Abstract：
:Inferences regarding biosynthesis of LHRH in rats are made from immunocytochemical studies using LHRH antisera with varied and specific binding requirements. Immunoreactive perikarya were observed with antisera that could bind putative large molecular weight precursors of LHRH. No cells were detected with an antiserum that requires free decapeptide terminals and could not bind extended precursors. No such differential immunoreactivity was apparent in neuronal processes and neurovascular terminals. Features of intracellular processing of LHRH which can be inferred from these immunocytochemical data are: (1) the decapeptide is initially synthesized within neuronal cell bodies as a larger molecular weight peptide, extended at both the N- and C-terminals; (2) processing occurs as the newly synthesized material is transported along neuronal processes; and (3) intermediate molecular forms are converted to the active decapeptide primarily in distal portions of neuronal fibers, including the neurovascular terminal. Immunocytochemical observations in other mammalian species (humans, monkeys, ferrets and bats) allow us to further suggest that the dynamics of maturation of this hormone may differ among mammals.
journal_name
Peptidesjournal_title
Peptidesauthors
King JC,Anthony ELdoi
10.1016/0196-9781(83)90096-7subject
Has Abstractpub_date
1983-11-01 00:00:00pages
963-70issue
6eissn
0196-9781issn
1873-5169pii
0196-9781(83)90096-7journal_volume
4pub_type
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