Abstract:
:Hymenistatin I (HS-I), a cyclic octapeptide [c-(-Pro-Pro-Tyr-Val-Pro-Leu-Ile-Ile-)], was synthesized by the solid-phase peptide synthesis method and examined for its immunosuppressive activity in the humoral and cellular immune responses. The peptide activity was tested on cell lines producing various cytokines. The results are compared with the activity of the well-known immunosuppressive agent cyclosporin A (CsA). It was found that hymenistatin I exerts immunosuppressive effect (both in the humoral and cellular immune responses) comparable with that of CsA. Comparison of the influence of HS-I and CsA on cytokines production suggests that the mechanisms of the interaction with the immunological system are substantially different for the two compounds tested.
journal_name
Peptidesjournal_title
Peptidesauthors
Cebrat M,Wieczorek Z,Siemion IZdoi
10.1016/0196-9781(95)02123-xsubject
Has Abstractpub_date
1996-01-01 00:00:00pages
191-6issue
2eissn
0196-9781issn
1873-5169pii
0196-9781(95)02123-Xjournal_volume
17pub_type
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