.) injection of mPP (0.003-3 nmol) dose-dependently increased food intake. A significant increase was observed 20 min after i.c.v. injection and continued...

journal_title：Peptides

authors： Asakawa A,Inui A,Ueno N,Fujimiya M,Fujino MA,Kasuga M

更新日期：1999-12-01 00:00:00

abstract：:Endothelin (ET)-1 is an important peptide in cancer progression stimulating cellular proliferation, tumor angiogenesis and metastasis. ET-1 binds with high affinity to the ETA receptor (R) and ETBR on cancer cells. High levels of tumor ET-1 and ETAR are associated with poor survival of lung cancer patients. Here the e...

journal_title：Peptides

authors： Moody TW,Ramos-Alvarez I,Moreno P,Mantey SA,Ridnour L,Wink D,Jensen RT

更新日期：2017-04-01 00:00:00

abstract：:The effects of Pro-Leu-Gly-NH2 (melanotropin release inhibiting factor, MIF) and its analog, cyclo (Leu-Gly) on the mouse and rat striatal cholinergic muscarinic receptors labeled with 3H-quinuclidinyl benzilate (QNB) were investigated. 3H-QNB bound to the rat striatal muscarinic receptors at a single high affinity si...

journal_title：Peptides

authors： Das S,Matwyshyn GA,Bhargava HN

更新日期：1986-01-01 00:00:00

abstract：:Dipeptidyl peptidase-4 (DPP-4) inhibitor and exercise have proven to be effective treatments for diabetes. However, the effects of these interventions in compensatory hyperinsulinemia prediabetic period are unknown. The purpose of this study was to determine if these interventions have protective effects on β-cell fun...

journal_title：Peptides

authors： Li Y,Xiao J,Tian H,Pei Y,Lu Y,Han X,Liu Y,Zhong W,Sun B,Fang F,Shu H

更新日期：2013-11-01 00:00:00

abstract：:Lipocalin-2 (LCN-2), a peptide with diverse expression pattern, has been identified as a biomarker of various diseases as well as a factor contributing to inflammatory responses associated with excess adiposity and ensuing metabolic disorders. Although the inter-relationship between LCN-2 and excess adiposity is incre...

journal_title：Peptides

authors： Singh RG,Nguyen NN,Cervantes A,Kim JU,Stuart CE,Petrov MS

更新日期：2019-09-01 00:00:00

abstract：:Using autoradiographic method and 125I-Tyro rat CGRP as a ligand, receptor binding sites were demonstrated in the rat central nervous system. Saturation studies and Scatchard analysis of CGRP-binding to slide mounted tissue sections containing primarily cerebellum showed a single class of receptors with a dissociation...

journal_title：Peptides

authors： Skofitsch G,Jacobowitz DM

更新日期：1985-09-01 00:00:00

abstract：:Androgenic gland hormone (AGH) is known to be responsible for sex differentiation in crustaceans. The amino acid sequence of AGH-active fraction purified from androgenic glands of the terrestrial isopod Armadillidium vulgare was determined by immunoprecipitation employing three types of antibodies raised against diffe...

journal_title：Peptides

authors： Okuno A,Hasegawa Y,Ohira T,Nagasawa H

更新日期：2001-02-01 00:00:00

abstract：:A novel protease inhibitor, designated mungoin, with both antifungal and antibacterial activities, and exhibiting a molecular mass of 10kDa in SDS-polyacrylamide gel electrophoresis, was isolated from mung bean (Phaseolus mungo) seeds. The isolation procedure involved a combination of extraction, ammonium sulfate prec...

journal_title：Peptides

authors： Wang S,Lin J,Ye M,Ng TB,Rao P,Ye X

更新日期：2006-12-01 00:00:00